What is Lornine?

Lornine drug belongs to the group of anti-allergic drugs and is used in cases of hypersensitivity, indicated in the symptoms associated with allergic rhinitis such as sneezing, runny nose, and itchy nose, stinging eyes, ..
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Lornine is a tricyclic antihistamine containing Loratadine - a potent, long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity and no sedative effect on the nervous system. center. Lornine is also effective against itching and urticaria associated with histamine and other allergic skin disorders. However, Lornine has no protective or clinically helpful effects on severe histamine release such as anaphylaxis. Nasal and ocular signs and symptoms subside rapidly after oral administration.
Lornine has no sedative effect, in contrast to the sedative side effects of first generation antihistamines.
Lornine is rapidly absorbed after oral administration. Peak plasma concentrations of Lornine and its active metabolite (descarboethoxyloratadine) are 1.5 and 3.7 hours, respectively.
Drug distribution 97% bound to plasma proteins. Extensively metabolised in the liver for the first time by the cytochrome P450 microsomal enzyme system, Lornine is mainly converted to descarboethoxyloratadine, the pharmacologically active metabolite.
Approximately 80% of the total dose of Lornine is excreted in urine and feces equally, as metabolites, within 10 days.

Lornine is indicated in the following cases:
Allergic rhinitis: sneezing, runny nose, and itchy nose, itching and burning eyes. Chronic urticaria Other allergic skin disorders.

Lornine is contraindicated in the following cases:
Do not use Lornine for patients with hypersensitivity or allergy to one of the ingredients of the drug. Children under 2 years old. Objects to note before taking Lornine:
Elderly people, children under 15 years old; People with liver failure, kidney failure; People who are allergic to any substance in the composition of the drug; Myasthenia gravis ; Liver coma ; Stomach ulcers. Pregnant women need to be careful when taking Lornine because there is still a risk of reactions when used. Pregnant women need to carefully weigh the benefits and risks for mother and baby. Do not arbitrarily use the drug without carefully reading the instructions for use and instructions of the doctor to protect the mother and baby. Use caution when co-administering Lornine with alcohol, tobacco, alcoholic or fermented beverages. These agents can change the ingredients in the medicine.

Adults and children over 12 years: 1 tablet (10mg) once daily or 2 teaspoons (10ml) of Lornine syrup daily.
Children 2-12 years old:
Weight > 30 kg: 10ml (10mg = 2 teaspoons) Lornine syrup/day. Weight < 30 kg: 5ml (5mg =1 teaspoon) Lornine syrup/day.

Lornine did not cause clinically significant somnolence at a daily dose of 10 mg. Common adverse effects include:
Fatigue, headache; Drowsiness, dry mouth; Digestive disorders such as nausea, gastritis ; Allergic symptoms such as hives. Rare:
Hair loss; Anaphylaxis ; Liver dysfunction. Usually, the unwanted side effects when taking Lornine will go away when the drug is stopped. Inform your doctor or medical officer immediately if you suspect any side effects of Lornine.
Lornine drug belongs to the group of anti-allergic drugs and is used in cases of hypersensitivity, indicated in the symptoms associated with allergic rhinitis such as sneezing, runny nose, and itchy nose, burning eyes, .. .To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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