Uses of Ametifen codeine forte

Ametifen Codein Forte is a combination pain reliever. It is used to relieve symptoms of moderate to severe pain. However, patients should only use the drug for a short time, because the drug has the risk of addiction if prolonged or used in high doses.

What is Ametifen codeine forte? Ametifen codeine Forte drug has the main ingredients Acetaminophen 500 mg and Codeine phosphate 30 mg, packaged in the form of long film-coated tablets.
Paracetamol is a non-steroidal antipyretic analgesic. Paracetamol (acetaminophen or N - acetyl - p - aminophenol) is an active metabolite of phenacetin, which is an effective analgesic and antipyretic that can replace aspirin, with fewer side effects. However, unlike aspirin, paracetamol has no effect on inflammation and does not have an antiplatelet effect.
Codeine is an opioid pain reliever. Used to relieve pain due to weak binding to Opioid receptors and the main effect is due to the formation of morphine after entering the body. Studies have shown that the drug is effective when combined with paracetamol in the treatment of acute pain.

2.1. Indications With a combination of acetaminophen and codeine used in the treatment of moderate to severe pain, such as: Cancer pain, bone pain, Severe headache, body aches, pain muscle pain, neuralgia, toothache and backache, etc. Pain after surgery. 2.2.Contraindications Ametifen codeine Forte should not be used in the following cases:
Patients with a history of hypersensitivity or allergy to any ingredient of the drug. Patients with severe hepatic or renal impairment. Patient is alcoholic. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with respiratory failure, many times anemia, heart and lung disease. Pregnant and lactating women. Not recommended for children under 12 years old. Children under 18 years of age who have just had their tonsils removed or after a curettage of V.A. can cause serious reactions and possibly death.

How to use: Ametifen codeine forte is used orally, patients can take the drug at any time, because the drug does not affect food. The patient should take the medication when pain occurs and should be spaced at least 4 to 6 hours apart. If stomach irritation should be taken after eating.
Dosage:
Adults: Take 1 to 2 tablets each time, 3-4 times a day. The doses should be at least 4 hours apart and not more than 8 times. Children from 12 to 18 years old: 1 tablet each time, 3-4 times a day. Takes at least 6 hours apart. The maximum dose should not exceed 8 tablets. Children under 12 years: Not recommended, due to risk of opioid toxicity. Overdose:
For paracetamol: Paracetamol toxicity can be caused by a single toxic dose, or by repeated ingestion of large doses of paracetamol (eg, 7.5 - 10g daily, for 1-2 days) or long-term medication. Acute liver necrosis is dose-dependent and can be fatal. Manifestations include nausea, vomiting, abdominal pain, methemoglobinemia, leading to cyanosis of the skin. In severe poisoning, may initially cause central nervous system stimulation, agitation and delirium. This may be followed by central nervous system depression such as stupor, hypothermia, fatigue, rapid, shallow breathing; rapid pulse. Patients need to be treated quickly in the first 36-48 hours. Codeine: Overdose can cause respiratory depression, drowsiness or coma. More severe can cause cardiac arrest and death. Patients need to be taken to the hospital and treated quickly.

When taking the drug you may experience the following undesirable effects:
Common effects: Nausea, vomiting, constipation, thirst, little urine, urinary retention, drowsiness, nervousness, dizziness, orthostatic hypotension. Uncommon: Allergic reactions, leukopenia, anemia, respiratory failure, restlessness, pancytopenia, kidney disease, bile duct spasm, cyanosis of the skin. Rare: Anaphylaxis, visual disturbances, hallucinations, disorientation, convulsions, withdrawal syndrome. In addition, Ametifen codeine forte drug can also cause serious skin reactions such as Stevens-Johnson syndrome, toxic skin necrosis syndrome, acute generalized exanthematous syndrome. Patients may experience other side effects while taking the drug. Accordingly, please inform your doctor of any unwanted effects that you experience when using the drug.

This is a prescription drug that is used according to the doctor's prescription, the patient should not self-medicate to treat mild pain, but should only use it if it does not respond to ordinary pain relievers. When taking the drug can increase head damage and cause increased intracranial pressure. Adverse drug reactions may mask the clinical course of patients with head injury, and should therefore be used with caution. Administration of Ametifen codeine forte may also obscure the diagnosis or mask the clinical course of patients with acute abdominal diseases. Ametifen codeine forte should be used with caution in elderly or frail patients, patients with mild to moderate impairment of liver or kidney function, bronchial asthma, history of drug addiction, hypothyroidism, Addison's patients. and people with prostate enlargement or urethral obstruction. Concomitant use with other narcotic analgesics, antipsychotics, tranquilizers, or other CNS depressants, alcohol. When co-administration is required, the dose of one or both drugs should be reduced. Accordingly, patients should also not use this drug with other drugs containing acetaminophen or non-steroidal anti-inflammatory pain relievers. Prolonged use and high doses of acetaminophen can cause liver cell damage. As for codeine, if used for a long time, it can cause addiction. Therefore, you need to take the medicine exactly as prescribed and do not arbitrarily take it for a long time. Use caution when driving vehicles and operating machinery, because taking this medicine can cause drowsiness. Drug interactions:
Drugs that neutralize stomach acid can slow and prolong the absorption of acetaminophen when taken orally. The activity of the drug can be affected when taken with different drugs such as barbiturates, antidepressants, carbamazepine and phenytoin. Concomitant use of this drug with other opiate derivatives (found in cough medicines, other analgesics) may increase the risk of respiratory depression. Interactions with anticonvulsants, isoniazid, and quinidine may lead to loss of effect of codeine. The drug may reduce the metabolism of cyclosporin and some other drugs because codeine inhibits cytochrome P450 enzymes. Hopefully, with the above information, you know what Ametifen codein forte has and what to pay attention to when using. If you have any questions, please consult your doctor or pharmacist for advice.
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