Uses of the drug Petasumed 2g

Petasumed 2g has the main ingredient in the group of antibiotics, used in the treatment of infections caused by susceptible bacteria such as upper and lower respiratory tract infections, abdominal infections, genital tract infections. ...

Petasumed 2g has the main ingredient is Cefoperazone (in the form of Cefoperazone sodium) 0.5g; Sulbactam (as sulbactam sodium) 0.5g, belongs to the group of drugs for parasites, anti-infectives, antivirals, antifungals. The drug is prescribed by doctors for the treatment of infectious diseases caused by sensitive bacteria such as:
Respiratory tract infections; Urinary tract infections ; Blood infections and infections of bones and joints; Treatment of meningitis and skin and soft tissue infections; Cholecystitis, peritonitis, cholangitis , other intra-abdominal infections; Pelvic infections, endometritis, gonorrhea and some other genital infections. Mechanism of action: Ingredients Efoperazone and Sulbactam are semi-synthetic antibiotics belonging to the 3rd generation Cephalosporin group, it has the effect of killing bacteria that are developing disease.

How to use: The drug is prepared in the form of a powder for injection and used to be diluted with other solutions for intramuscular or intravenous infusion.
Dosage:
Adults: In the treatment of mild and moderate infections can use a dose of 1-2g (Cefoperazone) every 12 hours. For the treatment of severe infections use higher doses of 2-4 g every 12 hours. For pediatric patients use 25-100mg/kg every 12 hours. Dose for patients with renal impairment: Apply the usual dosage, it is not necessary to reduce the dose of Cefoperazone. Dosage for people with liver disease or biliary obstruction can be used according to the usual adult dose but should not be used more than 4g/24 hours. Contraindications:
Petasumed 2g should not be used in patients with a history of allergy to penicillin, sulbactam, cefoperazone or any cephalosporin antibiotic.

Manifestations: May cause side effects on the nervous system such as seizures, increased neuromuscular excitability, convulsions (especially in people with kidney failure).
How to handle: Usually the doctor will prescribe treatment according to the symptoms that the patient experiences and in the case of an overdose caused by the patient suffering from kidney failure, hemodialysis can be used to remove remove Cefoperazone and Sulbactam from the body.

Petasumed 2g is evaluated as a drug with good tolerability and most of the side effects it causes are usually mild and moderate. Common side effects include:
Effects on the digestive system: Like other antibiotics, patients experience side effects occurring on the digestive system with manifestations such as diarrhea, nausea, vomiting. .
Effects on hematopoietic system: When patients use the drug for a long time, there may be problems such as reversible leukopenia, positive Coomb's reaction in a small number of patients, decreased hemoglobin and red blood cells, decreased transient eosinophilia, platelets and hypoprothrombinemia.
Effects on the skin: Most of the drugs in the group of antibiotics Penicillin and Cephalosporin, when used, patients experience allergic skin reactions with skin rash, urticaria.

Caution when using drugs containing Cefoperazone and Sulbactam ingredients for subjects with a history of allergy to Penicillin. Pseudomembranous colitis has been reported in patients receiving Cefoperazone in combination with other broad-spectrum antibiotics. Patients should be advised not to drink alcohol while using Cefoperazone and Sulbactam injections. Pregnancy: Although there have been no clinical studies in humans, animal studies have shown that Cefoperazone and Sulbactam are excreted in the placenta. Therefore, doctors recommend that the drug should be used by pregnant women only when absolutely necessary. Lactation: Cefoperazone and Sulbactam are absorbed into breast milk in small amounts. However, care still needs to be taken when using Petasumed 2g for nursing mothers.

Drug interaction is the interaction between Petasumed 2g drug with other drugs or between Petasumed 2g drug and other foods. It may decrease its effectiveness or increase unwanted side effects. Therefore, patients during treatment with Petasumed 2g should note some of the following possible interactions:
Drinking alcohol or using alcohol-containing products during drug use, it can cause inhibition aldehyde dehygrogenase, accumulates in the blood and side effects such as: Sweating, headache, arrhythmia. Therefore, in patients who are using Petasumed 2g, products containing alcohol should be avoided. Aminoglycoside antibiotics: Note that Sulbactam / Cefoperazone and Aminoglycosides should not be mixed together, because it will reduce the effectiveness of the drug, because between these two groups of drugs may cause physical incompatibility. In cases where it is necessary to use the combination, it is advisable to divide the infusion time of the two drugs and wash the infusion tube between the two doses. Anticoagulants, thrombolytics: Be careful when combining with anticoagulants, thrombolytics, and non-steroidal anti-inflammatory drugs because they cause bleeding side effects. Petasumed 2g should not be mixed with the following drugs: Amikacin, Ajmalin, Potassium magnesium aspartate, Meclofenoxate, Gentamicin, Ketamycin B, Doxycynlin, Diphenhydramine to avoid precipitation. When mixed with solutions of Hydroxylin dihydrochloride, Procainamide, Aminophillin, Prochlorperazine, Cytochrome C, Pentazocin, Aprotinin should not be left for more than 6 hours because it will change the properties of the drug. Effects on test results: The urine glucose reaction may be falsely positive when the drug is dissolved with Benedict's or Fehling's solution. Positive anti-globulin (Coomb) tests, especially in neonates when the mother is taking the drug at the time of delivery. A few cases resulted in elevations of ALP, AST, ALT, BUN and serum creatinine. The article provides information about what Petasumed 2g is, dosage and note when using. To use Petasumed 2g effectively, patients need to consult and use the drug exactly as directed by the doctor.