Fructose metabolism disorder

The article was consulted with Specialist Doctor I Vo Thi Thuy Trang - Department of Medical Examination & Internal Medicine - Vinmec Da Nang International General Hospital.

Fructose metabolism disorder is one of many disorders of carbohydrate metabolism. When it comes to fructose metabolism, the symptoms will vary from person to person. The treatment of this disorder is mainly based on the cause of the disease and depends on the severity of the reaction.

Fructose is a monosaccharide found in high concentrations in honey or fruits. Fructose is a component of sucrose and sorbitol. Fructose metabolism is one of many disorders of carbohydrate metabolism. When it comes to fructose metabolism, the symptoms will vary from person to person. Some common symptoms in fructose metabolism disorder include:
The patient has stomach cramps, nausea and vomiting; There may be a change in the frequency of defecation, defecation several times a day; Abdominal discomfort, bloating; Occurrence of headaches and migraines; Nasal congestion, wheezing are also one of the signs of fructose metabolism disorder. This symptom is often confused with respiratory diseases; Fructose metabolism disorders can lead to itchy rashes such as eczema or swollen skin; Some people with fructose metabolism disorder have a tingling or itching sensation in the mouth or may cause swelling of the lips, tongue, face, or other parts of the body; In severe cases, fainting, shortness of breath, rapid heart rate, anaphylaxis or life-threatening reactions to food exposure or consumption can occur.

There are many causes of this metabolic disorder. Fructose 1-phosphate aldolase (aldolase B) deficiency causes are as follows:
Fructose 1-phosphate aldolase (aldolase B) deficiency causes a clinical syndrome of hereditary fructose metabolism disorder. . When young children eat fructose; Fructose 1-phosphate will then accumulate and lead to a variety of symptoms such as hypoglycemia, abdominal pain, profuse sweating, nausea and vomiting, lethargy, convulsions, coma, etc. This substance can lead to liver diseases such as cirrhosis, renal tubular acidosis, and loss of phosphate and glucose in the urine. Fructokinase deficiency: A fructokinase deficiency results in benign elevations of fructose in the blood and urine. Fructokinase deficiency is asymptomatic and diagnosed incidentally through urinalysis. Fructose-1,6-biphosphatase deficiency: A deficiency of fructose-1,6-biphosphatase affects gluconeogenesis and results in hypoglycemia, ketosis, and acidosis. This condition is extremely dangerous, it can be fatal in babies.

The treatment of fructose metabolism disorders is mainly based on the cause of the disease and depends on the severity of the reaction. Specific treatments are as follows:
For Fructose 1-phosphate aldolase deficiency causes: The short-term treatment of fructose 1-phosphate aldolase deficiency is glucose in hypoglycemia. The long-term treatment is to eliminate fructose, sorbitol as well as sucrose. The treatment of this cause has a good prognosis as well as treatment. For the cause of fructose-1,6-biphosphatase deficiency: The acute treatment for fructose-1,6-biphosphatase deficiency is oral or intravenous glucose. In addition, people with impaired fructose metabolism can manage the condition by changing their diet, avoiding or significantly reducing their sugar intake. At the same time, the patient should keep a record of the foods he eats to track reactions.

Patients need to go to a reputable hospital to conduct examination and treatment as soon as there are signs of fructose metabolism disorder. Currently, Vinmec International General Hospital is one of the prestigious hospitals in the country, trusted by a large number of patients for medical examination and treatment. Not only the physical system, modern equipment: 6 ultrasound rooms, 4 DR X-ray rooms (1 full-axis machine, 1 light machine, 1 general machine and 1 mammography machine) , 2 DR portable X-ray machines, 2 multi-row computer tomography rooms with receivers (1 machine 128 rows and 1 machine 16 rows), 2 rooms for magnetic resonance imaging (1 machine 3 Tesla and 1 machine 1.5 Tesla), 1 room for 2 level interventional angiography and 1 room for bone mineral density.... Vinmec is also the place to gather a team of experienced doctors and nurses who will greatly assist in the diagnosis and detection. early signs of abnormality of the patient's body. In particular, with the space designed according to hotel standards, Vinmec ensures to bring the patient the most comfort, friendliness and peace of mind.