Uses of Nibean

Nibean is an antibiotic used in the treatment of fungal diseases. The drug is prepared and packaged in the form of hard capsules. The following article will share about the effects, indications, dosage and notes when using Nibean.

Nibean drug is a drug made in the form of hard capsules, used in the treatment of fungal diseases on the skin, internal organs, vaginal yeast.
Nibean medicine has the main ingredient Itraconazole in the form of microparticles with a content of 100mg in each tablet.

2.1 Main use Nibean drug inhibits the growth and proliferation of fungal cells. Therefore, Nibean drug is used in the treatment of common fungal diseases such as nail fungus, toenail fungus, vaginal yeast, visceral fungus,...
2.2 Mechanism of action Nibean Nibean's main ingredients are: Itraconazole, which is a synthetic triazol, has a better antifungal activity than ketoconazole on some fungi. The antifungal spectrum of Nibean is also quite diverse with activity against Coccidioides, Cryptococcus, Candida, Histoplasma, Blastomyces and Sporotrichosis spp.
Nibean has an effect against Cytochrome p450 in fungi, thereby inhibiting egrosterol biosynthesis, making fungal cells unable to bind membranes. Disruption of membrane binding in fungal cells makes them unable to grow, multiply and continue to parasitize to cause disease.

Nibean is indicated in the treatment of fungal diseases as follows
People with candidiasis in the mouth - throat. People with tinea versicolor Have fungal skin diseases such as tinea pedis, inguinal skin, dark skin, interstitial skin. Fungi in fingernails and toenails. Visceral fungal infections caused by Aspergillus and Candida strains, Cryptococcus, Histoplasma, Sporothrix, Paracoccidioides, Blastomyces . Prophylactic treatment in AIDS patients to prevent recurrence of latent fungal infections. Prophylaxis of fungal infections during prolonged neutropenia in patients with inadequate response to conventional drug therapy.

In some cases of disease and drug hypersensitivity, Nibean is contraindicated in patients
Patients with hypersensitivity and history of allergy to Itraconazole or other azoles Patients who are taking medications with oral terfenadine, astemisol, triazolam , oral midazolam and cisapride Nibean should not be used to treat nail fungus in women who are pregnant or planning to become pregnant.

Conventionally, each Nibean tablet has a content of Itraconazole 100mg, a concentration of 22%, the dosage is specifically indicated as follows
In case of vulvovaginal candidiasis: 2 tablets / time, 2 times a day and used only in 1 day; or 2 tablets / time / day and take Nibean for 3 days. Ringworm: 2 tablets/time/day for 7 days. Ringworm: 2 tablets / time / day, take medicine for 7 days or 1 Nibean tablet / time / day for 15 days. Highly keratinized areas such as fungal infections on the soles of the feet, palms: 2 tablets / time, 2 times a day, maintenance dose for 7 days or 1 tablet / time / day for 30 days. Oral candidiasis: 1 tablet/time/day for 15 days. In patients with AIDS, undergoing organ transplantation or neutropenia: 2 tablets/time/day for 15 days. Toenail fungus: Take 2 tablets in the morning - 2 in the afternoon, a course of 7 days, maintain 2-3 times. Treatments must be spaced 3 weeks apart without drugs. Or use continuously 2 tablets / time / day for 3 months. Dosage of Nibean in the treatment of visceral fungal infections:
Aspergillus infections: 2 tablets/time/day, used for 2-5 months, if the disease is widespread, the dose can be increased to 2 tablets/time, twice daily, used for 2 days. -5 months. Candida infection: 1-2 tablets / time / day, use the drug for 3 weeks to 7 months. Epidural Cryptococcus infections: 2 tablets/time/day, taking the drug for 2 months to 1 year. Meningitis caused by Cryptococcus: 2 tablets / time, 2 times a day. Maintenance treatment: 2 tablets/time/day. Histoplasma infection: 2 tablets / time / day or the dose can be doubled, the average duration of use is 8 months depending on the severity of the disease. Fungal infections Sporothrix schenckii: 1 tablet / time / day, use the drug for 3 months. Fungal infection Paracoccidioides brasiliensis: 1 tablet / time / day, use the drug for 6 months. Chromomycosis (Cladosporium, Fonsecaea): 1-2 tablets 1 time / day, use the drug for 6 months. Blastomyces dermatitidis infection: 1 tablet / time / day or 2 tablets x 2 times / day, use the drug for 6 months.

The most frequently reported side effects of Nibean are nausea, gastrointestinal disturbances, headache and dyspepsia. Rare side effects are pruritus, urticaria, angioedema, menstrual disturbances in women, elevated liver enzymes, Steve Johnson syndrome.

Nibean is often used in the treatment of long-term fungal infections, so patients need to ensure liver function by regular testing. If the liver is toxic, it is necessary to stop the drug or adjust the drug from the doctor.
Nibean is one of the most effective and broad spectrum antifungal agents available today. The drug is in the form of tablets, taken orally. However, this is a drug for long-term treatment and requires a doctor's prescription, so patients must be very careful before taking the drug.