What does Foban cream do?

Foban cream is indicated for Penicillin-resistant cases such as abscesses, bone and joint infections,... The following article will help you better understand what Foban cream has and what to note when used to ensure safety and efficiency.

Foban cream with the main ingredient is Fusidic Acid, which is produced in the form of a tube for topical application of 5 grams, 15 grams, and 20 grams. Fusidic acid is prescribed for skin infections caused by bacteria (impetigo, cuts, dermatitis). It works by stopping the growth of germs that cause infections. Foban cream is an antibacterial preparation that usually clears up skin infections quickly, especially when the infection covers only a small area. If the infection is more widespread, an antibiotic pill or injection may be needed.
If the skin is infected, your doctor may prescribe a cream that combines fusidic acid with an anti-inflammatory agent, such as hydrocortisone or betamethasone.

2.1. Mechanism of action Foban cream Fusidic acid disrupts the translocation of peptide subunits and elongates the peptide chain of susceptible bacteria, thereby inhibiting protein synthesis. The mechanism of action of the drug Foban cream is as follows:
Absorption: Absorption in children is faster than in adults. At achievable serum concentrations, post-antibiotic effect is 0.8 - 1.75 hours for S. aureus and 1 hour for Streptococcus pyogenes. Distribution: Widely into body tissues and fluids, including bone, pus and synovial fluid, crosses placenta, enters breast milk. Metabolism: Metabolized in the liver with biliary excretion being the most likely route of elimination. Examination of the bile metabolites of fusidic acid revealed that it is a glucuronide conjugate and a carboxylic derivative. A variety of minor metabolites are produced, including hydroxy, 3-keto metabolites and 3 others that have yet to be identified. Excreted in bile (mainly as metabolites), feces (2% as unchanged drug) and urine. The half-life is 5 to 6 hours. The pharmacokinetics of fusidic acid in patients with severe renal impairment requiring dialysis are not substantially different from those with normal renal function as would be expected for a drug with minimal renal clearance. The drug is not eliminated by hemodialysis and the concentration in the peritoneal dialysis fluid is low (<2.3 mg/l). Accumulation of metabolites has not been demonstrated in these patients.
The pharmacokinetics of fusidic acid are altered in patients with celiac disease with a 60-70% increase in maximal AUC and C compared with normal subjects. In patients with low albumin status, the increased clearance is probably due to decreased protein binding resulting in greater drug metabolism. In contrast, decreased clearance occurs with severe cholestasis, the mechanism suggested by competition of excess bilirubin for glucuronidation.

2.2. Indications to use Foban cream Foban cream is indicated for treatment in the following cases:
Used topically for patients with lesions caused by primary or secondary Staphylococcus or Streptococcus infections; Treatment of penicillin-resistant cases such as abscesses, bone and joint infections, Staphylococcus infections in patients with pancreatic cystic fibrosis, Staphylococcus endocarditis. Used in combination with other antibiotics; Topical drug, indicated for eye and skin infections such as interstitial rash, impetigo; Treatment of skin infections caused by staphylococcus, streptococcus and bacteria that react to the active ingredient Fusidic acid. 2.3. Contraindications of Foban cream Do not use topical Foban cream in the following cases:
Skin infections caused by viruses, bacteria, tuberculosis or fungi; Skin ulcers to be treated; People who are allergic or hypersensitive to the ingredients in Foban cream; Corticosteroids are contraindicated in cases of viral, tuberculosis and fungal skin infections, rosacea, perioral dermatitis, skin ulcers, hypersensitivity to any ingredient of Foban cream. You need to consult with your doctor if you intend to give the drug to a child, to control the smallest risks that may arise.

There are a small number of cases where unwanted side effects occur when using Foban cream. In some special cases, reactions may include:
Redness, itching at the application site; Headache; Nausea; Heart beats fast. You should tell your doctor as soon as you have any problems after applying the medicine.

Inform your doctor about any medications you are taking, including over-the-counter, herbal or dietary supplements, before starting treatment with Foban cream.
Some possible drug interactions include:
Fusidic acid should not normally be taken with cholesterol-lowering drugs, eg Atorvastatin and Simvastatin, as it may increase the risk of muscle damage (myopathy) ). If you are taking Statins and your doctor has ordered you to use Foban cream at the same time, monitor and inform your doctor about any unexplained muscle symptoms, such as pain, cramps, and pain. muscle withdrawal or weakness. Fusidic acid may increase blood levels. As this may increase the risk of bleeding, people taking Foban cream with anticoagulants should regularly monitor their blood clotting time (INR). If Foban cream is used in combination with protease inhibitors to prevent HIV infection, such as Ritonavir or Saquinavir, blood levels of both drugs may be increased. This increases the chance of side effects from either drug. Typhoid vaccine should not be given for at least 3 days after you finish a course of treatment, as Foban cream topical may make the vaccine less effective. Previously, women using hormonal contraception such as the pill or patch would be advised to use an additional method of contraception (eg condoms) while taking fusidic acid and for 7 days after. finish the course. However, currently you do not need to use another method of birth control while taking a course of Foban cream because there are not many studies to prove the effect.

Foban cream 5g or 15g is prepared in the form of a cream tube, so patients use the drug by applying it directly to the skin.
How to use Foban cream as follows:
Wash your hands and clean the affected skin area, then pat dry with a clean towel; After contact with Foban cream, you should wash your hands with soap again; Only when prescribed by a doctor, the treated skin area can be covered with a bandage; Limit contact of your infected skin with other people; Wear loose-fitting clothes to avoid friction with the skin where the medicine is to be applied. Use the drug with an average frequency of 2 to 3 times / day, continuous treatment for about 7 days. If you treat acne, it may last longer than for other conditions.
In summary, Foban Cream is indicated in cases of primary or secondary Staphylococcus and Streptococcus skin lesions. When using Foban Cream, you may experience unwanted effects (ADRs). Therefore, you need to use the drug as prescribed by your doctor to ensure safety and effectiveness.