Uses of Trimackit

Trimackit medicine contains two main ingredients, sulfamethoxazole and trimethoprim. In there. Sulfamethoxazole is a sulfonamide that competitively inhibits bacterial folic acid synthesis, while trimethoprim, a pyrimidine derivative, specifically inhibits bacterial dihydrofolate reductase. The combination of sulfamethoxazole and trimethoprim inhibits two successive stages of folic acid metabolism, thereby effectively inhibiting the synthesis of purine, thymine, and ultimately bacterial DNA, and finally, the killing effect. bacteria. In addition, this synergistic mechanism also helps to combat the development of drug-resistant bacteria and makes the drug effective even when the bacteria are resistant to each component of the drug.
Pharmacokinetics: After oral administration of Trimackit, both sulfamethoxazole and trimethoprim are rapidly absorbed and have high bioavailability. The half-life of sulfamethoxazole is 11 hours and that of trimethoprim is 9-10 hours, so 12 hours apart is appropriate.
Trimackit is usually indicated in the following cases:
Uncomplicated, chronic or recurrent lower urinary tract infections. Infectious prostatitis. Respiratory infections. Acute exacerbation of chronic bronchitis. Acute pneumonia in children. Adult acute sinusitis. Gastrointestinal infections. Bacillary dysentery. Typhoid treatment (second line drug). Infections caused by Pneumocystis carinii. Trimackit is contraindicated in patients with severe renal failure whose plasma levels are not monitored, patients with confirmed megaloblastic anemia due to folic acid deficiency or patients who are sensitive to sulphonamides or trimethoprim; infants under 2 months old.

How to use Trimackit? Depending on the patient and the treatment goal, the dose of Trimackit will be different, specifically as follows:
Lower urinary tract infections:
Adults: 800 mg sulfamethoxazole + 160 mg trimethoprim, 12 hours apart in 10 days. Or sole therapy: 1600 mg sulfamethoxazole + 320 mg trimethoprim but minimally treat for 3 or 7 days. Children: 40 mg sulfamethoxazole/kg + 8mg trimethoprim/kg, given in 2 doses 12 hours apart, for 10 days. Chronic recurrent urinary tract infections:
Low dose 200mg sulfamethoxazole + 40mg trimethoprim daily or 2-4 times that dose, taken 1 or 2 times per week. Acute exacerbation of chronic bronchitis:
Adults: 800-1200 mg sulfamethoxazole +. 60-240 mg trimethoprim, 2 times daily for 10 days. Otitis media, pneumonia in children:
40 mg sulfamethoxazole/kg + 8 mg trimethoprim/kg for 24 hours, divided into 2 times daily, for 10 days.

In some patients when using Trimackit, side effects may occur such as:
Fever Nausea, vomiting, diarrhea Itching, rash, urticaria Anaphylactic reactions, serum sickness Aseptic meningitis Necrosis Toxic epidermal necrolysis (Lyell's syndrome), Steven-Johnson syndrome, erythema multiforme, angioedema, photosensitivity Jaundice, biliary obstruction Hyperkalemia, hypoglycemia Hallucinations Renal failure, interstitial nephritis, Tinnitus kidney stones The use of folic acid 5-10 mg/day can avoid side effects due to folic acid deficiency without reducing the antibacterial effect. To avoid the risk of the drug crystallizing into stones, the patient should drink enough water. Do not expose to the sun to avoid photosensitivity.

Some general notes when using Trimackit include:
When taking high doses of cotrimoxazol for a long time, it can cause kidney function decline, folic acid deficiency, dehydration, and malnutrition. Cotrimoxazole may cause hemolytic anemia in G6PD-deficient people. Sulfamethoxazole can cause jaundice in perinatal infants by pushing bilirubin out of albumin. If it is necessary to use Trimackit during pregnancy, it is important to take a folic acid supplement. Breastfeeding women should not take cotrimoxazole because the neonate is very sensitive to the toxic effects of the drug. Concomitant use of diuretics, especially thiazides, may increase the likelihood of thrombocytopenia in the elderly. Cotrimoxazole has the potential to unduly potentiate the effects of phenytoin. Cotrimoxazole may prolong prothrombin time when taking warfarin. The article has provided information on what Trimackit is used for, dosage and precautions for use. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Trimackit exactly as directed by your doctor. Store Trimackit medicine in a dry place, the temperature does not exceed 30 degrees Celsius and out of the reach of small children.