Uses of Ziusa

Ziusa drug with the main ingredient is Azithromycin 600mg in the form of Azithromycin IV granules 7.5% w/w. The drug is indicated for the treatment of patients with infections caused by susceptible strains of bacteria. Here is some useful information about Azithromycin to help patients use it safely and effectively.

Ziusa belongs to the group of drugs that treat parasites, anti-infectives, antivirals, and antifungals. Ziusa is manufactured in the form of a powder for oral suspension and packaged in a box of 1 vial.
Ziusa medicine has the main ingredient is Azithromycin 600mg along with some other excipients, just enough for 1 vial.

Ziusa is indicated for the treatment of infections caused by susceptible bacteria such as:
Treatment of lower respiratory tract infections such as pneumonia, acute bronchitis caused by Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae. Treatment of upper respiratory tract infections such as ear, nose and throat infections: Sinusitis. Pharyngitis, tonsillitis. Inflammation of the middle ear. Oral infection. Treatment of skin and soft tissue infections such as: Pimples, pustulosis, impetigo caused by Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae... Treatment of sexually transmitted infections in both men and women - bacterial infections uncomplicated genitalia caused by Chlamydia trachomatis, Neisseria gonorrhoeae. Use Ziusa in patients who are allergic to penicillin to reduce the risk of drug resistance. Treatment of chancroid caused by Haemophilus ducreyi. Use Ziusa in combination with Rifabutin to prevent MAC and with Ethambutol to treat MAC.

3.1. How to use Ziusa drug Ziusa drug is prepared as a powder for oral suspension, which is tolerated in the body orally.
Before use, shake the bottle well, dissolve the powder with a little warm water, stir well and drink.
Note: Take the medicine on an empty stomach, 1 hour before meals or at least 2 hours after eating.
3.2. Dosage of Ziusa Drug Dosage of Ziusa depends on each subject and the course of the disease. Below is a reference dose of Ziusa drug:
For adults:
In case the patient has upper and lower respiratory tract infections, skin and soft tissue infections: Use a single dose of 500mg Azithromycin in the first day. For the next 4 days, a single dose of 250mg Azithromycin is given per day. Patients with genital infections caused by Chlamydia trachomatis, Haemophilus ducreyi: The dose is 1000mg Azithromycin per day. Patients with infections caused by Neisseria gonorrhoeae: The dose is 1000mg or 2000mg Azithromycin with 250-500mg Ceftriaxone in 1 day. Use of Ziusa drug for the prevention of MAC infection: The dose used is 1200mg Azithromycin/time per week. Using Ziusa drug to treat MAC infection: The daily dose is 600mg Azithromycin. Patients should take with other Mycobacterium to increase the effectiveness of treatment. If there are other indications, treatment for 3 days, the daily dose is 500mg Azithromycin. Or treat for 5 days, the dose on the first day is 500mg Azithromycin, from the 2nd to 5th day take 250mg Azithromycin/day. For children:
In any case, the maximum dose of Ziusa drug is 1500mg Azithromycin per day for young children. The total dose is 30mg Azithromycin/kg body weight, can be divided into 3 oral days, used daily is 10mg Azithromycin/kg body weight. It can also be divided into the first day using 10mg Azithromycin/kg body weight, the following days using 5mg Azithromycin/kg body weight (from day 2 to day 5). For children with acute otitis media: Ziusa can be used at a dose of 30mg/kg body weight for 1 day. Treatment of strep throat in children: Use 10mg Azithromycin/kg body weight or 20mg Azithromycin/kg body weight for 3 days. The maximum daily dose should not exceed 500mg of Azithromycin. The more accurate the calculated dose, the more effective it will be. Dosage corresponding to the child's weight is as follows:
Children < 15kg: For 3 days, oral dose of 10mg Azithromycin/day. Azithromycin can also be used on the first day at 10mg, from day 2 to day 5 of 5mg Azithromycin. Children from 15kg -25kg: For 3 days, oral dose of 200mg Azithromycin/day. It can also be used on the first day with a dose of 200mg Azithromycin, then from days 2 to 5 every day 100mg Azithromycin. Children from 26kg - 35kg: Use Ziusa for 3 days, oral dose is 300mg Azithromycin/day. Can also be taken for 5 days, the first day of oral dose is 30mg Azithromycin, from 2nd to 5th day 150mg Azithromycin per day. Children from 36kg - 45kg: For 3 days, the dose is 400mg/day. Or take the first day 400mg Azithromycin, from day 2 to day 5, 200mg Azithromycin. Children from > 45kg: Use the drug according to the adult dosage. For children < 6 months: There is no information on the efficacy and safety of the drug. Therefore, the drug Ziusa should not be given to children in this age group. For the elderly, patients with renal impairment or mild liver failure do not need to adjust the dose of Ziusa.

Currently, there are still no reports and documents on cases of patients using Ziusa drug overdose. Typical symptoms of an overdose of Macrolide antibiotics are usually:
Hearing loss. Nausea, vomiting and diarrhea. There is still no specific treatment when the patient overdose of Ziusa drug. It should be treated with gastric lavage and supportive treatment.

Ziusa should not be used for patients with hypersensitivity to Azithromycin, Erythromycin, Macrolide or Ketolide antibiotics or any other excipients of the drug. Do not take Ziusa with Ergotamine and Bromocriptine.

Some interactions of the drug Ziusa 200mg/5ml may occur such as:
Do not use Ziusa with food will reduce the bioavailability of the drug by up to 50%. Do not use Azithromycin concurrently with ergot derivatives: Will increase Ergotin toxicity. Should not be combined with antacids: Because the peak concentration of Antacid is reduced by 24%. Do not use the drug with Digoxin, Cyclosporin: It will cause an increase in the concentration of P-glycoprotein in the serum, increasing the peak plasma concentration of the drug. Patients need to monitor and adjust the dose when taking these drugs simultaneously. Coumarin-type anticoagulants: Increases the anticoagulant effect of these drugs. Warfarin and Azithromycin can be used simultaneously, but the patient's anticoagulant time must be monitored. When using Ziusa in combination with Rifabutin, although it does not affect the blood concentration of both drugs, it will reduce neutrophils. When using the combination of Azithromycin and Theophylline, there is no clinically significant interaction, but it is still necessary to monitor the concentration of Theophylline when using these two drugs for patients. Co-administration with Carbamazepine, Cimetidine, Methylprednisolone: ​​The Azithromycin component of the drug has little effect on the pharmacokinetics of Carbamazepine, Cimetidine, and Methylprednisolone. Using Ziusa drug Zidovudine: Increases the concentration of Zidovudine drug. Taking Ziusa with Atorvastatin: May cause rhabdomyolysis. Using Ziusa with Fluconazole: There was no pharmacokinetic interaction, but there was a slight decrease in the peak Cmax (18%) of Azithromycin. Using Ziusa with Nelfinavir: Will increase the concentration of Azithromycin. Before using Ziusa for treatment, patients need to inform their doctor about the drugs and functional foods being used to have the most effective treatment direction, to avoid unwanted interactions.

The drug is well tolerated. Most of the side effects when using Ziusa are moderate to mild. During the use of Ziusa, patients may experience some unwanted side effects such as:
Common: Digestive disorders with symptoms such as: Abdominal pain, abdominal cramps, indigestion, flatulence, diarrhea, nausea, vomiting. Rare cases of taste disorders, nephritis, vaginitis...; side effects of Macrolid on nerves such as headache, drowsiness, dizziness, dizziness, fatigue...; appearance of rash, edema, photosensitivity, peripheral angioedema....on the skin. Causes reversible hearing loss in patients receiving long-term high doses of Ziusa. Causes a transient, transient decrease in neutrophil counts during clinical trials, but a relationship with drug use has not been established. Reversible increases in hepatic transaminases such as: Hepatitis, cholestatic jaundice have been reported. All cases of the above side effects of the drug were gradually reduced and disappeared when the patient stopped taking Ziusa drug. When any unwanted side effects appear on the patient, it is necessary to notify the doctor immediately for timely help.

Need to adjust the dose of Ziusa drug suitable for patients with liver and kidney failure (ClCr <40 ml/min). For patients with severe renal impairment (filter level < 10ml/min) may have increased drug concentration in the blood when used. Risk of superinfection with non-susceptible bacteria and pseudomembranous colitis with broad-spectrum antibiotics such as Azithromycin. Caution because Azithromycin has the potential to cause allergies such as: Angioedema and anaphylaxis although very rarely. Pregnancy: Animal studies have not shown any harmful effects on pregnancy. However, there is still insufficient evidence for human use. Therefore, it is necessary to consult a doctor when it is necessary to use the drug. For women who are breastfeeding: Ziusa is excreted in breast milk. However, there are no adequate studies on using Ziusa in this population. Therefore, consult your doctor before use. In the process of using the drug, if the patient has any questions, it is necessary to inform and consult a doctor. Note, keep the medicine out of reach of children and pets. Store Ziusa medicine in a dry place, the temperature is below 30 degrees Celsius. The basic information about Ziusa in the above article is for reference only. Because this is a prescription drug, the patient should not arbitrarily use Ziusa, but need to contact a specialist doctor directly for a suitable prescription, ensuring safety for health.