Quantification of anti-Cardiolipin IgG

The article was professionally consulted with Master, Doctor Pham Thi Thuy Nhung - Head of Laboratory Department - Laboratory Department - Vinmec Hai Phong International General Hospital.

Quantification of anti-Cardiolipin IgG is used to evaluate in some pathologies of antiphospholipid syndrome such as thrombocytopenia, myocardial infarction, repeated miscarriage, arterial and venous thrombosis..
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Cardiolipin is an important component of the mitochondrial inner membrane, essential for the optimal function of many enzymes involved in mitochondrial energy metabolism.
There are two types of anti-cardiolipin antibodies, IgM and IgG, where anti-Cardiolipin IgG is expressed in units of GPL-U/mL of serum or plasma. The limit of negative anti-IgG antibodies is <9.5 GPL -U/mL
Anti-Cardiolipin IgG antibodies detected in antiphospholipid syndrome include: Multiple miscarriages, thrombocytopenia, myocardial infarction , systemic lupus erythematosus, arterial and venous thrombosis,... Therefore, a quantitative test of anti-Cardiolipin IgG antibodies in cases of suspected patient with antiphospholipid syndrome should be performed.

Measurement of anticardiolipin antibodies is a type of blood test, usually done when blood clotting is abnormal. The test is used to determine the cause of conditions such as:
Blood clots forming inside a blood vessel for no apparent reason Repeated miscarriage Prolonged clotting time. However, test results may be affected by patients who have had syphilis, or AIDS, inflammation, cancer, and autoimmune diseases. Or patients who are taking penicillin, quinidine, hydralazine, phenytoin, chlorpromazine,...

Clinical significance of anticardiolipin IgG antibody titer:
Autoantibodies directed against phospholipids, especially anticardiolipin antibodies are frequently present in venous and arterial thrombosis and thrombocytopenia and thrombocytopenia. bridge . Anti-cardiolipin autoantibodies are also present in many autoimmune diseases such as: systemic lupus erythematosus, recurrent miscarriage, hypertension during pregnancy, preeclampsia, and gestational diabetes. Anti-cardiolipin IgG antibodies are also detected in neurological disorders such as cerebral circulatory insufficiency, cerebral ischemia, cerebral infarction and cerebral hemorrhage. Anticardiolipin IgG antibodies have been detected in patients with thrombosis, thrombocytopenia, abortion, and in some patients with neurological disorders. Anticardiolipin IgG antibodies are seen in advanced stages of autoimmune disorders. If an anticardiolipin IgG quantitation test is performed and anticardiolipin antibodies are detected in the blood, the test should be repeated approximately 6 weeks later, to determine if these antibodies are present or have persisted. long time ago.

In summary, quantification of anticardiolipin IgG is intended to determine the cause when abnormalities in coagulation are present. In addition, quantification of anticardiolipin IgG antibodies is also used to evaluate in a number of diseases such as multiple miscarriages, thrombocytopenia, thrombosis, neurological disorders or in the course of autoimmune disorders.