Uses of Avepzon

Avepzon is indicated for the treatment of infections caused by susceptible strains of bacteria. Let's learn about Avepzon medicine about its uses and notes when using it to ensure its safety and effectiveness for patients in the article below.

Avepzon contains the main ingredient Cefoperazone sodium 0.5g, Sulbactam sodium 0.5g and other excipients just enough for 1 tablet provided by the manufacturer. The dosage form of the drug is a powder for injection, the packaging is in the form of a box of 1 vial and a tube of 5ml distilled water. Cefoperazone belongs to the group of semi-synthetic antibiotics of the 3rd generation Cephalosporin group, which has a bactericidal effect by inhibiting the synthesis of the growing and dividing bacterial cell wall. Cefoperazone is an parenteral antibiotic with antibacterial activity similar to ceftazidime. Cefoperazone is very stable against beta - lactamases formed in most gram-negative bacteria, including penicillinase-producing strains of N. Gonorrhoeae and most strains of Enterobacter, Citrobacter, Proteus...). Cefoperazone's ability to kill Enterobacteriaceae is weaker than that of other 3rd generation Cephalosporins. Cefoperazone is usually active against bacteria resistant to other beta-lactamase antibiotics.

Avepzon is indicated for the treatment of infectious diseases caused by the following susceptible strains of bacteria:
Upper and lower respiratory tract infections such as pharyngitis, bronchitis, pneumonia. Upper and lower urinary tract infections such as pyelonephritis, urethritis, cystitis. Peritonitis, cholecystitis, intra- and extrahepatic cholangitis, other intra-abdominal infections. Septicemia . Meningitis . Skin and soft tissue infections. Bone and joint infections. Pelvic infection, endometriosis, gonorrhea, other genital infections. In addition, Avepzon is contraindicated in cases where the patient has a history of allergy to the antibiotics of the Penicillin group, Sulbactam, Cefoperazone or other excipients in the drug.

The dosage form of the drug is in the form of powder for injection, the drug is completely dissolved before injection or infused into the patient's body with distilled water with a volume of 5ml. The drug can be administered by intramuscular or intravenous infusion.
The following is the recommended dose of Avepzon:
Adults:
Mild and moderate infections: Use at a dose of 1-2g/time, every 12 hours. Severe infections: Use with a dose of 2-4g / time, every 12 hours. Children:
Use with a dose of 25-100mg/kg/time, every 12 hours. For patients with kidney failure: There is no need to adjust the dose of Avepzon for this group of subjects.
For patients with liver disease or biliary obstruction: Do not exceed 4g per day.
Note: The dose used above is for reference only. Each patient has different health and medical conditions, so it is not possible to use the same dose of medicine. Based on that, the treating doctor will prescribe an appropriate dose of medicine for each patient. Therefore, patients should not self-medicate without the doctor's prescription and instructions for use.

The doctor always considers the benefit that Avepzon brings to the patient and the possible risk of side effects to prescribe the appropriate drug.
Avepzon is well tolerated, these undesirable effects usually appear during the first time when taking the drug, usually mild or moderate side effects.
Some common side effects when taking Avepzon include:
Digestive system: Abdominal bloating, poor appetite, diarrhea, nausea, vomiting. Skin system: Skin allergy, erythema, urticaria. Hematopoietic system: Long-term use of the drug may cause reversible leukopenia, positive Coomb's reaction in some patients, decreased hemoglobin concentration and red blood cell count, possibly decreased white blood cell count. transient acidosis, thrombocytopenia and hypoprothrombinemia. Note: In addition to the side effects listed above, Avepzon may cause other unwanted effects that are not known. Therefore, during the course of taking the drug, the patient should monitor and immediately notify the doctor or pharmacist when there are any suspected side effects that may be caused by the drug.

Some drug interactions may occur when used in combination with Avepzon and other drugs such as:
When the patient uses alcohol, beer or alcohol can inhibit aldehyde dehydrogenase, causing accumulation in the blood and cause a disulfiram-like reaction. Characteristic reactions such as hot flushes, sweating, headache, and tachycardia have been reported with alcohol consumption during treatment with Avepzon, or after 5 days of dosing. Therefore, caution should be exercised when administering this drug to patients with other alcoholic substances. Avepzon should not be mixed with other aminoglycoside-containing drugs, which will reduce the drug's activity, due to the physical incompatibility between them. In cases where these drugs must be used in combination, an intermittent infusion should be performed, and the infusion tube should be flushed between the two doses. Or you can take the time between the two drugs. Lidocaine: This drug does not form an initial reconstituted solution with a 2% solution of lidocaine HCl and the suspensions are comparable. Sterile distilled water was used to make the initial reconstituted solution and diluted with 2% lidocaine to make a compatible solution. When used in combination with drugs such as anticoagulants, thrombolytics, non-steroidal anti-inflammatory drugs due to the potential to cause bleeding. Avepzon should not be mixed with drugs such as Amikacin, Gentamicin, Kanamycin B, Doxycycline, Meclofenoxate, Diphenhydramine, Potassium Magnesium aspartate to avoid precipitation. When mixed with hydroxylamine hydrochloride, Procainamide, Aminophyllin, Prochlorperazine, Cytochrome C, Pentazocin, Aprotinin, after 6 hours there is a change in the drug's properties. Clinical Laboratory Interactions: The urine glucose response may be falsely positive with Benedict's or Fehling's solution. Positive globulin resistance tests have been reported, in particular, in neonates whose mothers received Avepzon at the time of delivery. Occasionally increases in serum ALP, AST, ALT, BUN and serum creatinine have been observed. During the use of Avepzon, drug interactions may occur when used in combination with other drugs or food that are not mentioned above. In order to limit the occurrence of harmful interactions for patients, before being prescribed Avepzon by a doctor, patients need to inform them of all drugs they are taking, including prescription or non-prescription drugs, functional foods. , medicinal,...

Some notes when patients use Avepzon drugs are as follows:
Caution when using Avepzon for patients who have a history of allergy to Penicillin. Pseudomembranous colitis has been reported in patients receiving this drug. Patients should not drink alcohol or other alcoholic beverages while using Avepzon. Patients should take the drug according to the doctor's prescription, should not increase or decrease the dose of the drug. Adhere to the treatment time of the doctor to avoid taking the wrong drug, which may have the risk of drug resistance. Should not stop taking the drug suddenly when the clinical symptoms have improved... Absolutely do not give Avepzon to other people to drink if the disease condition has similar symptoms. Patients should check the expiration date on the package before taking the medicine, if the drug has expired, it should not be used. Each drug has a different shelf life recommended by the manufacturer, when the drug has expired, the active ingredients in the drug will be degraded, which can cause limited effects to the patient. Pregnancy: Avepzon can cross the placental barrier, although the potential risk to the fetus has not been clearly established. In case it is necessary to use the drug, it is advisable to consult a doctor to avoid consequences that may affect the fetus such as miscarriage, malformation,... Lactating women: According to clinical research, Avepzon is known to be excreted in breast milk, so it may affect the baby while the mother is breastfeeding. If a nursing patient must take Avepzon, breast-feeding should be discontinued before starting treatment.

When the patient forgets to take the medicine, take the dose as soon as you remember it. Usually drugs that can be taken 1-2 hours after the daily dose do not affect the treatment. The patient should not take the missed dose if it is almost time for the next dose of the day prescribed by the doctor. Absolutely, patients should avoid taking a double dose when they forget to take the medicine. If you accidentally take an overdose of the drug as directed by the treating doctor, some side effects may occur such as increased neuromuscular excitability, convulsions, and seizures, which are common in patients with kidney failure. Patients should stop taking the drug immediately, self-monitor for changes in the body if any symptoms are suspected related to drug overdose. Immediately notify your doctor or pharmacist for advice on appropriate treatment. When the symptoms become more severe, the patient should be taken to the hospital immediately for timely treatment to avoid serious complications. Patients should also remember to bring the used medicines with them so that the doctor can understand the information and handle it quickly and promptly. Hopefully, the above article has provided all relevant information on usage, uses, dosage and some notes when using Avepzon. Patients need to take Avepzon exactly as directed by the treating doctor. Note, Avepzon is a prescription drug, patients can only use this drug when prescribed by a specialist.