What does Claminat do?

The main ingredients of Claminat 625 mg are Amoxicillin and Clavulanic Acid. Amoxicillin is a β-lactam antibiotic that inhibits bacterial cell wall synthesis. Amoxicillin has a broad bactericidal spectrum against many Gram-positive and Gram-negative bacteria. However, Amoxicillin is easily destroyed by β-lactamase enzymes, so it is not effective against bacteria that produce these enzymes.
Clavulanic acid has the ability to inhibit the enzyme β-lactamase, which prevents Amoxicillin from being destroyed by β-lactamase, and at the same time expands the antibacterial spectrum of Amoxicillin.

Drug Claminat 625mg is indicated for the treatment of infections in adults and children such as:
Ear, nose and throat infections: tonsillitis, sinusitis, otitis media. Lower respiratory tract infections: Acute and chronic bronchitis, bronchial pneumonia. Genitourinary tract infections: Cystitis, urethritis, pyelonephritis (female genital tract infection). Skin and soft tissue infections: boils, abscesses, wound infections, insect stings, cellulitis. Bone and joint infections: Osteomyelitis. Dental infection: Alveolar abscess. Other infections: Infections caused by abortion, obstetric bacteremia, intra-abdominal infections.

Undesirable effects of Claminat such as:
Common: Diarrhea, skin itching, nausea, vomiting. Uncommon: hepatitis, cholestatic jaundice, eosinophilia, rash, increased transaminases. Rare: Anaphylactic reactions, leukopenia, hemolytic anemia, pseudomembranous colitis, Stevens-Johnson syndrome, interstitial nephritis.

Claminat 625mg is contraindicated in patients:
Hypersensitivity to the components of the drug or antibiotics of the Penicillin, Cephalosporin group. Has a history of jaundice. Liver failure.

Signs and symptoms of cholestatic jaundice are rare with the drug but can be severe. However, these symptoms are usually reversible and resolve after 6 weeks of stopping Claminat. Serious and sometimes fatal hypersensitivity reactions (anaphylaxis) have been reported in patients receiving penicillins. Erythema (multiple) associated with lymphadenopathy (infectious mononucleosis) has been reported in patients receiving amoxicillin. Therefore, the drug should be avoided if infectious mononucleosis is suspected. Prolonged use of the drug can lead to the development of resistant bacteria. Pregnancy: Experimental studies on the reproduction of rats have demonstrated that oral administration of the product does not cause malformations. However, because there is little experience with the use of the drug in pregnant women, it should be avoided in pregnant women especially during the first 3 months of pregnancy, unless clearly indicated by the doctor. Lactation: During lactation, the drug can be used. Small amounts of the drug may diffuse into breast milk, posing a risk of sensitization to the infant. Care should be taken when taking the drug. Inform physician if patient is breast-feeding. Claminat medicine 625mg is an antibiotic used in the treatment of ear, nose and throat infections, lower respiratory tract infections, urinary tract infections, and genitals. To ensure the effectiveness of treatment as well as avoid side effects, patients need to take medicine according to prescription or as directed by a doctor or pharmacist.
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