Uses of Vinphatex

Vinphatex has the main ingredient is Cimetidine 200 mg, belongs to the group of anti-histamine H2 receptor drugs. Vinphatex drug is commonly used in cases of peptic ulcer disease and symptoms or diseases related to the gastrointestinal tract. Necessary information such as ingredients, uses, doses and side effects of Vinphatex medicine will help patients improve treatment effectiveness.

Vinphatex medicine is prepared under tablets, with the main ingredients including:
Active ingredient: Cimetidine 200mg. Excipients: Corn starch, Avicel PH101, Lactose, Magnesium stearate, Talc powder, Aerosil, Sodium lauryl sulfate just enough 1 tablet 200 mg, Mechanism of action
Active ingredient Cimetidine is a Histamine H2 receptor antagonist in cells gastric parietal cells, thereby reducing secretion and reducing acid concentration of the stomach both under basal conditions (when fasting) and when stimulated by Histamine, Pentagastrin, food, Insulin and Caffeine. In addition, this active ingredient also indirectly reduces Pepsin secretion by reducing gastric juice volume. However, some recent studies have shown that proton pump inhibitors are often more effective than histamine H2 receptor antagonists.

Vinphatex is indicated for the treatment of the following cases:
Healing of progressive benign gastric ulcers and progressive duodenal ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs) or stress. Maintenance treatment of duodenal ulcer after ulcer has healed to prevent recurrence. Esophagitis in patients with gastroesophageal reflux disease. Prophylaxis of upper gastrointestinal bleeding in people with diseases such as septic shock, severe trauma, respiratory failure, liver failure, severe burns... Zollinger-Ellison syndrome, systemic mastocytosis , multiple endocrine neoplasia. Persistent indigestion is not caused by stomach cancer. Prophylaxis of the risk of aspiration of gastric acid during childbirth (Mendelson's syndrome) or during general anesthesia. Reduce malabsorption or fluid loss in patients with short bowel syndrome. Decreased pancreatic enzyme breakdown in patients requiring this enzyme supplement.

Allergy to any ingredient of Vinphatex. History of allergy to other medicines containing Cimetidine. History of allergy to drugs belonging to the H2-antagonist group.

Dosage in adults:
Treatment of peptic ulcer: Initial dose: Take 4 tablets (800mg)/time as a single dose at night before going to bed, or take 2 tablets (400mg)/time x 2 times/day at breakfast or in the evening. Maintenance dose: Take 2 tablets (400mg) / time in the evening before going to bed or take 1 tablet (200mg) / time x 2 times / day in the morning or evening. The duration of treatment for gastric ulcers is at least 6 weeks, for duodenal ulcers is at least 4 weeks, for ulcers caused by taking NSAIDs is at least 8 weeks. Gastroesophageal reflux disease: Usual dose: Take 2 tablets (400mg)/time x 4 times/day with meals and at bedtime, or take 4 tablets (800mg)/time x 2 times/day. Duration of treatment is 4 to 8 weeks. Zollinger-Ellison syndrome: Usual dose: Take 2 tablets (400mg)/time x 4 times/day. The maximum dose can be used up to 12 tablets (2.4 g)/day. Prophylaxis of peptic ulcers caused by Stress: Usual dose: Take 1-2 tablets (200-400mg)/time x 4-5 times/day. Prophylaxis of gastric acid aspiration: In obstetrics: Take 2 tablets (400mg)/time at the beginning of labor. Then take 2 tablets (400mg) every 4 hours as needed. The maximum dose can be used up to 12 tablets (2.4g)/day. In surgery: Take 2 tablets (400mg)/time before pre-anesthesia. Non-ulcer dyspepsia: Usual dose: Take 1 tablet (200 mg)/time x 1-2 times/day. Short bowel syndrome: Usual dose: Take 2 tablets (400mg)/time x 2 times/day with breakfast or at bedtime. Decreased pancreatic enzyme breakdown in patients requiring this enzyme supplement: Usual dose: Take 1-2 tablets (200-400mg)/time x 4 times/day 60-90 minutes before meals. Dosage in children:
Children > 1 year: Take 25-30mg/kg/day in divided doses. Children < 1 year old: 20mg/kg/day in divided doses. Dosage in patients with renal failure is adjusted based on Creatinine clearance (CrCl):
CrCl 0 - 15ml/min: Take 1 tablet (200mg)/time x 2 times/day. CrCl 15-30ml/min: Take 1 tablet (200mg)/time x 3 times/day. CrCl 30-50ml/min: Take 1 tablet (200mg)/time x 4 times/day. CrCl > 50ml/min: Use the same dose as normal people.

Treatment with Vinphatex drug with high dose or prolonged, may cause side effects such as:
Common: Gastrointestinal disturbances such as diarrhea. Neurological symptoms such as dizziness, somnolence, fatigue, headache. Skin rash, enlarged breasts in men. Uncommon: Impotence, acne rash, urticaria, maculopapularity, transient elevation of liver enzymes, elevation of serum creatinine. Rare: Cardiovascular symptoms such as atrioventricular conduction block, increased or decreased heart rate. Blood abnormalities such as pancytopenia, aplastic anemia, neutropenia, agranulocytosis, thrombocytopenia. Neurological signs such as reversible confusion, depression, agitation, hallucinations, restlessness, disorientation. Signs of hypersensitivity such as Stevens-Johnson syndrome, allergies (including anaphylaxis), fever, vasculitis, toxic epidermal necrolysis. Skin symptoms such as exfoliative dermatitis, erythema, erythema multiforme, baldness, hair loss. Other signs such as jaundice, liver dysfunction, cholestatic hepatitis, acute pancreatitis, interstitial nephritis, myalgia, arthralgia, increased risk of hospital-acquired pneumonia, community-acquired pneumonia. Should stop using the drug when detecting the above side effects after taking Vinphatex. Patients and family members need to quickly notify the treating doctor about the use of Vinphatex or go to the nearest medical facility for timely treatment.
Note the use of Vinphatex in the following subjects:
Caution should be exercised when using Vinphatex in people with stomach cancer because it may mask symptoms, making it difficult to diagnose. Caution should be exercised when using Vinphatex in patients with a history of or severe renal impairment, galactose intolerance, glucose galactose malabsorption or lactase deficiency Lapps. Pregnant women: According to the US Food and Drug Administration (FDA), the active ingredient Cimetidine in Vinphatex is classified as safe group B, there is no evidence of a risk on pregnancy. In addition, cimetidine can cross the placenta, but its effects on the fetus are not well understood. Therefore, caution should be exercised when deciding to treat Vinphatex in this patient. Lactation: Currently, there are some studies indicating that Cimetidine in Vinphatex can be excreted in breast milk, but the harmful effects of the drug on the newborn are unknown. Therefore, it is recommended to use Vinphatex in pregnant women when absolutely necessary. Drivers or machine operators should not use Vinphatex before and during work because of possible side effects such as dizziness, drowsiness, fatigue, headache.

Interaction with other drugs:
Ketoconazole, Itraconazole reduces the absorption of Vinphatex. These drugs should be used at least 2 hours before taking Vinphatex. Vinphatex increases blood levels of the following drugs: Coumarin anticoagulants such as Warfarin. Tricyclic antidepressants such as Amitriptylin. Antiarrhythmic drugs such as Lidocaine. Calcium blockers such as Nifedipine or Diltiazem. Oral sulfonylurea such as Glipizide. Phenytoin Theophyllin Metoprolol Procainamide Metformin Ciclosporin Tacrolimus Vinphatex enhances the myelosuppressive effect of the following drugs: Carmustin Fluorouracil Epirubicin The above is general information and cautions when using Vinphatex. In order to bring the best treatment results for themselves and their families, users should carefully read the instructions for use of Vinphatex, and strictly follow the instructions of the specialist.