Uses of the drug Axcel urea

Axcel urea cream is used in the treatment of ichthyosis, cases of dry, cracked, scaly and itchy skin. On the market today there is a lot of information about the drug Axcel urea, but it is still incomplete. To better understand what Axcel urea cream is, its uses and notes when using it, read the article below.

Axcel urea cream has the main ingredient is urea, belongs to the group of drugs to treat warts and calluses, is prepared in the form of a tube of topical cream with a content of 5 grams. Drugs manufactured by Kotra Pharma Company (M) Sdn. Bhd – Malaysian manufacture.
Axcel urea cream is prescribed by doctors to use in the following cases:
Treatment of skin hyperkeratosis (also known as ichthyosis), cases of itchy, dry, scaly skin; Dermatitis caused by contact with irritants, detergents, soaps or highly alkaline chemicals; Keratinization disorders (calluses on hands and feet); Atopic eczema acute and chronic phase; Eczema in children ; Dry, itchy skin in winter.

The mechanism of action of urea is to break the normal hydrogen bonds of the keratin protein, through its keratinolytic and hydrating effects, to promote desquamation in the stratum corneum of the skin in cases of dry skin and horny skin. (psoriasis - psoriasis, ichthyosis, ...). Urea also acts to make certain drugs penetrate the skin more quickly (for example, the drug axcel urea can increase the rate of absorption of hydrocortisone by 2 times compared to normal). Therefore, it is common to add 1% hydrocortisone ingredient in medicinal preparations to act as anti-inflammatory agents.
According to the osmotic mechanism, Urea (carbamide) was once used in the form of an injectable solution to make a diuretic, but because the drug causes many unwanted side effects, so far, it has not been used anymore, but has been replaced. with mannitol.
Urea 40 to 50% solution is also used by injection into the amniotic cavity to terminate pregnancy in the second trimester of pregnancy, this effect is due to the release of prostaglandins from decidual cells. destroyed by a hypertonic urea solution. Hypertonic urea with intravenous oxytocin is sufficient to induce uterine contractions to expel the fetus and to abort the placenta; however, approximately 30-40% of patients may have an incomplete abortion with this method.
Urea labeled with carbon-13 (13C) is used for the in vivo diagnosis of Helicobacter pylori infection based on the amount of 13C-carbon dioxide measured in the breath before and after a single dose of 13C-urea, because H pylori produces urease that hydrolyzes urea to ammonia and carbon dioxide, thus producing an excess of 13C-carbon dioxide compared to before drinking 13C-urea. This trial was not performed within 4 weeks of antibiotic therapy and within 2 weeks of treatment with gastric inhibitors.
2.2. Pharmacokinetics of the drug Axcel urea Absorption: Urea can be rapidly absorbed from the gastrointestinal tract, but is irritating to the stomach and intestines. The drug is hydrolyzed to carbon dioxide and ammonia and then re-synthesized to urea; Distribution: Urea is distributed into intracellular and extracellular fluids, including bile, cerebrospinal fluid, blood, and lymph. Urea can cross the placenta and get into the eyes; Elimination: Urea is eliminated unchanged in the urine.

The patient is allergic to any of the ingredients or excipients of the drug Axcel urea cream; Avoid using when skin is swollen, open wound or oozing fluid; There is no information on the effects of Urea when used topically on pregnancy and lactation. Use during pregnancy and lactation only when the potential benefits outweigh the possible risks.

Urea topical cream is well tolerated, but burning and stinging can sometimes be experienced on the skin, especially in people with inherently sensitive skin.
Axcel Urea® can cause some side effects including:
Constipation ; Drowsiness; Dizzy; Nausea; Bronchospasm; Vomiting; Skin allergies; Respiratory depression. This is not a complete list of side effects and others may occur. If you have any questions about side effects, consult your doctor or pharmacist.
* Treatment: in cases of adverse reactions, if the above drugs should be used, the symptoms will gradually disappear. For severe cases or allergic reactions, it is necessary to immediately contact the treating doctor for timely intervention (opening the airways, using Epinephrine, breathing oxygen through a catheter, using corticosteroids, antihistamines ...)

You must carefully read the instructions for use before using Axcel urea cream = . Ask your doctor or pharmacist about anything you are not sure about regarding medication.
You must take the medicine exactly as prescribed by your doctor, do not take more or less than the prescribed dose, and do not stop taking it without your doctor's permission.
Medicines for topical use, apply the cream to the affected skin several times a day.
Overdose: When using topical Urea cream does not seem to occur because Urea is very little absorbed through the skin. However, when accidentally swallowed Urea cream can irritate the stomach lining, nausea and vomiting may occur. At that time, it is necessary to treat the symptoms immediately.
In summary, Axcel urea cream belongs to the group of drugs for warts and calluses, used in the treatment of ichthyosis, cases of dry, cracked, scaly and itchy skin. Use Axcel urea cream as prescribed by your doctor to ensure safety and promote effective treatment.