The role of the AMH test in assessing fertility in people with premature ovarian failure

The article was professionally consulted by Specialist Doctor II Pham Thi Tuyet Mai - Obstetrician and Gynecologist - Department of Obstetrics and Gynecology, Vinmec Hai Phong International General Hospital

The AMH test is the most accurate test for evaluating ovarian fertility. This test plays a very important role in assessing fertility in people with premature ovarian failure.

AMH (Anti-mullerian Hormone) is secreted directly by the granulosa cells of ovarian follicles and is directly related to the number of primordial follicles in the ovary. The amount of AMH indicates the number of immature follicles currently in the ovary, also known as the ovarian reserve. Better ovarian reserve means higher fertility of the ovaries and vice versa.
AMH levels do not change significantly during the menstrual cycle and decrease with age. In healthy women under 38 years of age, normal AMH levels range from 2.0 to 6.8 ng/ml (14.28 to 48.55 pmol/L). In addition, AMH concentrations above these values ​​were also observed in women with PCOS.
AMH concentration will be constant, does not change with the menstrual cycle, so it can be done on any day of the menstrual cycle. This is the advantage of the AMH test over the previous FSH test. Therefore, making ovarian fertility testing becomes much more convenient for patients. Previously, tests to evaluate ovarian function (FSH, LH, E2) had to be performed at the beginning of the menstrual cycle (days 2-4).

AMH testing has only just been rolled out in the world. This test plays an important role in determining ovarian fertility, especially in patients with premature ovarian failure:
AMH reflects the number of eggs produced in a woman's monthly cycle. The level of AMH in a woman's blood is an indicator of ovarian reserve and is useful in assessing fertility, especially in patients with impaired ovarian reserve; This test plays a very important role in the diagnosis and treatment of infertility, especially before performing ovarian stimulation and in vitro fertilization. Women with low AMH levels often do not respond well to fertility drugs and must use larger amounts of the drug to successfully induce ovulation. In contrast, when AMH is high, the patient responds well to fertility drugs, ovulates a lot and when there are many eggs, IVF has a higher chance of success; Repeated AMH testing over time can help assess the number of oocytes remaining in the ovaries and the progression of ovarian failure. As a result, this test can be used to diagnose the fertility of patients with ovarian failure who want to have children, and to predict the time needed for treatment intervention;

AMH concentration is often not an assessment of egg quality, but when prognosticating many eggs, we have a higher ability to select embryos of good quality for transfer to the uterus and have a higher chance of having residual embryos cold is also more; Evaluation of AMH levels is also useful in women who wish to delay childbirth and plan for future pregnancies. Couples with fertility problems can come to Vinmec IVF Reproductive Center - the leading prestigious address for reproductive support in general and infertility treatment in particular. The Center applies the most advanced assisted reproductive methods in the world, which are:
Intrauterine insemination (IUI); Classic in vitro fertilization (IVF); Intracytoplasmic sperm injection (ICSI); Support embryo escape membrane; Blastocyst transfer - day 5 embryo transfer; Cryopreservation of embryos, ovules and sperm; Donating eggs, sperm and embryos; Male infertility techniques: Sperm aspiration from the epididymis (PESA), Microsurgical sperm aspiration procedure from the epididymis (MESA),... Besides, IVF Vinmec brings together a team of doctors who are: leading experts in the field of infertility treatment, such as Dr., Doctor To Minh Huong - Formerly Deputy Director and Head of Department of Reproductive Support, Hanoi Obstetrics and Gynecology Hospital; Master, Doctor Le Thi Phuong Lan - Former Deputy Director of the National Center for Reproductive Support; Dr. Jean Clément Sage - The leading expert in IVF in France, along with many other qualified and experienced doctors.