Uses of Clamisel 500

What is Clamisel 500mg? The drug has the main ingredient is Clarithromycin 500mg and other excipients. Clarithromycin is a semi-synthetic macrolide antibiotic of erythromycin A. It is highly effective against gram-negative, gram-positive, anaerobic and aerobic bacteria.
Indications for use of Clamisel 500: Used in cases of infections caused by 1 or more susceptible bacteria:
Lower respiratory tract infections: Pneumonia, acute and chronic bronchitis; Upper respiratory tract infections: Pharyngitis, sinusitis, otitis media; Mild to moderate skin and soft tissue infections; Community-acquired respiratory infections, helping to combat the causative agent of atypical pneumonia; In combination with Omeprazol for the radical treatment of gastric ulcers caused by Helicobacter Pylori (HP); Prevention and treatment of Mycobacterium avium infections in immunocompromised patients, the prevention of opportunistic infections. Contraindications to the use of Clamisel 500:
People with a history of allergy to macrolide antibiotics; Concomitant use with terfenadine, especially in cases of heart disease such as torsades de pointes, arrhythmias, myocardial ischemia.

How to use: Take the tablet whole with water, can be taken before or after meals. Dosage and duration of medication will be prescribed by the doctor for each specific case. The usual duration of treatment with Clamisel is 7-10 days.
Dosage:
Respiratory, skin and soft tissue infections: Adults and children over 12 years old: Use a dose of 250mg x 2 times/day or 500mg/time/day. For severe infections, use 500mg/time x 2 times/day; Children under 12 years old: Use dose 15mg/kg/day, divided into 2 oral doses; Gastric - duodenal ulcer due to HP infection: Adults use a dose of 500mg x 2-3 times/day, combined with Omeprazole 40mg/time/day for 14 days; Infections caused by Mycobacterium: Use a dose of 500mg x 2 times / day, treatment for 3-4 weeks. If the treatment is not effective, the dose can be increased to 1g x 2 times/day; In patients with severe renal impairment (CC less than 30ml/min), with or without hepatic impairment: Dosage should be adjusted, reducing the total daily dose by 1/2. Specifically, use 250mg / time / day or 2 times in case of severe infection. Overdose: Overdose of Clarithromycin (the main ingredient of Clamisel 500) can cause gastrointestinal symptoms or altered mental status, hypokalemia and hypoxia. Allergic reactions associated with overdose should be treated with gastric lavage and supportive therapy.

Some side effects of Clamisel 500 include:
Common: Gastrointestinal disturbances, hypersensitivity reactions (itching, urticaria, irritation, skin rash), Stevens-Johnson syndrome, pseudomembranous colitis from mild to severe; Uncommon: Nausea, vomiting, abnormal liver function, upper abdominal pain, high serum bilirubin with jaundice, typhus, eosinophilia, deafness (reversible). Patients should inform their doctor about the side effects when using Clamisel 500 so that appropriate intervention measures can be taken.

Some notes users need to remember before and while using Clamisel 500 include:
Clarithromycin is mainly eliminated by the liver and kidneys, so caution should be taken when using the drug in patients with impaired liver and kidney function. ; Use with caution when using Clamisel 500 for prophylaxis or in infections caused by less susceptible bacteria (because the risk of resistance may increase); Prolonged and repeated use of Clamisel can cause the growth of fungi and bacteria that are no longer sensitive to the drug. If superinfection occurs, the drug should be discontinued and appropriate therapy instituted; In a small number of patients, H. pylori may become resistant to clarithromycin; There have been no studies on the use of Clamisel 500 in pregnant women, so this subject should consult a doctor before taking the drug; There have been no studies on the use of Clamisel 500 in lactating women, so caution should be exercised when using this drug in this population; There are no studies on the safety and effectiveness of Clamisel 500 in children under 20 months of age.

Some drug interactions of Clamisel 500 include:
When used concurrently with antiepileptic drugs, Clarithromycin (the main ingredient of Clamisel) inhibits the metabolism of carbamazepine and phenytoin, leading to an increase in their side effects. ; Clarithromycin inhibits the metabolism of cisplatin, causing ventricular fibrillation, torsades de pointes; inhibits the metabolism of theophylline and increases the risk of toxicity; The use of clarithromycin in patients taking warfarin may potentiate the effects of warfarin, so prothrombin time should be regularly monitored in these patients; Avoid the use of Clarithromycin in people taking terfenadine and other non-sedating antihistamines related to astemizole because it can cause cardiac arrhythmias; Clarithromycin reduces the absorption of zidovudine. When using Clamisel 500mg, patients should follow their doctor's instructions to ensure the best therapeutic effect and reduce the risk of unpredictable events.
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