Uses of Acectum

Acectum is a product of Karnataka Antibiotics & Pharma., Ltd, which combines a broad-spectrum antibiotic, Piperacillin, and a beta-lactamase inhibitor, Tazobactam. So what does Acectum do?

Acectum has ingredients in 1 vial including 4g Piperacillin antibiotic and 0.5g Tazobactam
Acectum is a product of Karnataka Antibiotics & Pharma., Ltd (India), made in dry powder for injection and packaged Pack 1 vial per box.

What does Acectum do? Piperacillin is a semisynthetic penicillin antibiotic with a broad spectrum of activity against a wide range of aerobic and anaerobic, Gram-positive and Gram-negative bacteria. Piperacillin's mechanism of action is inhibition of bacterial cell wall and wall synthesis.
Tazobactam has a chemical structure as a Triazolyl methyl penicillanic acid sulfone, which has strong inhibitory ability on many beta-lactamase enzymes, especially plasmid-mediated enzymes with high resistance to Penicillin and Cephalosporins (especially third generation cephalosporins). The presence of Tazobactam in Acectum enhances the antibacterial spectrum of Piperacillin, including beta-lactamase-producing strains that are already resistant to other beta-lactam antibiotics.
Acectum is a combination of a broad-spectrum antibiotic with a beta-lactamase inhibitor, so it is particularly useful when indicated for the treatment of mixed infections or for containment therapy before resistance results are available. biograph, because it has a very broad spectrum of activity.

Indications of Acectum in the following cases:
Systemic or local infections confirmed or suspected due to susceptible strains of microorganisms, including lower respiratory tract infections, complicated urinary tract infections, intra-abdominal infections, soft tissue skin infections, sepsis, obstetric and gynecological infections or polymicrobial infections; Piperacillin/Tazobactam is synergistic with Aminoglycosides against some strains of blue pus bacillus (Pseudomonas aeruginosa). Therefore, the combination of Acectum with Aminoglycoside is highly effective, especially in patients with reduced resistance. Acectum is contraindicated in patients with a history of allergy to Piperacillin and/or other Cephalosporins, or to beta-lactamase inhibitors such as Tazobactam.

Dosage and use of Acetum refer to the following:
Dosage in adults and children over 12 years old: 1 vial of Acectum intravenously every 8 hours. The total daily dose of Piperacillin/Tazobactam may vary from 2.25 to 4.5 g every 6 to 8 hours.
Dosage of Acectum for children under 12 years old: There are not enough data on the use of this drug for this population.
Renal impairment: Acectum dose must be adjusted according to creatinine clearance:
Creatinine clearance 20-80ml/min: 1 vial of Acectum, administered every 8 hours; Creatinine clearance less than 20 ml/min: 1 vial of Acectum administered every 12 hours; Patients on hemodialysis, the maximum total daily dose is 8g Piperacillin/1g Tazobactam corresponding to 2 vials of Acectum; A 4-hour dialysis cycle can remove 30-50% of Piperacillin, so after each dialysis cycle, an additional 1⁄2 vials of Acectum should be administered to the patient. Duration of treatment with Cefactum: Patients should be treated with Acectum until at least 48 hours after fever has disappeared or clinical symptoms have improved.
How to use Acectum:
Intravenous: Each vial of Acectum is mixed with 20ml of sterile distilled water or 0.9% NaCl, then injected slowly for 3-5 minutes; Intravenous infusion: Each vial of Acectum is mixed with 20ml of sterile distilled water or 0.9% NaCl, then further diluted with at least 50ml of 0.9% NaCl and infused intravenously over 20-30 minutes. Acectum overdose and management:
Acectum has no specific antidote and there is also limited experience due to drug overdose. However, in the case of acute Acectum poisoning, all medical measures are indicated in the same way as Piperacillin poisoning. At the same time, Piperacillin with too high serum concentrations can be removed by hemodialysis; Doses of 24 g or more of Piperacillin per day have been indicated in humans without adverse effects observed. In case of motor agitation or convulsions, the patient may be prescribed anticonvulsant drugs; In case of overdose of Acectum and prolonged severe diarrhea, the possibility of pseudomembranous colitis should be considered. Therefore, Acectum must be discontinued in such cases and appropriate therapy initiated, while the use of drugs that inhibit intestinal motility is contraindicated.

Acectum topical side effects have been reported as possible or possibly related to Piperacillin/Tazobactam treatment, including phlebitis (0.2%) and thrombophlebitis (0.3%).
The most common clinical systemic adverse reactions of Acectum were diarrhea (3.8%), rash (0.6%), erythema (0.5%), pruritus (0.2%), vomiting (0.4%), nausea (0.3%), allergic reactions (0.4%), urticaria (0.2%), and superinfections with non-susceptible organisms (0.2%).
Adverse laboratory changes reported in studies but not related to Acectum were transient decrease in white blood cell count, eosinophilia, thrombocytopenic purpura, thrombocytopenia, Coombs positive test, hypokalemia, transient elevation of liver enzymes (SGOT, SGPT, alkaline phosphatase) and serum bilirubin.

Possible drug interactions of Acectum during use are as follows:
Concomitant administration of Probenecid with Acectum increases the half-life and clearance rates of both Piperacillin and Tazobactam, but peak plasma concentrations do not affected. There was no drug interaction between Acectum with Vancomycin or with Tobramycin. When combining Acectum with another drug, do not mix in the same vial or inject at the same time due to physical incompatibility. When Acectum is co-administered with high doses of heparin, oral anticoagulants, or drugs affecting the coagulation system and/or platelet function, the patient's coagulation tests should be performed regularly and monitored. more careful.

Use Acectum with caution in the following cases:
Before starting treatment with Acectum, your doctor must carefully understand the history of allergy to Penicillin antibiotics, Cephalosporins or any other allergic conditions. . If an allergic reaction occurs during treatment with Acectum, the patient must immediately discontinue the drug. Although Piperacillin/Tazobactam has low toxicity, which is typical of penicillin antibiotics, patients should still periodically check the function of organs such as kidney, liver, hematopoietic system during long-term treatment with Acectum. Bleeding manifestations have occurred in some patients treated with beta-lactam antibiotics, including Acectum. These reactions sometimes occur in conjunction with laboratory abnormalities of coagulation such as clotting time, platelet aggregation, and prothrombin time and are more common in patients with renal impairment. If hemorrhagic manifestations occur as a result of antibiotic therapy, Acectum should be discontinued and appropriate therapy instituted. Similar to other antibiotics, when using Acectum, always pay attention to the possibility of emergence of resistant strains of bacteria, especially during prolonged treatment. As with other penicillins, patients may experience neuromuscular excitability or convulsions if higher than recommended intravenous doses of Acectum are administered. During Acectum administration, the patient should be periodically monitored for ionization if there is a low potassium reserve, and the hypokalaemic effect should always be kept in mind in patients with extremely low potassium stores and concomitant cytotoxic drugs. or diuretics. Taking high-dose, short-term antibiotics to treat gonorrhea may mask or delay the onset of symptoms of syphilis. Therefore, patients with gonorrhea should be tested for syphilis prior to treatment with Acectum. There are no adequate studies on the use of Acectum during pregnancy and lactation. Piperacillin/tazobactam was shown to have no effect on fertility and no teratogenicity in laboratory rats. However, pending full experimental results, pregnant or lactating patients should only use Acectum when the benefits outweigh the risks to both the patient and the fetus. Vials containing Acectum lyophilized powder can be stored at controlled room temperature (15-25°C) for up to 3 years. When properly mixed, Acectum remains stable for 24 hours, if stored in the refrigerator (temperature 2-8°C). Note Acectum must not be mixed with other drugs in the same syringe or the same bottle of infusion. Acectum is a combination of a broad-spectrum antibiotic with a beta-lactamase inhibitor. The drug is prescribed by doctors in some infectious diseases and is used intravenously. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.