Be careful with drugs that cause Serotonin syndrome

Complications of severe Serotonin syndrome can cause metabolic acidosis, rhabdomyolysis, acute kidney injury, convulsions, disseminated intravascular coagulation or death in patients.
The main cause of Serotonin syndrome is medication. The drugs that cause Serotonin syndrome are:
Antidepressants: Includes selective Serotonin reuptake inhibitors, Serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, and tricyclic antidepressants. Monoamine oxidase inhibitor group... Triptan drug group to treat migraine: Some drugs like Almotriptan, Naratriptan, Sumatriptan,... are drugs that cause serotonin syndrome. Antiemetic drugs Metoclopramide Hallucinogens such as Amphetamine, cocaine... Opioid analgesics such as Hydrocodone, Heroin Cough medicines such as Dextromethorphan

The main manifestations of the syndrome of hyperserotonin are: Neuromuscular disorders (accounts for 50%), mental status changes (accounts for about 40% of patients) and increased autonomic nervous system activity (accounts for more than approx. 40% of patients). Symptoms of psychosis, altered mental status, and increased autonomic nervous system activity usually occur within minutes to hours of dosing, but do not always occur in patients.
Symptoms can be mild or severe, endangering the patient's life. Severe cases can lead to complications such as convulsions, myoglobinuria, renal failure, acute respiratory failure, respiratory failure, metabolic acidosis, disseminated intravascular coagulation, coma and death....
Association Hyperserotoninemia is difficult to distinguish from other medical conditions such as neuroleptic malignant syndrome, malignant fever, and anticholinergic toxicity. Therefore, in order to accurately diagnose the disease, in addition to the clinical symptoms, it is necessary to do more complete blood tests, comprehensive metabolic panel tests, computed tomography scans, electrocardiograms, urine tests, and X-rays. optical.

The treatment of Serotonin syndrome is prioritizing discontinuation of the suspected drug and supportive care. In less severe cases, cyproheptadine can be used until symptoms subside. In severe cases, drugs such as benzodiazepines or 5-hydroxytryptamine 2 receptor antagonists can be used. can cause this syndrome to prevent during treatment. Also, to reduce your risk of developing Serotonin syndrome, tell your doctor about all medications and dietary supplements you are currently taking.
Using drugs exactly as prescribed and safely is an effective way to prevent serotonin syndrome, so each person needs to be aware of the use of drugs according to the doctor's instructions, do not arbitrarily buy drugs to treat and treat serotonin syndrome. combine them together. If you are worried about how to use medicine properly, you can go to the Pharmacy Department - Vinmec International General Hospital with a system of modern facilities, medical equipment, and the same team. With a team of experts, doctors and pharmacists with many years of experience in medical examination, consultation and treatment, patients can rest assured when listening to advice on drug use at the Hospital.