What is Trimebutin used for?

If you are suffering from digestive disorders such as irritable bowel syndrome, your doctor may recommend Trimebutine for this condition. You can continue reading the following article to better understand the prescription drug Trimebutin.

Trimebutine drug with active ingredient is Trimebutine, belongs to the group of antispasmodics.
You can find Trimebutine on the market with the following dosage forms and strengths:
Tablets, film-coated tablets: 100 mg, 200 mg; Form of solution for injection: 50 mg/ml; Oral solution form 4.8mg/ml x 250ml and 4.8mg/ml x 125ml.

Trimebutine can regulate gastrointestinal motility and antispasmodic by acting on the meissner plexus, auerbach - this is the local nervous system of the gastrointestinal mucosa that regulates the activity of the gastrointestinal tract. Digest.
A surprising thing about Trimebutine is that it has a two-way effect, both inhibiting and stimulating bowel movements.

Trimebutine is often used in the treatment of functional disorders of the gastrointestinal tract such as:
3.1. Trimebutine medicine to treat peptic ulcer disease
This is a disease in which the lining of the stomach and duodenum is degraded, the most common cause is Helicobacter pylori, stress and prolonged stress, and the use of antibiotics. non-steroidal inflammation, corticosteroids, derivatives of corticoid, alcohol, tobacco,...
Peptic ulcer may have different symptoms, depending on the location of the lesion and the age of the patient. Common is a burning, gnawing, pain that may or may not be related to meals.
3.2. Trimebutine is used to treat gastroesophageal reflux disease (GERD) Gastroesophageal reflux disease (GERD) is a condition in which the lower esophageal sphincter works less efficiently, causing gastric juices to move up from the stomach into the esophagus, causing a burning sensation. burning. If GERD is prolonged, it can lead to complications such as ulcerative colitis, esophageal carcinoma, and Barrett's esophagus.
The prominent symptom that can be encountered in the disease is heartburn, in some cases there is no reflux from the stomach to the mouth, in young children may vomit, anorexia, irritation, aspiration into the respiratory tract. When there are complications such as esophagitis, esophageal cancer may have painful swallowing, choking or bleeding in the esophagus,...
3.3. Trimebutine for irritable bowel syndrome (IBS)
Irritable bowel syndrome is discomfort, recurrent abdominal pain plus at least 2 of the following features: Relating to defecation, frequency of bowel movements, degree of stool hardness. The cause of irritable bowel syndrome is currently unknown.
In addition to gastrointestinal symptoms such as dull or intermittent abdominal pain, constipation or diarrhea, you may also experience symptoms such as fatigue, sleep disturbances, chronic headaches, muscle aches.
Diagnosis is based on clinical findings after excluding other common diseases through laboratory tests.
In addition, Trimebutine is also used to treat:
Abdominal bloating, constipation, diarrhea; After abdominal surgery to enhance the regenerative activity of the intestine, to prevent intestinal obstruction and paralytic ileus. As with any medication, Trimebutine should not be used if you are allergic to trimebutine or to any of its ingredients. When using the drug on pregnant and lactating women, children under 12 years old, doctors will always carefully consider the effects and consequences of the drug.

With Trimebutine tablets, you should take it before meals. With oral solution, you need to use some support items such as spoons, cups to be able to get the correct dose when using the medicine.
Doctors will prescribe a specific dose depending on your medical condition and response. Normally, for adults and children over 12 years old, the dose of Trimebutine is 300mg/day (1 tablet of 100mg/time x 3 times/day) and can sometimes be increased to 600mg/day.
The time you have to use the medicine is usually 3 days, but if you don't have any warning signs when using the medicine, the maximum time can be 7 days.
For children, the usual dose of Trimebutine is 5ml/5kg/day.

When you use Trimebutine together with some of the following drugs can cause effects such as:
When using Trimebutine with 1,2- Benzodiazepine will increase the CNS depressant effect of 1,2- Benzodiazepine up; When used together with drugs such as Acemetacin, Abacavir, Aceclofenac, Abame tapir, Acetaminophen will reduce the elimination rate, increase the concentration of Trimebutine in the blood; The therapeutic effect of Trimebutine is reduced when used with Acetazolamide; Combined with Acarbose, Acetohexamide causes hypoglycemia more than usual; Concomitant use with Acebutolol increases the possibility of bradycardia.

Trimebutine can be harmful to the body but is quite uncommon and you do not need to treat it.
The side effects of Trimebutine you may experience are:
On the gastrointestinal tract: Bad breath and dry mouth, diarrhea, indigestion, nausea, constipation, epigastric pain; For the central nervous system: Fatigue, drowsiness, dizziness, headache, feeling hot and cold; Drug allergy : Redness, itching, edema,... In addition, you may also have other problems such as menstrual disorders, pain in the breasts, chest tightness, tinnitus, mild deafness, anxiety, urinary retention, etc. increased liver enzymes.

Store the medicine in a dry place, the temperature is higher than 30 degrees Celsius and do not expose the medicine to direct sunlight. Trimebutine should be kept out of the reach of children and pets; Expired Trimebutine should not be used and must be destroyed according to the instructions of a qualified person. Do not throw the medicine into the toilet or water pipe; Take the correct dose of trimebutine prescribed by your doctor; Immediately notify the treating doctor if there are no signs of disease progression after a period of treatment; For pregnant women, there is no evidence that Trimebutine causes birth defects. However, it is still best to avoid using the drug during pregnancy, especially the first 3 months; Because the drug can cause drowsiness, fatigue, dizziness, nausea, so care should be taken if doing work with high concentration such as driving a car or operating machinery; You need to inform the treating doctor if you have a history of allergic reactions to drugs, excipients or to any drug or food...; When you miss a dose, you should skip it and take the next dose as prescribed by your doctor, avoiding the double dose; If you overdose and have unusual symptoms, you should immediately go to a medical facility. Alcohol, beer, tobacco, have certain interactions with Trimebutine , so use should be limited while taking the drug. In summary, the drug trimebutine can regulate gastrointestinal motility and antispasmodic. For safe and effective use, patients should consult and use the drug as prescribed by their doctor.