What is Erdosteine ​​300mg?

What is Erdosteine? The composition of the hard capsule erdosteine ​​300mg contains the active ingredient erdosteine ​​300mg and excipients such as: Microcrystalline cellulose, Povidone K-30, Magnesium stearate...
Erdosteine ​​300mg is a mucolytic drug indicated for to dilute sputum in cases of acute and chronic respiratory diseases. Erdosteine ​​300mg is used only with a doctor's prescription.
Erdosteine ​​300mg is used with a dosage of 1 tablet / time, 2-3 times / day. When taking Erdosteine ​​300mg, patients should swallow the tablet whole with a glass of water, before or after eating.

Erdosteine ​​300mg is contraindicated in the following cases:
Hypersensitivity to any ingredient in erdosteine ​​300mg; Patients with cirrhosis of the liver, deficiency of the enzyme cystathionine-synthase; Severe renal impairment with creatinine clearance < 25ml/min; Pregnant women and lactating women should not take erdosteine ​​300mg (due to insufficient data on safety).

The following cases need extreme caution when using erdosteine ​​300mg :
Patient is suffering from stomach ulcer ; People with kidney and liver disease; Caution should be exercised when erdosteine ​​300mg is used in patients under 18 years of age.

The rare adverse effects (incidence less than 0.01% of total users) of erdosteine ​​300mg are:
Stomach pain; Shortness of breath; A cough; Diarrhea; Eczema; Headache; Vomit; Skin rash; Changes in taste ... Due to the side effects of headache and dizziness, erdosteine ​​300mg should be used with caution when patients need to perform tasks requiring alertness such as driving and operating machinery. . For patients taking more than the recommended dose (900mg of erdosteine/day) may experience sweating, dizziness and flushing. Gastric lavage should be performed within 1 hour of an overdose of erdosteine ​​300 mg, after which the patient should be closely monitored.

There are no reports of interactions of erdosteine ​​300mg with other drugs. Clinically, erdosteine ​​300mg can be combined with antibiotics, bronchodilators (Theophylline...), β2-adrenergic receptor stimulants, cough suppressants...

Erdosteine ​​is a derivative of mercapto-amino acid, exists in the form of thiolactone, this is a prodrug that, after entering the body, will be converted into an active form and give mucolytic effects. Erdosteine ​​has the effect of stabilizing mucus secretion, thinning sputum, making it easier for patients to spit out sputum (thanks to the free thiol groups in the Erdosteine ​​metabolite, which will cleave disulfide bridges of bronchial mucoproteins). Erdosteine ​​is an active ingredient with bronchoprotective effects, protecting the enzyme α1-antitrypsin by increasing the amount of IgA antibodies in the blood, increasing the ability to fight bacteria. In addition, this free thiol group of Erdosteine ​​is also capable of inactivating oxidants, especially the inactivation of free radicals.
The advantage of the drug Erdosteine ​​300mg compared to other drugs of the thiol group is that it is less irritating to the stomach because the thiol group (SH) in the erdosteine ​​molecule has been blocked by other groups.
After entering the body Erdosteine ​​is rapidly absorbed after oral administration, about 64.5% of the amount of Erdosteine ​​will be bound to plasma proteins. Erdosteine ​​is eliminated mainly in the urine as a sulfate conjugate. Food has little effect on the absorption, metabolism and excretion of erdosteine ​​300mg. Accumulation of erdosteine ​​and its metabolites with repeated dosing has not been adequately demonstrated.
Store erdosteine ​​300mg at room temperature, away from moisture, protect from light and do not store erdosteine ​​300mg in the bathroom or in the freezer compartment. Carefully read the instructions for storing erdosteine ​​300mg on the packaging or ask your pharmacist to keep erdosteine ​​300mg out of the reach of children and pets. Before using erdosteine ​​need to carefully weigh the risks and benefits, consult your doctor for detailed information before using erdosteine ​​300mg.
Erdosteine ​​300mg medicine is used for symptomatic treatment of acute cough in chronic bronchitis. To ensure the effectiveness of treatment, patients need to take medicine according to prescription or consult a doctor or pharmacist.