Uses of Yuhanonseran

Yuhanonseran is used to treat symptoms of nausea and vomiting of many causes, the main ingredient is Ondansetron, the active form, Ondansetron hydrochloride, 4mg. The drug is prepared in the form of disintegrating tablets in the mouth, contained in a box of 3 blisters, each blister of 4 tablets. So what is Yuhanonseran and how does it work clinically?

Yuhanonseran 4mg is used in the treatment of vomiting and nausea due to the pharmacological mechanism of the main drug Ondansetron. When entering the body, the drug selectively antagonizes serotonin 5-HT 3 receptors, thereby inhibiting serotonin receptors in the gastrointestinal tract.
The drug after oral administration is well absorbed from the gastrointestinal tract. The bioavailability of Ondansetron ranges from 48% to 75%, absorption is increased in the presence of food. At a dose of 8 mg, peak blood concentrations for men are 24.1 - 37 ng/mL and for women are about 42 ,7 - 52.4 ng/mL. In the blood, about 70% to 76% of the drug is bound to proteins. Ondansetron is metabolized mainly in the liver by enzymes present in the liver. Approximately 9% of the drug is excreted by the kidneys in the urine. The half-life of the drug in men is from 2.1 to 4.5 hours and in women is 1.9 to 8.2 hours (with the same dose of 8mg).

2.1. Indications Yuhanonseran 4mg is used in cases of feeling nausea, vomiting, vomiting caused by: radiation therapy, cytotoxic chemotherapy in cancer treatment, after the patient has surgical intervention. .
2.2. Contraindications Patients with hypersensitivity, allergy to Ondansetron or excipients of the drug.

How to use : The drug is taken orally, the patient can keep it in the mouth for the drug to dissolve gradually.
The drug should be taken with a meal because the pharmacological absorption of the drug is increased in the presence of food.
Dosage: Depending on the clinical case, the patient's health, the drug is used in different doses and intervals. You can refer to the recommended dosage from the manufacturer to use the drug dose in the causes of vomiting and nausea as follows:
For patients with vomiting, nausea due to chemotherapy or radiation therapy causing cytotoxicity Cells in the treatment of cancer:
Adults: The recommended dose is 8 - 32mg of oral dose per day.
For patients with mild vomiting during cancer treatment with chemotherapy or radiation therapy: The dose is 8mg before cancer treatment 1 to 2 hours and a follow-up dose of 8mg after. about 12 hours during cancer treatment. To prevent vomiting after cancer treatment, the maintenance dose is 8mg/time x 2 times/day, the duration of use should not exceed 5 days.
Patients with severe degree of vomiting during cancer treatment with chemotherapy, to prevent vomiting after treatment, the recommended dose is 16mg twice a day for less than 5 days.
Children over 2 years old: The daily dose is 8 mg divided into 2 times, the course of which is not more than 5 days. Children under 2 years of age: Currently, there are no specific clinical studies on the treatment of vomiting and nausea caused by chemotherapy and radiation therapy.
Elderly people, people with impaired renal function : Use the usual dose of Ondansetron.
Patients with liver failure : The recommended dose should not exceed 8mg of the drug per day.
For nausea and vomiting caused by surgery:
To prevent nausea and vomiting after surgery, the dose is indicated: Take a dose of 8mg 1 hour before anesthesia, and use it. Additional dose of 8mg x 2 times, every 8 hours.
Children and infants: Research on the effects of treating and preventing nausea and vomiting before and after surgery has not been specifically determined.
Elderly people over 65 years old, people with kidney failure: Usual recommended dose as adults.
Patients with impaired liver function: The daily dose should not exceed 8mg.

Hypersensitivity reactions: including signs of rash, itching of the skin, serious signs of anaphylaxis, and immediate hypersensitivity allergic reactions may occur, the patient should be carefully monitored. If these symptoms occur, the drug should be discontinued and an appropriate alternative treatment instituted.
Neuropsychiatric: Sometimes experiencing signs of headache, heaviness in the head, feeling hot in the stomach or head, drowsiness.
On the digestive tract: Diarrhea and constipation may occur. Cardiovascular: Chest pain, arrhythmia, hypertension or hypotension, bradycardia with or without palpitations.
Liver symptoms: Sometimes transient increases in liver enzymes AST, ALT, LDH, bilirubin.
Other cases such as blurred vision (rare), hiccups, flushing, fever may occur.

You need to inform, name the drugs and functional products you are using to the treating doctor to know whether to use Yuhanonseran or not, for example, the drugs phenytoin, rifampicin, carbamazepine that increase the clearance of the drug. . Note that the drug does not cause pharmacokinetic interactions when used in combination with alcohol, furosemide, temazepam, tramadol or propofol.
The drug contains an excipient is a synthetic sweetener, aspartame, patients with Phenylketouria need to control the amount of phenylalanine ingested into the body, because aspartame is converted to phenylalanine.
The drug can slow food down to the colon, so it is necessary to monitor in patients with intestinal obstruction after treatment.
Use caution when using Yuhanonseran for patients with severe hepatitis.
Overdose: There have been unusual reports when taking the drug including visual disturbances, hypotension, severe constipation and fainting syndrome, 2nd degree heart attack. Because there is no specific medicine for poisoning when taking the drug. Overdosage of the drug, therefore, the patient should have symptomatic treatment.
There have been no experimental studies using Yuhanonseran on the safety of pregnant women, should not be used during pregnancy like many other drugs. There have been reports of the drug being present in breast milk, therefore Yuhanonseran should not be used during breast-feeding.
The drug does not affect the ability to drive, use equipment, use machines.
Above is information about the drug Yuhanonseran. In order for the drug to be most effective in treating unpleasant symptoms of vomiting and nausea, you should know the basic information as in the above article. If you have any further questions, please contact the team of medical doctors, professional pharmacists for advice and help.