Uses of the drug Datadol Extra

Datadol Extra is a combination pain reliever that provides rapid relief of mild to moderate pain symptoms. To be able to use drugs safely and effectively, you need to understand more about their uses.

The main ingredients of Datadol extra are Acetaminophen (paracetamol) 500mg and Caffeine 65mg. Prepared in the form of tablets.
Some uses of the ingredients in the drug:
Paracetamol or Acetaminophen Belongs to a group of non-steroidal anti-inflammatory drugs, whose main effect is pain relief and fever reduction. The drug acts on the hypothalamus to cause hypothermia, increased heat loss due to vasodilation, and increased peripheral blood flow. Due to the effect of inhibiting the enzyme cyclooxygenase (COX) and reducing the production of prostaglandins by the central nervous system, it has an analgesic effect. However, unlike non-steroidal anti-inflammatory drugs, Paracetamol has no effect on platelet aggregation or bleeding time, and has almost no anti-inflammatory effect.
When using Paracetamol has the effect of lowering body temperature in patients with fever but rarely lowering body temperature in normal people. When the drug is overdosed, it is not metabolized through the usual route, but metabolized by another route and produces a metabolite called N-acetyl-benzoquinonimin, which is severely toxic to hepatocytes.
Caffeine Caffeine has a stimulant effect on the central nervous system. Caffeine inhibits phosphodiesterase enzyme activity and has an antagonistic effect at the central adenosine receptor. In addition, when taking caffeine can stimulate the respiratory center. This substance is often used in combination with low doses with oral pain relievers such as aspirin, paracetamol to increase the analgesic and antipyretic effect of this drug.

Datadol is indicated for use in the following cases:
Treatment of mild to moderate pain symptoms such as: Headache, toothache, backache, muscle pain, menstrual pain, rheumatic pain, degeneration articulation. When used alone, Paracetamol does not provide pain relief or is less effective. Reduce mild to moderate fever in cases of fever caused by viruses, bacteria... Contraindications:
Datadol extra is not indicated in the following cases:
Patients are sensitive to the main ingredients including paracetamol, caffeine or any of the excipients of the drug. The patient suffered from anemia many times because he masked signs of serious side effects. Cardiovascular disease (coronary artery failure, myocardial infarction, tachycardia), lung disease, liver failure, severe renal failure Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. People with alcohol addiction. Children under 12 years old are not allowed.

3.1 How to take The medicine is in the form of tablets, it should be taken with a full glass of water. Patients can take it with or without food. The dose may be repeated after a minimum of 4-6 hours if necessary.
3.2 Dosage Dosage of the drug may vary from person to person and from case to case. Below is the reference dose:
Adults and children 12 years of age and older: Take 1 to 2 tablets and from 2 to 3 times a day. Do not take more than 8 tablets/day. Or calculate dose by weight 10-15mg Paracetamol/kg body weight. Do not use paracetamol-containing medicines for pain relief for more than 10 days in adults or not more than 5 days in children, unless the use of Datadol extra is directed by a physician. Do not use paracetamol for adults and children to self-treat high fever, fever lasting more than 3 days, fever poorly responding to paracetamol or recurrent fever, the cause should be found for effective treatment. 3.3 Overdose and missed dose Datadol extra Overdose:
Paracetamol: When overdose can cause common symptoms such as nausea, vomiting, abdominal pain, loss of appetite, increased methemoglobinemia leading to cyanosis on the skin, cyanosis of mucous membranes and nails. Children tend to make methemoglobin more easily than adults after taking an overdose of paracetamol. In case of overdose, the patient should contact the doctor for appropriate indications. Caffeine: Caffeine overdose is very rare. Possible symptoms of overdose include fever, rapid breathing, restlessness, insomnia, tachycardia, tremor, convulsions. Management: Treatment should be symptomatic and supportive. Missed dose:
If you miss a dose, you can take it when you remember or skip the missed dose and take your next dose at the next time.

If the patient uses Datadol extra at the right dose and does not abuse the drug, it usually causes less side effects. However, in rare cases, unwanted side effects may still occur:
For Paracetamol
Skin rash and allergic reactions are very rare, usually erythema or urticaria, but Sometimes the patient may be more severe and accompanied by fever due to drugs, mucosal damage. In rare cases paracetamol causes neutropenia, thrombocytopenia and may cause pancytopenia. Less commonly, it can cause nausea, vomiting, headache, insomnia, nephrotoxicity with long-term abuse. For caffeine:
Common side effects include: Insomnia, nervousness, anxiety, irritability, headache, digestive disorders. Very rare serious side effects such as anaphylaxis including rash, itching or swelling (especially of the face, tongue, and throat), dizziness, difficulty breathing, chest pain. When experiencing side effects of the drug, especially serious side effects, it is necessary to stop using and notify the doctor or immediately go to the nearest medical facility for timely treatment.

This is a drug that treats symptoms and does not replace drugs to treat the cause. So if you take medicine but do not improve, you need to see a doctor to find the cause of the disease, for effective treatment. Avoid the use of alcohol during treatment with paracetamol-containing medicines because both ingredients are harmful to the liver, increasing the risk of liver toxicity. Avoid taking the drug at the same time with foods or drinks containing caffeine because it increases the side effects of caffeine. Pregnancy and breast-feeding: Currently, there are no reports of unwanted effects in pregnant women who are breast-feeding when using paracetamol. But caffeine is able to cross the placenta and cause fetal abnormalities when used in very high doses. Therefore, you should consider when using this medicine if you are pregnant and breast-feeding. Caution when used for people with phenylketonuria - and those who have to limit the amount of phenylalanine put into the body: Because some paracetamol preparations contain aspartame, it will be converted in the stomach - intestines into phenylalanine after taking. Do not use several different drugs with similar effects and composition at the same time, because the risk of toxicity and overdose is increased.

For paracetamol:
Long-term administration of high doses of Paracetamol slightly increases the anticoagulant effect of coumarin and indandion derivatives. Attention should be paid to the risk of severe hypothermia in patients receiving concomitant phenothiazines and with an antipyretic therapy. Excessive alcohol consumption and long-term drinking can increase the risk of paracetamol's hepatotoxicity. Anticonvulsants (phenytoin, barbiturates, carbamazepine) induce hepatic microsomal enzymes, which may increase the hepatotoxicity of paracetamol. Concomitant use of isoniazid with paracetamol may also lead to an increased risk of hepatotoxicity. Probenecid may decrease the elimination of paracetamol and increase the plasma half-life of paracetamol. Anti-tuberculosis drugs also increase the toxicity of paracetamol to the liver. For caffeine:
Antibiotics ciprofloxacin, norfloxacin have the effect of increasing the storage time of caffeine in the blood, thus increasing the harmful effects of caffeine. Taking theophylline at the same time as caffeine increases the concentration of theophylline in the blood and causes side effects such as nausea, vomiting, and heart palpitations. Caffeine increases the possible risks of taking ephedra. In addition, some other interactions may occur, so carefully read the instructions to avoid using drugs that interact with each other, increasing the risk of harm to the body.
Hopefully, with the above information, you already know what the drug Datadol extra is, how it works and how to use the drug to achieve the highest efficiency, limiting the risk of harm to the body.