What diseases does Zuryk treat?

Zuryk medicine has the main ingredient is Allopurinol. The active ingredient Allopurinol and its metabolite oxypurinol reduce uric acid production by inhibiting xanthin oxidase, the enzyme that converts hypoxanthine to xanthin and converts xanthin to uric acid. Therefore, the drug Allopurinol reduces the concentration of uric acid in the serum and in the urine.
Uric acid is a breakdown product of purines in food. They form crystals in the body's tissues that cause gout. Elevated blood uric acid can also cause kidney disease and kidney stones. Accordingly, Allopurinol is used to prevent kidney stones caused by uric acid and to prevent exacerbations of gouty arthritis.
Absorption: Allopurinol is almost completely absorbed from the gastrointestinal tract and reaches maximum concentrations 4 hours after oral administration. Distribution: Zuryk is poorly bound to plasma proteins, volume of distribution is 0.6 l/kg. Metabolism: The active ingredient Allopurinol is converted to the active oxypurinol. Elimination: Zuryk is excreted in the urine as metabolites, with a mean half-life of about 1 hour (oxypurinol 18-20 hours).

Zuryk is indicated in the treatment of the following conditions:
Long-term treatment of hyperuricemia caused by chronic gouty arthritis. Uric acid nephrolithiasis (with or without gouty arthritis). Treatment of recurrent calcium oxalate stones in men with urinary urate excretion greater than 800 mg/day and 750 mg/day. Increased uric acid in the blood when conducting chemotherapy for cancer treatment in leukemia, lymphoma, melanoma.

Side effects when using Zuryk medicine, including:
Most common effects:
Rash, skin rash. Uncommon effects:
Nausea, vomiting, changes in liver function test indicators. Rare effects
Hepatitis. Very rare effects:
Ataxia, confusion, headache, neuralgia, paralysis; Dizziness, angina pectoris ; Hematuria, uremia; Hair loss, hair discoloration; Gynecomastia in men, infertility, infertility; Body weakness, fever, edema, general malaise; Cataracts, visual disturbances, optic neuritis; Seizures, myoclonus, hypotonia, dystonia, tremor; Immunoblastoma - vascular; Diabetes, hyperlipidemia. When you experience the following reactions, it is necessary to stop using the drug completely and notify the treating doctor immediately:
Severe allergic or hypersensitivity reaction; Rash, rash and severe skin changes; Swelling of the face, lips, tongue and throat; Fever, swollen lymph nodes, joint pain, angioedema, hepatitis, blood damage, or fainting.

4.1. How to use Zuryk The patient needs to take the drug orally, take it with meals and drink a lot of water. With another dose that is not suitable for the content of the preparation (Zuryk 300mg tablets), you should choose another more suitable dosage form. Before taking Zuryk, you can take an anti-inflammatory drug or colchicine to prevent an acute gout attack. If Allopurinol is used to treat cancer, it should be used before treatment with other cancer drugs. 4.2. Dosage of Zuryk The dose of Zuryk should be according to the doctor's prescription. The reference dose according to the manufacturer's instructions is as follows:
Adults: Initial dose of 100 - 300 mg/time/day or 1 tablet of Zuryk 300 mg/time/day and can be increased to 200 - 600 mg/day and divided into several doses, up to a maximum of 800 mg/day. Children: 10-20 mg/kg/day. Elderly or kidney disease: The treating doctor will adjust the dose accordingly. 4.3. How to handle a missed dose, overdose Zuryk 300mg When you forget a dose of Zuryk 300mg, you need to take the replacement dose as soon as you remember. If the time interval between the missed dose and the time of the next dose is close, skip the missed dose. It should be noted that do not take a double dose to make up for it. When you overdose on Zuryk 300mg, you may experience symptoms including nausea, vomiting, diarrhea, dizziness. The way to handle it is that you need to immediately go to the nearest medical facility for timely monitoring and treatment. Your doctor may recommend procedures such as gastric lavage, hemodialysis, and peritoneal dialysis. In addition, Zuryk 300mg poisoning has no specific antidote, you need supportive care and stay hydrated.

Zuryk drug interactions occur that may increase unwanted effects or reduce the therapeutic effect of drugs. Zuryk drug may interact when used with the following drugs:
Azathioprin: treatment of rheumatoid arthritis and after organ transplantation. Ciclosporin: treatment of psoriasis, rheumatoid arthritis and post-organ transplantation. 6-mercaptopurine: medicine to treat certain cancers and intestinal diseases. Cyclophosphamide, doxorubicin, bleomycin or procarbazine: treatment of leukemia and some cancers. Probenecid: treatment of gout. Phenytoin: treatment of epilepsy. Theophylline: treatment of bronchial asthma. Antibiotics Ampicillin, Amoxicillin. Aspirin, salicylates. Warfarin: anticoagulant. Clopropamide: treatment of diabetes mellitus. Didanosin: antiviral drug. Diuretics to treat high blood pressure such as: Captopril. Medicines for indigestion should be taken at least 3 hours apart from Zuryk 300mg. For the safe and effective use of Zuryk in treatment, you should list with your doctor all medications, including those that you are currently taking. At that time, the treating doctor will help you adjust and replace the drugs that are suitable for your health condition.

Use for pregnant and lactating women:
Pregnant or breastfeeding women are advised not to use Zuryk to treat the disease. Laboratory studies conducted in animals have shown teratogenic effects. This is because the drug is likely to be excreted in breast milk. In case of necessity and mandatory use of Zuryk, the treating doctor or clinical pharmacist only prescribes it when the favorable and possible risk factors have been screened during treatment with Zuryk. 300mg . People who drive and operate machinery: Zuryk 300mg medicine can cause side effects such as visual disturbances, headache, dizziness, fatigue... Do not drive and operate machinery if you experience any of the following: this sign. Other Special Notes
Read the instructions carefully before taking Zuryk . The treating doctor may prescribe a dose reduction when using the drug in the elderly or with liver and kidney diseases. If you experience severe skin rash, stop using the medicine completely and contact your doctor immediately. In addition to treating gout with drugs, it is necessary to combine it with a reasonable and scientific diet. Zuryk contains Lactose, which should be used with caution in people who are intolerant to sugar. Storage conditions:
Store Zuryk 300mg in a cool, dry place, away from direct light. Keep out of reach of small children and household pets. Never use Zuryk after the expiry date printed on the package. Zuryk contains the active ingredient Allopurinol. This medication is used to treat gout and other conditions related to the elimination of uric acid from the body. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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