Uses of Zoralon

The active ingredient Zoralon is Palonosetron, which is commonly used to prevent nausea caused by chemotherapy. Patients using Zoralon often experience some undesirable effects such as headache, abdominal pain, constipation, ...

What is Zoralon? Zoralon is classified as an gastrointestinal drug manufactured by Cipla Ltd., India. Zoralon has the active ingredient Palonosetron (as Palonosetron hydrochloride).
Dosage form: solution for injection, content of 250mcg Palonosetron/5ml Packing: 5ml vial, each box includes 1 vial and instruction sheet.

Pharmacodynamics: The antiemetic Zoralon is highly selective for the Serotonin 5HT-3 receptor, with little effect on other Serotonin receptors. Zoralon has a peripheral blocking effect on the vagus nerve endings and is concentrated in the active receptor excitatory zone. In nonclinical trials, Zoralon was able to block ion channels involved in ventricular depolarization, repolarization, and action potential prolongation.
Pharmacokinetics:
Absorption: Zoralon is well absorbed orally with a bioavailability of 97%. A high-fat diet does not affect peak plasma concentrations. Therefore, Zoralon can be taken independently of a meal. Distribution: Zoralon is widely distributed in the body, binding to plasma proteins is 62%. It is not known whether the drug passes into breast milk. Metabolism: Zoralon is metabolized primarily by the CYP2D6 system to two major metabolites. Elimination: Zoralon is eliminated in the urine as unchanged drug about 40%. The half-life ranges from 20 to 30 hours after a dose of 20 mcg/kg. Hepatic, mild and moderate renal impairment did not affect the clearance of Zoralon in the body.

Zoralon is usually indicated in the following cases:
Prevention of acute or delayed nausea and vomiting caused by cancer chemotherapy causing moderate to severe vomiting. Who should not take Zoralon?
Do not use Zoralon for patients who are sensitive to any ingredient of the drug

In order for Zoralon to promote its effectiveness in treatment and reduce risks during drug use, you need to follow your doctor's instructions about the time of taking the drug, the route of administration and the dose. Do not change your medication regimen on your own, share Zoralon with others, or share it with others when they have the same condition as you.
Dosage: 250mcg/time. Dosage: Intravenous injection of a single dose over 30 seconds. Inject about 30 minutes before starting chemotherapy. Attention: clean the line before and after using Zoralon with physiological saline.
What to do in case of an overdose of Zoralon?
In clinical trials, the group taking the highest dose up to 6 mg had a similar frequency of adverse events with the group taking the lower doses. No dose-response relationship was found. When an overdose of Zoralon is suspected, supportive treatment should be given to the patient.

In addition to the therapeutic effect of reducing vomiting, Zoralon may cause some other undesirable effects during use such as:
Common: constipation, headache, ... Uncommon: sleep disturbance sleep, anxiety, agitation, paresthesia, eye swelling, atrioventricular block, dyspnea, nausea, constipation, myalgia, transient elevation of liver enzymes, hyperbilirubinemia, ... Rare: hypersensitivity, reaction injection site reactions such as burning, pain, induration, discomfort, etc. These are not all side effects of Zoralon , you may experience others that have not been listed or studied. . Therefore, notify your doctor as soon as any unusual symptoms appear to be treated quickly.

Treatment with many drugs can cause interactions between drugs, the result can reduce the effect, even increase the toxicity of the drug. To be on the safe side, tell your doctor about all medications you are taking or have recently stopped taking, including prescription and over-the-counter medicines, vitamins and minerals, herbal products, and foods. function. Some drugs interact with Zoralon such as L-Tryptophan, Amphetamine, Phentermine, Ziprasidone, Cabergoline, Morphine, Valproic Acid, Zolmitriptan, Codeine, Hydromorphone, ...

Using Zoralon in pregnancy: no harmful effects on pregnancy and childbirth, fetal development after birth in laboratory animals have been found. There is insufficient evidence on the safety of using Zoralon during pregnancy. Therefore, Zoralon should not be used during pregnancy, unless absolutely necessary and prescribed by a doctor. Use of Zoralon during lactation: It is not known whether Zoralon is excreted in human milk. Therefore, Zoralon should not be used during lactation. Zoralon may cause dizziness, somnolence, and fatigue, so caution should be exercised when using it in patients who drive, operate machinery or perform work at height. Zoralon may decrease intestinal motility, so caution should be exercised in patients with a history of constipation or signs of semi-obstruction after administration. Zoralon should be used with caution in the following cases:
History of prolonged QT interval Electrolyte abnormalities Congestive heart failure Cardiac arrhythmias Conduction disturbances Taking antiarrhythmic drugs Hypokalemia

Keep Zoralon medicine in a cool, dry place, away from direct light. Keep Zoralon out of reach of children and pets. Zoralon has the active ingredient Palonosetron, which is commonly used to prevent nausea caused by chemotherapy. Patients using Zoralon often experience some undesirable effects such as headache, abdominal pain, constipation. Therefore, during use, the patient should strictly follow the instructions of the doctor and the medical staff performing the infusion.
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