Uses of Sandostatin

Sandostatin drug has the main active ingredient is Octreotide acetate and other excipients in sufficient quantities. The drug is used in the treatment of tumors, cancer,...

1. What is Sandostatin?

The active ingredient Sandostatin is Octreotide. This is a type of synthetic compound derived from the active ingredient Somatostatin. Sandostatin drugs work by inhibiting the effects of certain hormones such as growth hormone. The active ingredient Sandostatin is stronger and lasts longer than the active ingredient Somatostatin.
Ingredients of 1 ampoule of Sandostatin:
Active ingredient Octreotide acetate, corresponding to Octreotide (a free peptide) 50mg, 100mg, 500mg. Lactic acid, mannitol. Composition of each ampoule of Sandostatin 0.1 mg/ml (multi-dose vial)
Active ingredient Octreotide acetate, corresponding to Octreotide (a free peptide) 200mg. Lactic acid, mannitol. Dosage forms of Sandostatin:
Solution for injection 50 mg/ml: 1 ml ampoules, 5 ampoules; Solution for injection 100 mg/ml: Tube of 1 ml, box of 5 ampoules; Solution for injection 500 mg/ml: Tube of 1 ml, box of 5 ampoules; Solution for injection 200 mg/ml: Multi-dose vial of 5 ml.

2. Effects of Sandostatin

Sandostatin is indicated for use in the following cases:
Normally, growth hormone works to control the growth of tissues, organs and bones. Therefore, Sandostatin drug has the effect of significantly reducing the signs and symptoms of acromegaly, including: Headache, joint pain, sweating in the extremities, numbness of hands and feet, fatigue. Control of markers and reduction of plasma growth hormone and IGF-1 levels in acromegaly in individuals who have responded inadequately to surgical intervention or radiation therapy. The drug Sandostatin is also indicated for the treatment of people with acromegaly who cannot be operated on, or in the waiting period until the effect of radiation therapy is achieved. Reducing signs and symptoms due to functional tumors of the gastrointestinal endocrine system (GEP): Carcinoid tumor with signs of carcinoid syndrome; VIPoma; Pancreatic islet alpha cell tumor; Gastrinomas/Zollinger-Ellison syndrome is often combined with treatment with proton pump inhibitors, or H2 antagonists; Pancreatic islet tumors in the management of hypoglycemia before surgery and in maintenance therapy; GRFoma. Sandostatin is not an anti-tumor therapy and does not cure these diseases. Prevention of complications after pancreatic surgery. Emergency treatment to stop bleeding and avoid recurrent bleeding due to gastroesophageal varices caused by cirrhosis. Sandostatin is used in combination with specific treatment, namely endoscopic sclerotherapy.

3. How to take Sandostatin

Inject subcutaneously, usually 2-3 times/day or as directed by the treating physician. Take Sandostatin at the same time of day to avoid forgetting. Depending on your health condition, the drug may be prescribed by your doctor for intravenous use. If your doctor directs you to self-inject Sandostatin subcutaneously, learn all instructions for use from your healthcare professional. Before use, visually inspect Sandostatin for particles or discoloration. Before injecting, medical staff will clean the injection site with antiseptic alcohol. At the same time, the nurse will also change the position of the injection site each time to avoid problem areas under the skin. The dose of treatment is based on your specific medical condition and response to treatment. Use Sandostatin regularly to get the most benefit from it. Tell your treating doctor if the condition does not improve or if it gets worse.

4. Therapeutic dose of Sandostatin

For acromegaly: Initial treatment dose is 0.05-0.1 mg subcutaneously every 8 hours, then titrate according to monthly assessment of GH levels and clinical symptoms. availability, and tolerability. For tumors of the endocrine system of the stomach - intestine - pancreas; Initial therapeutic dose of 0.05 mg, 1-2 times/day, subcutaneously, gradually increase dose to 0.2 mg and use 3 times/day depending on tolerability and response to treatment. At the same time, the doctor may prescribe a higher dose in some cases. The maintenance dose should be adjusted on a case-by-case basis. Complications after pancreatic surgery: Use Sandostatin 0.1 mg x 3 times daily subcutaneously for 7 consecutive days, starting on the day before surgery at least 1 hour before surgery. For bleeding due to esophageal varices: Use Sandostatin 0.025 mg/hour by continuous intravenous infusion for up to 5 days. Sandostatin can be diluted with physiological saline. Currently, there is limited experience with Sandostatin in children. Note: People who inject themselves under the skin must be specifically instructed by medical personnel. To reduce possible local reactions, the solution should be brought to room temperature prior to injection. In cases where multiple injections are required and within a short interval of time, avoid injecting drugs into the same site. For patients with hemorrhagic liver failure due to esophageal varices, Sandostatin is well tolerated at a therapeutic dose of 0.05 mg/hour by continuous intravenous infusion over a period of 5 days.

5. In case of overdose/forgotten dose

In case of drug overdose : An overdose of Sandostatin is not life-threatening. However, symptoms of overdose include irregular heartbeat, low blood pressure, cardiac arrest, decreased oxygen supply to the brain, severe stomach pain, jaundice, nausea, vomiting, loss of appetite, diarrhea, weakness, fatigue, lack of energy, weight loss, irritability and high blood levels of lactic acid. If you think you have overdosed on Sandostatin and experience such symptoms, call your doctor right away. In case of missed dose: Take a dose of Sandostatin as soon as you remember, then continue as usual. The effectiveness of treatment will not be significantly reduced if a dose is missed, but temporary reappearance of symptoms may occur until continued use of the drug. Do not inject a double dose of Sandostatin to make up for a missed dose.

6. Undesirable effects when treated with Sandostatin drug

To better understand the drug Sandostatin you must pay special attention to the side effects of the drug:
Causes digestive disorders such as vomiting, severe abdominal pain, pain in the upper abdomen and then spreading to the back. or cause severe constipation; diarrhea, flatulence; Heart arrhythmia occurs: slow or irregular heartbeat or fast heartbeat; High blood sugar therefore makes users feel thirsty, drink a lot, so they urinate a lot, fast hunger, dry mouth, fruity breath, drowsiness, dry skin, blurred vision and weight loss; Conversely, in the case of low blood sugar, you will experience headaches, sweating, confusion, irritability, hunger, dizziness, fast heartbeat, or a feeling of restlessness; Feeling tired, dry skin, joint pain or stiffness, muscle weakness, voice becomes hoarse, more sensitive to cold temperatures, weight gain. These effects are caused by an overactive thyroid gland. Pain at the injection site.

7. Sandostatin drug interactions

Tell your treating doctor or pharmacist if you have recently taken, are taking or may be taking any other medicines. Some drugs can interact with Sandostatin if used in combination with drugs such as Cimetidine, Cyclosporin, Bromocriptine, Quinidine and Terfenadine. You are taking medications to control your blood pressure including beta blockers or calcium blockers. If you have diabetes, your doctor may need to adjust the dose of insulin you are taking.

8. Some notes when using Sandostatin drug

8.1. Notes and cautions when using Sandostatin medicine
Inform your treating doctor before using Sandostatin:
If you have gallstones or have had before; Tell your doctor because prolonged use of Sandostatin can lead to the formation of gallstones. Blood sugar levels are too high or too low when using Sandostatin, which is used to treat bleeding caused by esophageal varices. Get tested and checked: If you've been on Sandostatin for a long time, your doctor will likely check your thyroid function periodically. In addition, your doctor will check your liver function and vitamin B12 periodically. 8.2. Using the drug with other special subjects
For those who drive and use machines: Sandostatin has no or little effect on the ability to drive and use machines. However, some of the side effects you may experience while using Sandostatin, such as headache and fatigue, may decrease your ability to drive and operate machinery safely.
For women who are pregnant or breastfeeding
If you are pregnant or breastfeeding or you think you may be pregnant or are planning to have a baby, you need to talk to your doctor doctor for advice before using this medicine. Sandostatin should be used during pregnancy only if clearly needed after the benefits and risks have been weighed by your doctor. Women of childbearing age should use effective methods of contraception during treatment with Sandostatin. Do not breast-feed while using Sandostatin. Above are the uses and doses of Sandostatin. Patients should carefully read the instructions for use, consult a doctor before use to ensure safety and maximize the effectiveness of treatment.

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