Uses of Tribetason

Packing: Box includes 1 tube x 10g.
Dosage form of the drug: Topical cream
Ingredients: Each tube of Tribetason contains the following ingredients:
Betamethasone Dipropionate 6.4mg. Gentamicin 10mg. Clotrimazole 100mg. Other excipients with sufficient quantity of 1 tube. Effects of the main ingredients:
1.1. Effects of Betamethasone Dipropionate Betamethasone is a derivative of Prednisolone containing Fluorine, which has anti-inflammatory effects but stronger than Hydrocortisone, anti-allergic effects, this active ingredient belongs to the group of long-acting corticosteroids.
Anti-inflammatory effects Similar to other types of corticosteroids, Betamethasone drug affects the synthesis of some substances that participate in the body's inflammatory reactions such as leucotriene and prostaglandin. Through, increased production of lipocortin leads to inhibited phospholipase A2 ability to function. Phospholipase A2 is an enzyme involved in the synthesis of arachidonic acid, which is necessary for the synthesis of leucotrienes and prostaglandins. Thus, Betamethasone will reduce the synthesis of leucotriene and prostaglandin, thereby reducing the symptoms of the inflammatory response.
On the other hand, the anti-inflammatory mechanism of Betamethasone can also be explained by affecting the white blood cells, reducing their migration to the site of inflammation in the body.
Anti-allergic effect Betamethasone works to reduce signs of allergies by inhibiting the enzyme that catalyzes the production of diacylglycerol and inositol triphosphate, Phospholipase C. Used to alter the permeability of mast cells and white blood cells, thereby releasing substances involved in allergic reactions. However, when Phospholipase C is inhibited, these two substances cannot be synthesized, so they cannot change the permeability to release substances involved in allergic reactions such as Histamine... from mast cells and white blood cells. At that time, the active ingredient Betamethasone will work to reduce allergy symptoms. Thus, Betamethasone drug has a combination of 3 active ingredients with anti-inflammatory, anti-allergic, antifungal and antibacterial effects.
1.2. The effect of Clotrimazole Pharmaceutical substance Clotrimazole is a broad-spectrum antifungal drug that inhibits the growth of pathogenic fungi such as Dermatophytes, Malassezia Furfur and yeasts,... Similar to other drugs in this group, Clotrimazole can act on some fungi such as: Candida, Microsporum spp, Trichophyton spp... In addition, the drug also acts on some bacteria such as: Trichomonas, Staphylococcus (staphylococcus).
Mechanism of action:
At the recommended therapeutic dose, the drug Clotrimazole acts on the formation of Ergosterol of the cell wall. However, at higher therapeutic doses, it also causes membrane damage through a mechanism other than sterol synthesis. Clotrimazole inhibits the synthesis of nuclear acid. This causes a disorder of lipid and polysaccharide metabolism, leading to damaged cell membranes. 1.3. Effect of Gentamicin This is an antibiotic with the ability to kill bacteria by inhibiting protein synthesis. Gentamicin drug belongs to the group of antibiotics Aminoside, has bactericidal effect. The spectrum of action of Gentamicin: The drug is active against both gram-negative bacteria and some gram-positive bacteria, especially good for gram-negative aerobic bacteria but not for anaerobic bacteria. Mechanism of action: Similar to other antibiotics of the Aminoside antibiotic group, Gentamicin acts on bacterial protein synthesis by binding to the 30S subunit of the ribosome. Thereby, the drug causes the ribosome structure to be deformed. At that time, the protein synthesis of bacteria is affected, foreign proteins are produced that are toxic to bacteria. At the same time, the necessary proteins are not synthesized leading to the destruction of many bacteria.

Tribetason drug is used in the following cases:
With anti-inflammatory effect, Tribetason drug is indicated in the treatment of a number of dermatological diseases related to inflammatory reactions such as: Contact dermatitis, eczema, inflammation seborrheic skin, chronic Lichen planus. With anti-inflammatory and anti-allergic effects, Tribetason is indicated in the treatment of atopic dermatitis, urticaria, and rashes. With antifungal action, Tribetason is indicated in the treatment of interstitial fungus. With antibacterial and anti-inflammatory effects, the drug can be indicated in cases of skin inflammation caused by bacterial infections. In addition, the drug Tribetason is also indicated in the treatment of some dermatological diseases such as psoriasis, vitiligo.

3.1. How to use Tribetason Clean the skin to be treated clean. Then, gently pat dry with a clean towel. Take a moderate amount of the medicine on a cotton swab or hand after washing, gently and evenly spread over the entire surface of the diseased skin and around. Use Tribetason regularly and continuously for the best effect. If after a period of treatment, the symptoms of the disease do not improve, see the doctor again. 3.2. Attention when using Tribetason: Do not use the drug on a large scale due to increased absorption of the drug into the general circulation, leading to systemic unwanted effects, especially inhibition of the hypothalamic-pituitary axis - adrenals. Avoid direct contact with eyes, mouth or other mucous membranes. 3.3. Dosage of Tribetason When using Tribetason to treat skin diseases, use the drug twice a day, apply once in the morning and once in the evening. Follow the doctor's instructions for treatment, if after a period of treatment, the lesions still have no signs of recovery, it is necessary to report back to the doctor for further treatment advice. Tribetason should not be applied in the areas around the oral mucosa, eyes or thin skin areas, skin folds to limit unwanted effects that may occur.

In case of missed dose: You need to use it again as soon as you remember. However, you should skip it if the time to remember is close to the next time you use it. The next dose of Tribetason must still be applied as scheduled.
In case of overdose: To date, no case of overdose has been recorded. However, Tribetason is likely to be absorbed into the body and increases the risk of systemic side effects if taken in excess. Therefore, if there is a suspicion of drug poisoning, take the person who has taken an overdose immediately to the nearest medical facility for timely monitoring and treatment.

Some unwanted effects when using Tribetason drug are related to allergic reactions due to allergies to some components of the drug such as: red rash, itching or urticaria. Some other undesirable effects on the skin have been reported after using the drug such as: skin atrophy, slow scar formation, dry skin, fish scales on the skin that may be related to the use of corticosteroids. If you experience the above undesirable effects, you need to actively report it to your doctor for treatment. If signs of an allergic condition appear, stop using the drug and report it to your doctor to choose an alternative medicine. Because Tribetason has a corticosteroid component, it should not be used for a long time on a large area of ​​skin because it can cause systemic effects and some unwanted effects may occur such as cataracts, myasthenia gravis. , acute adrenal insufficiency when the drug is stopped abruptly...

Interaction when using Tribetason in combination with other topical drugs such as Amphotericin or other antibiotic-containing preparations. This can lead to a decrease in the therapeutic effect of the drugs used. Therefore, it is necessary to immediately inform the treating doctor or clinical pharmacist of the drugs being used for reasonable adjustment.

7.1. Contraindications of the drug Tribetason Tribetason drug is contraindicated in people with a history of allergy and hypersensitivity to Gentamycin and general Aminoside antibiotics. Tribetason is contraindicated in people with a history of allergy and hypersensitivity to Betamethasone, Clotrimazole and other excipients contained in the drug. Tribetason is contraindicated to treat all people with skin diseases caused by viruses such as Herpes simplex, Varicella zoster virus. The drug is contraindicated for use in people who have had second-degree burns or applied to open wounds due to increased absorption and the risk of systemic effects. The drug is contraindicated in the treatment of systemic fungal infections caused by the risk of superinfection. Contraindicated to use Tribetason drug to treat eczematous dermatitis of the outer ear canal because aminoside antibiotics can be toxic to the ear. Tribetason medicine should not be applied to the private areas because it can cause the risk of superinfection and some other unwanted effects when using the drug in this area. 7.2. Use of Tribetason in pregnancy and lactation For pregnant women: Because the safety and risks of using topical corticosteroids in pregnant and lactating women have not been fully established. . However, to be safe for mother and baby, Tribetason should only be used when absolutely necessary when the benefits of the drug outweigh the risks. Therefore, do not arbitrarily use it without a doctor's prescription. For breast-feeding women: It is not known whether Tribetason can cause unwanted effects on children when used. However, to ensure safety, women who are breastfeeding should only use the drug when absolutely necessary and demonstrated that the benefits of the drug outweigh the risks. If using the medicine, do not apply the medicine to the area around the nipple to avoid the baby coming into contact with the medicine. For drivers and machine operators: Does not affect concentration, so Tribetason can be used for these subjects. The drug Tribetason 10g contains the main ingredients Betamethasone, Gentamicin and Clotrimazole. The drug has a good effect in the treatment of skin diseases such as inflammation, allergies, fungi, insect bites, foot water, ... To ensure effective treatment and avoid side effects, patients need to use it. prescription drugs or seek the advice of a specialist doctor or pharmacist.
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