Uses of Periwel 4

Periwel 4 contains the active ingredient Perindopril 4mg as the main active ingredient. The drug is used in the treatment of cardiovascular diseases such as high blood pressure or heart failure.

Periwel 4 contains the active ingredient Perindopril erbumin 4mg as the main active ingredient. The drug is used in the treatment of cardiovascular diseases, especially hypertension.

Periwel 4 belongs to the group of angiotensin-converting enzyme inhibitors. The drug is administered orally and is rapidly absorbed with absorption rates up to 65 to 70% of the administered dose.
When entering the body, perindopril hydrolyzes to perindoprilate. This is a specific inhibitor of the enzyme angiotensine. Drug concentrations peak in plasma after 3 to 4 hours.
Mean steady state is reached after about 4 days when perindopril is used as a single daily dose for several days. The half-life of the drug is approximately 24 hours. In patients with renal impairment or elderly patients with creatinine clearance less than 60 ml/min, plasma concentrations of perindoprilate were significantly increased. ACE inhibitors can cross the placental barrier.

Perindopril belongs to a class of drugs that inhibit the conversion of angiotensin I to angiotensin II. This type of ACE has vasoconstrictor effects and stimulates aldosterone secretion in the adrenal cortex. This leads to a decrease in aldosterone secretion, a decrease in preferential effects on the muscles and kidneys, which helps to reduce the effect of salt and water retention or increase the reflex heart rate in long-term treatment.
In patients with low or normal renin levels, the drug exhibits a hypotensive effect. Perindopril's action is mediated by the active metabolite perindoprilate and the other metabolites are inactive.
Some of the antihypertensive effects of the drug include:
The drug is effective in stages of hypertension such as mild, moderate and severe. The drug has been shown to reduce systolic and diastolic blood pressure in both the supine and standing positions. Time to reach the maximum effect after 4 to 6 hours of use with only a single dose and maintain at least 24 hours. After discontinuation of use, no increase in blood pressure occurred. The drug also acts as a vasodilator, helping to restore the elasticity of the great arteries and reduce left ventricular hypertrophy. In some necessary cases, the doctor may appoint a combination with Thiazide diuretics to have a synergistic effect. On the other hand, the combination of ACE inhibitors and thiazide diuretics reduces the risk of hypokalemia compared with diuretics alone. Perindopril reduces the workload on the heart when used in patients with heart failure by:
Through the process of regulating prostaglandine metabolism helps to dilate veins. Thereby reducing the burden. Reduces afterload through a mechanism of action that reduces total peripheral resistance

For each treatment goal, there will be different dosages such as:
Hypertension: Take a single dose of 4mg orally in the morning. It can then be increased to 8 mg after 1 month. Congestive heart failure: Take 2 mg/day in the morning, then 15 days can increase to 4 mg/day. Elderly patients take 2 mg/day, after 1 month can increase to 4 mg/day.

Patients with a history of hypersensitivity reactions to perindopril. Angioedema (Quincke's edema) has been observed following the use of an ACE inhibitor. Women who are pregnant or breastfeeding. Relative contraindications for the following cases:
Patients with renal artery stenosis when only one working kidney remains or bilateral renal artery stenosis. The patient has hyperkalemia. The patient is taking potassium-sparing diuretics, potassium salts, and lithium.

Clinically, patients may present with some of the following symptoms:
Headache, feeling of dizziness, weakness, cramps, mood disturbances and/or sleep disturbances. Postural hypotension. Skin rash. Stomach pain, nausea, loss of appetite, abdominal pain, change in taste. A dry cough is a common side effect reported with ACE inhibitors. This symptom persists and resolves upon discontinuation of use. Increases in plasma urea and creatinine concentrations are moderate, which is reversible upon discontinuation of the drug. This side effect is common in patients with renal artery stenosis, renal failure, and hypertension who are treated with diuretics. In patients with glomerular disease, ACE inhibitors may cause proteinuria. Transient hyperkalemia Special conditions such as kidney transplantation, dialysis may cause anemia when taking ACE inhibitors. In summary, the drug Periwel 4 has the effect of increasing blood pressure and heart failure. Patients should carefully read the instructions for use, consult a doctor before use. Absolutely do not buy medicine to treat on your own because there may be unwanted side effects.