Uses of the drug Caorin

What is Caorin drug? The main ingredients of the drug Caorin include: Calcitriol 0.25mcg, Calcium Lactate 425mcg, Magnesium Oxid 40mg, Zinc Oxid 20mg and a system of excipients including: Medium chain Triglycerides, Lecithin, Palm Oil, Partially Hydrogenated Soybean Oil , White Beeswax, 95% Alcohol, Butylate Hydroxy Toluene, Butylate Hydroxy Anisol, Gelatin, Concentrated Glycerin, D - Sorbitol 70%, Ethyl Vanillin, Methylparaben, Propylparaben, Titanium Dioxide, Red No. 40, Yellow No. 5, Water pure. Calcitriol is one of the active metabolites of Vitamin D, which is normally formed in the kidney from a 25-hydroxycholecalciferol precursor. Normally, this amount when born will increase the absorption of Calcium and Phosphate, which are two substances that play an important role in the process of bone mineralization. In people with chronic renal failure, poor production of Calcitriol contributes to the abnormality of mineral metabolism.
Magnesium is a very important mineral involved in hundreds of enzymatic reactions in the human body. Magnesium is essential for calcium supplementation because it is an intermediate in the conversion of Vitamin D to its active form.
Zinc also plays an important role in the body's absorption of Calcium and improves the immune system.
Caorin drug is indicated in the treatment to reverse the disorders of calcium metabolism in patients with chronic kidney disease. hypothyroidism, Vitamin D-dependent rickets and osteoporosis.

Caorin drug is used orally as prescribed by the doctor. Dosage of Caorin drug is usually 1-2 tablets depending on the needs of the patient.
Caorin drug overdose can cause hypercalcemia and sometimes hypercalciuria. Therefore, every time the dose of Caorin is adjusted periodically at regular intervals, the doctor needs to check the patient's serum calcium level.
Overdose of zinc can lead to symptoms of Caorin overdose such as severe nausea, vomiting leading to dehydration and iron deficiency anemia secondary to zinc depleting copper.
Treatment of overdose: Stop taking Caorin, stop adding calcium, maintain a low-calcium diet, drink plenty of water or may prescribe intravenous fluids.

Caorin should not be used in patients with hypercalcemia or evidence of vitamin D toxicity; Contraindicated Caorin drug for patients with hypersensitivity to the drug (or active ingredients of the same group) or components of the drug Caorin.

Caorin drug can cause Vitamin D overdose with early or late signs and symptoms of Vitamin D toxicity accompanied by hypercalcemia, including:
Early symptoms: sick patient, headache, drowsiness , nausea or vomiting , dry mouth , constipation , muscle aches , bone pain , metallic taste in mouth , loss of appetite , pain in the abdomen , stomach pain . Late symptoms: Patients may urinate more, thirst more, anorexia, weight loss, nocturia, conjunctivitis (calcification), pancreatitis, photophobia, runny nose, itching, fever, decreased sexual ability, increased BUN levels, Albuminuria, hypercholesterolemia, AST and ALT elevation, ectopic calcification, renal calcium infection, hypertension, arrhythmia, dystrophy, sensory disturbances, dehydration , apathy, growth retardation, urinary tract infection, rarely obvious mental status.

Animal toxicity studies have not produced conclusive results, nor are there adequate human studies on the effects of exogenous Calcitriol on pregnancy and fetal development. Therefore, only use Calcitriol when the benefit outweighs the possible risk to the fetus in the womb. Calcitriol of exogenous origin is also excreted in breast milk. Therefore, nursing mothers when taking Calcitriol must monitor the serum calcium levels of the mother and baby.

Cholestyramine: This active ingredient will reduce the intestinal absorption of lipid-soluble vitamins, thereby hindering the absorption of Caorin drug through the intestine. Phenytoin/Phenobarbital: Co-administration of Caorin with Phenytoin (or with Phenobarbital) has no effect on plasma concentrations of Calcitriol, however these drugs may reduce plasma concentrations of endogenous 25(OH)D3. due to increased metabolism. Because the level of Calcitriol in the blood is reduced, patients need higher Caorin when combined with Phenytoin or Phenobarbital. Thiazides promote hypercalcemia by reducing urinary calcium excretion, when combining Thiazides with Caorin drugs will cause hypercalcemia, so caution must be exercised when combining these two drugs together; Concomitant use of Caorin with cardiac glycosides because the toxicity of cardiac glycosides will increase due to hypercalcemia, leading to arrhythmias.