Uses of Midorhum

Midorhum is prepared in the form of tablets with 3 main ingredients, Acetaminophen, Dextromethorphan, Loratadine used to treat symptoms of flu.
Acetaminophen:
Acetaminophen (Paracetamol or N - acetyl - p - aminophenol) is an alternative pain reliever for Aspirin, Paracetamol has analgesic and antipyretic effects equivalent to Aspirin when used in equal doses. However, it does not have anti-inflammatory effects like aspirin. Acetaminophen is an active metabolite of phenacetin that has antipyretic effects due to inhibition of Prostaglandin biosynthesis, so it is used to reduce fever and relieve pain in cases of mild to moderate pain. Paracetamol only affects the cyclooxygenase/prostaglandin of the central nervous system, so at therapeutic doses, the drug has little effect on the respiratory and cardiovascular system, does not change the acid-base balance, does not cause irritation or damage to the mucosa. stomach as when taking salicylates. Dextromethorphan
Dextromethorphan is a cough suppressant with the best treatment effect in case of dry cough, chronic cough without phlegm due to its inhibitory effect on the cough center in the medulla oblongata. However, because the drug does not have the ability to loosen phlegm, it is used in combination with many different drugs in the symptomatic treatment of the upper respiratory tract. Dextromethorphan is used in cases of cough relief due to mild stimuli such as colds, flu, inhaled stimulants. Loratadine
is a tricyclic antihistamine that acts on peripheral H1 receptors and has no central nervous system effect. Loratadine has the ability to relieve symptoms of allergic rhinitis, pruritus, and urticaria by blocking the release of histamine by mast cells and basophils. Loratadine is an antihistamine of the H2 generation, so it does not cause drowsiness when used.

Midorhum has antipyretic, analgesic, cough suppressant, allergy relief, so it is used in the treatment of flu, colds with cough, fever, headache, body aches, stuffy nose, watery Rhinitis, Rhinitis, Sinusitis, Allergic Rhinitis.

How to use:
Midorhum is prepared in the form of long film-coated tablets that should be taken orally. Users can use the drug with filtered water, carbonated water, fruit juice. There are no studies on the use of Midorhum with alcohol, however, due to the possibility of affecting liver and kidney function of the drug, it is recommended that patients use the drug with alcoholic substances such as alcohol. , beer.
Dosage:
For healthy people: take a dose of 1 tablet / time x 2 times / day Children from 12 years old take a dose of 1 tablet / day equivalent to adults. Children under 12 years old use dose 1⁄2 tablets / day x 2 times / day. In case of patients with liver failure, kidney failure when using Midorhum is recommended to take 1 tablet / day, taken every other day. Note: Take the medicine only for up to 7 days, if your condition does not improve tell your doctor. The drug is not suitable for pregnant and lactating women.

Side effects of Midorhum include side effects of Acetaminophen, Dextromethorphan, Loratadine such as fatigue, constipation, dizziness, insomnia, urinary retention, gastritis, pancreatitis, hematologic effects.

Acetaminophen:
Metoclopramide, Domperidone have the ability to increase the absorption rate of Acetaminophen. In contrast, Colestyramine has the effect of reducing the absorption of Acetaminophen. Prolonged use of Acetaminophen may increase the anticoagulant effect of coumarin and indandion When concomitant use of Acetaminophen and Phenothiazines should be aware of the possibility of severe hypothermia. Long-term alcohol use increases Acetaminophen's potential for hepatotoxicity. Simultaneous use of Acetaminophen with convulsive drugs, anti-tuberculosis drugs may cause hepatotoxicity due to increased toxicity of Acetaminophen on the liver. The plasma half-life of Acetaminophen may be prolonged by Probenecid. Dextromethorphan:
Cytochrome P450 inhibitors such as Quinidin, Thioridazine, .. reduce the metabolism of Dextromethorphan in the liver and increase the concentration of this substance in the serum because the main mechanism of metabolism of Dextromethorphan is thanks to the Cytochrome P450 isoenzyme CYP2D6. Concomitant administration of Dextromethorphan in combination with CNS depressants may increase the CNS depressant effect of the drug. Dextromethorphan when administered with Valdecoxib may increase the serum concentration of Dextromethorphan. Loratadine:
Concomitant administration of Loratadine with cytochrome P450 inhibitors or cytochrome P450-metabolized drugs may produce a change in loratadine plasma concentrations since Loratadine is also metabolised via the cytochrome P450 isoenzymes CYP3A4 and CYP2D6. Co-administration of Loratadine with Ketoconazole may lead to an increase in plasma concentrations of Loratadine up to 3-fold without clinical manifestations due to Loratadine's wide therapeutic index. Concomitant use of Loratadine with Erythromycin also increases the plasma concentration of Loratadine. Above is some information about Midorhum medicine, if you have any questions, please consult a qualified doctor or pharmacist before using the product. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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