Uses of Vinphason

1 vial of Vinphason has 100mg of Hydrocortisone as the main ingredient in the form of hydrocortisone sodium succinate. Hydrocortisone is a corticosteroid hormone of the glucocorticoid group, which is secreted from the adrenal cortex. This active ingredient has the effect of preventing inflammatory, allergic, antipruritic and immunosuppressive reactions.
Glucocorticoids cross cell membranes and bind to specific receptors in the cytoplasm. These complexes then migrate into the cell nucleus, bind to DNA (chromatin) and stimulate the transcription of messenger RNA. Thus, it affects protein synthesis by various enzymes, which is considered to play an important role in the systemic effect of glucocorticoids.
Indications: Vinphason is used in the following cases:
Treatment of adrenal insufficiency using hormone replacement therapy; Treatment of symptoms for subjects suffering from muscle collagen disease such as polymyositis, acute rheumatic heart disease, disseminated lupus erythematosus; Treating patients in an emergency situation or unable to take drugs that need quick action such as: People with acute adrenal insufficiency or in emergency situations due to allergies such as shock, asthma,... Contraindications Indications: Do not use Vinphason in the following cases:
People with a history of hypersensitivity to one of the ingredients in Vinphason; Viral infections such as shingles, corneal herpes, chickenpox; bacterial infections such as tuberculosis; fungal or parasitic infections for which no specific drugs have been used; Patients with duodenal or gastric ulcer, renal failure, osteoporosis, severe hypertension; Women in the first 3 months of pregnancy.

Usage:
Vinphason is put into the body by infusion; When administering the drug, inject all the solvent in the ampoule into the vial of hydrocortisone 100mg powder with a sterile syringe and shake well until the drug is completely dissolved and then use immediately. Dosage:
Treatment of severe acute asthma: Intramuscular or intravenous infusion 3-4 times a day, each time 100 - 500mg Hydrocortisone depending on the needs of the patient; Treatment for patients with anaphylaxis: Adrenalin must first be injected into the body and then hydrocortisone intravenously with a dose of 100-300mg; In case of septic shock: The initial dose for intravenous administration is 1g for Hydrocortisone. If shock is life-threatening, an initial injection of 50mg/kg can be given, repeated after 4 hours or 24 hours as needed. Maintain high dose until patient is stable and do not use more than 48 - 72 hours; When intravenous infusion, when the patient is not limited in sodium, can mix 100mg of Vinphason drug solution into 100-1000ml of 5% glucose. Overdose: Overdose of Vinphason causes acute toxicity or leads to death, but very rarely. If there is an overdose, the patient should be handled and treated promptly.
Missed dose: Note to avoid forgetting dose of Vinphason. If a dose is missed, the patient should skip the missed dose and do not overlap the dose with the next dose. Be careful not to skip doses of Vinphason more than 2 times in a row.

Some side effects of Vinphason are:
When taking the drug for a long time, the most common undesirable effects are Cushing's syndrome and osteoporosis; Common side effects on the hormonal system such as: Growth retardation in children, Cushing's syndrome or inability to respond secondary to the adrenal cortex and pituitary gland; conditions of osteoporosis, muscle atrophy; Uncommon side effects: On the digestive system: Small bowel ulcers, peptic ulcers, bleeding ulcers,...; Nervous system: Depression, overstimulation, confusion when stopping the drug; Rare side effects: Immune system: Immune response or anaphylactic reaction with bronchospasm; On the nervous system: Symptoms of dizziness, dizziness, headache,...; On the skin: Wrinkled skin, contact dermatitis, slow healing of scars; On the digestive system: Nausea, vomiting, diarrhea; In case the patient encounters unwanted effects such as redness, itching or any other symptoms suspected of using Vinphason, they should consult their treating doctor for possible treatment. timely.

Some notes patients need to remember before and while using Vinphason:
Use only fast acting corticosteroids and increase the dose before, during and after stress; Prevention of corneal perforation in patients with ocular Herpes Simplex and panting syndrome in premature infants; It is necessary to add more potassium and limit salt in food when taking Vinphason; Caution should be exercised when using high-dose, long-term Vinphason for pregnant women, because it may cause suppression of the fetal adrenal cortex. Treatment with this drug before labor is very dangerous for premature babies; Vinphason should be used in combination with glucocorticoids to treat asthma in pregnant women; During the course of treatment with Vinphason, the patient should comply with the indications, not arbitrarily increase or decrease the dose of the drug; It is necessary to consult with the treating doctor before deciding to stop Vinphason.

Some Vinphason drug interactions to note:
Increases potassium deficiency if Vinphason is used at the same time with potassium-lowering diuretics such as furocemide or thiazides; Concomitant use of Vinphason and non-steroidal anti-inflammatory drugs increases the possibility of bleeding as well as peptic ulcer; Vinphason drug is metabolized and reduced in effectiveness when used concurrently with carbamazepine, phenytoin, barbiturates, rifampicin, primidone. Patients should list the drugs or dietary supplements being used at the time of treatment so that the doctor can understand and advise accurately, avoiding dangerous drug interactions.
During the use of Vinphason, the patient should pay attention to listen and follow the instructions from the treating doctor. At the same time, patients should not arbitrarily change the dose, route of administration, duration of drug use, ... to avoid unpredictable consequences.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.