Uses of Bidipera

Metoclopramide is a drug used to treat and prevent symptoms of vomiting and nausea quite popular today. One of the products containing this active ingredient is the drug Bidiperan. Here are some information to keep in mind when using Bidiperan.

Bidiperan is a drug belonging to the group of gastrointestinal drugs. Bidiperan is prepared in the form of a 2ml syringe containing the main active ingredient, Metoclopramide, 10mg. The drug is manufactured by Binh Dinh Pharmaceutical & Medical Equipment Company (BIDIPHAR) - VIETNAM, circulating on the market with registration number VD-1513-06.

Metoclopramide is a neuroleptic active ingredient that has an antagonistic effect on Dopamine, preventing symptoms of nausea due to inhibition of dopaminergic receptors, thereby stimulating gastrointestinal motility.
Metoclopramide increases peristalsis of the antrum, duodenum, and jejunum. Metoclopramide reduces the dilation of the upper stomach and increases the contractility of the antrum, making the process of gastric emptying happen faster, reducing reflux from the duodenum into the stomach and into the esophagus.

Bidiperan is indicated for use in cases of gastrointestinal motility disorders, gastroesophageal reflux disease or gastric stasis; Bidiperan is used to treat some forms of nausea and vomiting caused by migraine headaches, vomiting caused by cancer treatment with chemotherapy, or vomiting after surgery; Bidiperan has little effect on vomiting caused by motion sickness. Medicines can be used to make the small bowel catheterization procedure easier and to help empty the stomach quickly on X-rays.

Adults: 1 ampoule of Bidiperan every 8 hours, intravenously (IV) or intramuscularly (IM); Adolescents and children: dose of Bidiperan by weight, up to 0.5 mg/kg/day; Diagnostic X-ray of the gastrointestinal tract 1 - 2 ampoules of Bidiperan injected IM or IV 10 minutes before the scan; Renal failure: half dose of Bidiperan when ClCr < 40 mL/min; Adjust dose of Bidiperan in liver failure; The total daily dose of Bidiperan should not exceed 0.5 mg/kg body weight. It is necessary to reduce the dose of Bidiperan in cases of liver and kidney failure and when used in young children to prevent dystonia. The dose of Bidiperan prescribed by the doctor or according to the usual dose is:
Patients aged 15 - 19 years: 5mg/time, 3 times/day (with a weight of 30 - 59 kg or more), if the person weighs 60 kg Bidiperan dose or more: 10mg/time, 3 times/day.

Hypersensitivity to the components of the drug Bidiperan ; Patients with gastrointestinal bleeding, obstruction or perforation in the gastrointestinal tract due to the stimulation of gastrointestinal motility of the drug potentially dangerous to the patient.

Some side effects of Bidiperan such as: Restlessness, drowsiness, fatigue;
Attention and precaution: Asthma, kidney failure, heart failure, cirrhosis of the liver, hypertension, caution with the elderly, children, pregnant and lactating women.

Neurological side effects (extrapyramidal syndromes) may occur with the use of Bidiperan, especially in children and young adults; In case of partial or total vomiting of Bidiperan, the patient still needs to keep a gap with the dose before taking the drug again; In case of vomiting a lot, the patient needs to prevent the risk of dehydration by oral rehydration with a solution of "sugar - salt", taken several times, a little each time; Bidiperan should not be prescribed to patients with epilepsy (Bidiperan can increase the frequency and intensity of seizures); The dose of Bidiperan should be reduced in patients with liver and kidney failure; Note when using Bidiperan for subjects driving vehicles and machines about the possibility of falling asleep when using Bidiperan. In animals, the administration of Bidiperan had no teratogenic effects, similarly in humans no teratogenic effects have been observed so far at conventional doses of Bidiperan. Mothers can breastfeed if only taking Bidiperan temporarily (eg to prevent vomiting after Cesar surgery) provided that the breastfed baby is born at term and is in good health. In case the baby is born prematurely or the mother is taking Bidiperan for long-term or high-dose treatment, breast-feeding is not recommended. Therefore, for lactating women, the use of Bidiperan should be weighed against the benefits and risks. In general, Bidiperan can be used under a doctor's prescription if necessary.

Contraindications to the combination of dopaminergic drugs including non-Parkinsonian drugs, Levodopa with drugs containing Metoclopramide such as Bidiperan; Anticholinergics, morphine derivatives that have a competitive antagonism with Bidiperan in terms of effects on gastrointestinal motility; Co-administration of Bidiperan with central analgesics (morphine derivatives, anti-anxiety drugs, H1-antihistamines, antidepressants, barbiturates, clonidine and other related drugs) may increase psychotic effects. ; Metoclopramide may enhance the neuroleptic effects of neuroleptics and cause extrapyramidal disorders, increase the risk of serotonin syndrome of serotonergic drugs, decrease the bioavailability of digoxin and increase bioavailability. of the drug Cyclosporin; Metoclopramide parenteral administration may prolong the neuromuscular blocking effects of the active ingredients Mivacurium and Suxamethonium; Strong CYP2D6 inhibitors such as fluoxetin and paroxetin increase patient exposure to Bidiperan.