What is Flucinar? Usage and usage

Flucinar is an ointment containing the active ingredient Fluocinolone acetonide, indicated for the short-term treatment of the acute or chronic conditions of glucocorticoid-responsive atopic dermatitis, seborrheic dermatitis, urticaria, hereditary dermatitis... Let's find out the use and use of Flucinar through the article below.

1.1. Indications "What is flucinar drug?". Flucinar is an ointment containing the active ingredient Fluocinolone acetonide, which is indicated in the treatment of the following conditions:
Short-term treatment of acute or severe conditions of non-infectious atopic dermatitis. response to glucocorticoids, persistent pruritus, keratosis; Treatment of hereditary inflammatory skin conditions, seborrheic dermatitis, eczema, lichen urticaria, lupus erythematosus, erythema multiforme, lichen planus and perennial psoriasis. 1.2. Pharmacodynamics Fluocinolone acetonide is a synthetic corticosteroid with a fluorine atom attached to the steroid nucleus, with moderate to moderate potency. The mechanism of action of fluocinolone acetonide in particular and topical corticosteroids in general is a combination of 3 important effects including antiallergic, anti-inflammatory and vasoconstrictor. Anti-inflammatory effect through the mechanism of reducing the formation and inhibiting the release, limiting the effect of vasoconstricting compounds released during inflammation (histamines, kinins, prostaglandins, lysosomal enzymes, components) complement and leukotrienes). The vasoconstrictor effect of the drug helps to reduce fluid leakage at the site of inflammation. In addition, steroids also reduce the permeability of cell membranes.
Fluocinolone acetonide causes collagen accumulation, increases protein synthesis while promoting protein breakdown in the skin, slowing down the proliferative processes. In addition, steroids (especially those containing molecular fluoride) have an anti-mitotic effect on epidermal cells. Repeated use of these drugs will reduce the effect of the drug on the skin, which leads to a longer time for the drug to take effect, an increase in systemic absorption, and an increased risk of unwanted effects. would like.

1.3. Pharmacokinetics Absorption: Topical corticosteroids are used only when the skin is intact; small amounts are absorbed to the dermis and then into the general circulation. However, systemic absorption is increased when the skin loses its keratin layer, has diseases of the epidermal barrier (eg, eczema, psoriasis) or is inflamed. The extent of drug absorption depends on the condition of the skin where the drug is applied, the degree of penetration and the amount of drug applied. In particular, the absorbable drug is most easily absorbed in the eyelid skin (40%), scrotum (36%), forehead (7%), forearm (1%), head (4%) and skin folds. . The presence of Fluocinolone acetonide in the body is found after about 15 days of taking the drug.
Metabolism: Topical corticosteroids are not metabolized in the skin. When used as directed, a small amount of the drug will be absorbed into the body's circulatory system and metabolized in the liver to form inactive substances.
Elimination: Fluocinolone acetonide is eliminated by the kidneys as sulfate, glucuronide and unconjugated form. Small amounts of metabolites are excreted in the feces.

Besides answering the question "what does flucinar do?" The patient also needs to know the dose and how to use flucinar. Accordingly, the recommended dose of the drug is as follows:
Apply a small amount of the drug to the infected skin, the frequency of application should not exceed 1-2 times a day. Note that the skin should not be covered after applying the medicine (except in the case of psoriasis); Do not use the drug continuously for more than 2 weeks for the skin on the body and not more than 1 week for the face. Do not use more than 1 tube in a week; Use caution when using topical flucinar in children under 2 years of age (use only when absolutely necessary as prescribed by a doctor).

Some undesirable effects may be encountered when using topical flucinar as follows:
Purpura, acne, atrophy of subcutaneous tissue, inhibition of epithelial growth, dry skin, hair loss or excessive hair growth, vasodilation, skin discoloration, atrophy or cracking of the skin; In some cases, urticaria, skin lesions or maculopapular rash may appear; If the bandage is closed after applying the drug, it will increase the absorption of the drug into the body, leading to unwanted effects such as angioedema, immunosuppression, increased blood pressure; Using the drug in the eyelid skin area can lead to cataracts or glaucoma.

4.1. Contraindications Contraindicated to use topical flucinar in the following cases:
Skin infections, viral infections, fungal infections, rosacea, seborrheic dermatitis, perioral dermatitis; The patient has just been vaccinated; Patients with hypersensitivity to fluocinolone acetonide, glucocorticosteroids or excipients of the drug; Children under 2 years old. 4.2. Notes on use Some notes when using flucinar drugs are as follows:
Do not use the drug continuously for more than 2 weeks because it increases the risk of side effects such as hypertension, edema, weakened immune system; Risk of decreased secretion of adrenocorticotropic hormone ACTH with fluocinolone acetonide, resulting in decreased serum cortisol levels and Cushing's syndrome. Usually this will go away when the drug is stopped; In case the patient has a fungal or bacterial infection at the injection site, it should be treated with an appropriate antibacterial or antifungal drug; Minimize the use of drugs in the skin near the eyelids in patients with narrow-angle and wide-angle glaucoma, cataract patients because of increasing disease symptoms; Only use the drug on the skin of the face and groin in cases where it is absolutely necessary because these skin areas increase drug absorption, easily leading to side effects; Flucinar should be used with caution in patients with subcutaneous tissue atrophy, especially the elderly.

Pregnant women: Animal studies have shown that glucocorticosteroids are teratogenic at low doses, even for topical application. To date, there are no studies demonstrating harm to the fetus in humans. However, the use of flucinar in pregnant women should only be done when the benefits outweigh the risks. Absolutely do not use the drug in women who are pregnant in the first 3 months.
Lactating women: There are no studies demonstrating the excretion of the drug in breast milk. However, caution should be exercised when flucinar is used in lactating women.
Flucinar is indicated for the short-term treatment of acute or chronic conditions of glucocorticoid-responsive atopic dermatitis, seborrheic dermatitis, urticaria, hereditary dermatitis... To ensure effective treatment and avoid some unwanted side effects, patients need to strictly follow the instructions for use.
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