Be careful when treating bone cancer with male medicine

Bone cancer is the most common type in children and adolescents. In addition to standard treatments, such as surgery, chemotherapy, and radiation, patients sometimes find hope in TCM for bone cancer. Today, the scientific community is still researching the treatment of bone cancer with herbal medicine, but the effectiveness is still limited and there are many considerations when using it.

Medicinal plants have been used as a traditional treatment for a variety of ailments across all ages. They also play an important role as an effective source of anti-cancer agents. More than 60% of the anticancer agents used today are derived from nature such as plants, marine life and microorganisms.
Plant-based anticancer drugs currently in clinical use can be classified into 4 main groups of compounds: Vinca (or Catharanthus) alkaloids, epipodophyllotoxins, taxanes and camptothecins. The search for plant-based anticancer agents began in the 1950s with the discovery and development of vinca alkaloids, the isolation of cytotoxic podophyllotoxins. The vinca alkaloids vinblastine and vincristine were isolated from the Madagascar periwinkle (Catharanthus roseus or Vinca rosea). These alkaloids and their semi-synthetic derivatives can block the transitional mitosis that induces cell death. Since then, this plant has been used in the treatment of leukemia, lymphoma, Kaposi's sarcoma, testicular cancer, breast and lung cancer for over 40 years.
Similarly, podophyllotoxins isolated from the resin of the plant Podophylum peltatum have also been shown to inhibit mitosis in metabolism by inhibiting the cell death-induced tubulin polymerization phase. However, the use of this plant was not successful because of their serious side effects.
However, further studies on semi-synthetic podophyllotoxin derivatives such as etoposide and teniposide showed the ability to inhibit the catalytic activity of DNA topoisomerase II causing irreversible breaks in DNA and process self-consumption. Based on this efficacy, etoposide and teniposide are used in the treatment of lymphomas, as well as acute leukemia, small cell lung, testicular, ovarian, and bladder cancers.
Over time, more extensive plant collection programs are conducted around the world, collecting thousands of species of plants and marine life to extract and screen for anti-tumor properties. So far, only 1% of the ∼500. 000 plant species worldwide are phytochemically investigated. Therefore, it is likely that many new bioactive compounds are waiting to be discovered and developed for the treatment of pathologies such as bone metastases. Accordingly, the problem of treating bone cancer with male medicine is an area that still needs to be explored.

Bone cancer is the most common bone malignancy and a major cause of cancer death, especially in children and adolescents. Bone malignancies have an incidence of about 3.5 cases per 1 million people worldwide. The combination of surgery and adjuvant chemotherapy is currently the standard treatment for these patients.
Of these, first-line chemotherapy using Methotrexate, Cisplatin, Doxorubicin or Ifosfamide is used for patients with bone cancer. At the same time, the etoposide component, a plant alkaloid, is also used to treat metastatic disease.
Despite significant improvement in diagnosis and treatment methods, including using Traditional Chinese Medicine to treat bone cancer, about 65% of patients with the disease still do not achieve good results. The 5-year survival rate of localized cancer patients remains at 50%. Therefore, new more effective agents should be investigated to improve treatment outcomes in bone cancer patients. Natural bioactive compounds are a unique, step-by-step class of agents that have shown many promising effects, with few side effects, and at low cost that are being studied to improve the effectiveness of tumor treatment. skeletal.
Thus, the method of treating bone cancer by Traditional Medicine with natural biologically active compounds, extracts and derivatives has been proven to have a versatile chemotherapeutic effect, with unique properties. different pharmacological, structural and molecular properties.

As shown, several compounds isolated from natural plant sources have shown promising effects against bone cancer while the use of conventional chemotherapy can cause many adverse effects. side use. On the other hand, as resistance to chemotherapy progresses, conventional drugs for the treatment of bone cancer become less and less effective. Therefore, it is extremely important to find newer bioactive compounds from nature to control the development or progression of different types of cancer in general and cancer. bones in particular. Among them, medicinal plants and natural products are rich sources of a wide range of bioactive compounds, with proven anticancer, immunomodulatory and antioxidant activities.
However, further studies are also needed to uncover powerful anti-cancer agents, because there are many natural products or their extracts that are still undiscovered and may contain chemical compounds. undetected substances interacting with recently discovered signaling pathways. The goal of molecular management of cancer pathophysiology is not merely to kill malignant cells but also to control the cancer phenotype.
It is also important to take into account the history of traditional medicine use for bone cancer that stretches back thousands of years, despite the lack of solid laboratory evidence for the use of some ingredients. However, natural products tend to have relatively low systemic toxicity and moreover can often reduce toxicity caused by common cytotoxic drugs. In this context, evidence-based medicine requires the conduct of controlled clinical trials, even on a series of herbal treatments for bone cancer that are generally accepted as safe. These results should therefore provide the basis for the hope that osteosarcoma is a cancer that will respond well to the addition of natural products to standard chemotherapy.
Therefore, in the process of choosing drugs for patients, doctors always have to base on experimental evidence of safety and effectiveness, suitable for each situation. Absolutely do not use ingredients of unknown origin or without convincing evidence in the treatment. On the side of the patient, although the treatment of bone cancer by traditional medicine has gradually persuaded the modern medical world, the radical attitude of promotion also needs to be abolished. Right from the time of diagnosis and treatment plan, patients need to follow the doctor's regimen to control and destroy malignant cells, only combine Traditional Medicine to treat bone cancer when indicated, and avoid wasteful and especially suffering from side effects caused by improper treatment.
Current therapies for the treatment of bone cancer, especially in the metastatic stage, can help improve the disease but cannot cure or promote the regression of metastatic tissues that have formed. Therefore, more effective therapies are needed. With medicinal plants that have been used for centuries to treat various cancers and many modern medicines have been developed from them, TCM for bone cancer is gradually gaining recognition. Therefore, the discovery of herbal cures for bone cancer with natural compounds that are effective against drug-resistant tumors is an important strategy to improve cancer treatment. However, patients do not arbitrarily cure bone cancer with Traditional Medicine, but must follow the doctor's instructions, be suitable for each stage, limit side effects to have a synergistic effect with chemotherapy measures. optimal radiation therapy.