Uses of Falcidin

Falcidin is a prescription drug belonging to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs. Falcidin is a product of Mekophar Chemical - Pharmaceutical Joint Stock Company.
Falcidin is made in the form of film-coated tablets, and is packaged in a box of 1 blister x 8 tablets.
Ingredients for 1 tablet of Facidin include:
Piperaquine phosphate.4H2O (Equivalent to 320 mg Piperaquine phosphate anhydrous) Dihydroartemisinin 40 mg Excipients just enough for 1 tablet: Lactose, Corn Starch, Starlac, Maltodextrin, Pregelatinized starch, Sodium starch glycolate, Hydroxypropyl cellulose, Polyethylene glycol 6000, Hydroxypropyl methyl cellulose, Titanium dioxide , Blue Patente, Quinolin yellow, Talc, Polysorbate 80, Ethanol 96%, Magnesium stearate.

Properties: Falcidin is an antimalarial drug that combines 2 drugs Piperaquine and Dihydroartemisinin in the same formula. Falcidin drug has fast acting, high efficiency, safety, low toxicity and short duration of therapy.
The drug is used to treat most forms of malaria, including strains that are resistant to antimalarial drugs such as chloroquine, 4-aminoquinolin derivatives, pyrimethamine proguanil and drugs that combine pyrimethamine with sulphonamides.
The drug effectively inhibits and destroys spores of strong strains of Plasmodium and reduces malaria transmission.
Pharmacodynamics of the drug Falcidin
Dihydroartemisinin: Dihydroartemisinin mainly works to interfere with the membrane structure of autotrophs (asexual bodies in red blood cells) such as: twisting the digestive vacuole membrane, causing mitochondria and The nuclear membrane expands, separating the ribosome from the endoplasmic reticulum, leading to cytoplasmic vacuoles and autophagy. In addition, the drug has a biochemical effect on the synthesis of proteins and nucleic acids. Piperaquine phosphate: Piperaquine phosphate inhibits the physiological function of the digestive vacuole membranes of autotrophs, inducing autophagy of the parasite. Pharmacokinetics of falcidin Dihydroartemisinin: After oral administration, Dihydroartemisinin is rapidly absorbed, peak plasma concentrations are reached within 1 hour, and elimination half-life is about 4 hours. Widely distributed to liver, bile and kidney. Approximately 80% is excreted in the urine and faeces within 24 hours of oral administration. Dihydroartemisinn is metabolized to two inactive forms, deoxydihydroartemisinin and dihydroxydihydroartemisinin.
Piperaquine Phosphate: Piperaquine has high lipid solubility with large volume of distribution, stable bioavailability, relatively long elimination half-life, clearance coefficient. ) was significantly higher in children than in adults.
After oral administration, approximately 80-90% of Piperaquine phosphate is absorbed in 24 hours. The drug is widely distributed in the body, mainly in the liver, kidneys, lungs and spleen. Approximately 25% of a dose is metabolized in the liver within 8 hours of oral administration. Piperaquine Phosphate is slowly eliminated and has a long half-life of about 9 days. The drug is excreted in the bile by the enterohepatic cycle.
Thanks to the above properties and pharmacology, the drug Falcidin is indicated in the following cases:
Treatment of most types of malaria caused by Plasmodium falciparum, Plasmodium oval, Plasmodium vivax, Plasmodium malaria, including polymorphic strains resistant to other antimalarial drugs.

Dosage and use of Falcidin is as follows:
Adults
Dosage is as follows: Day one: take 4 tablets divided into 2 times; 2nd day: 2 capsules, 3rd day: 2 capsules. Pregnant or lactating women, if necessary, must follow the doctor's prescription.
Children
Can be used in powder form for oral suspension.
Children from 3 to 6 years old: day 1: 1 tablet divided into 2 times; 2nd day: 0.5 tablets; Day 3: 0.5 tablets. Children from 7 to 10 years old: day 1: 2 tablets divided into 2 times; 2nd day: 1 tablet; Day 3: 1 tablet. Children from 11-14 years old: day 1: 3 tablets divided into 2 times; 2nd day: 1.5 tablets; Day 3: 1.5 tablets. Children under 3 years old use falcidin medicine as prescribed by the doctor. Usage: The drug should be taken after meals.

Contraindicated to use Falcidin drug in the following cases:
Do not use Falcidin drug for people who are sensitive to one of the ingredients of the drug. Falcidin should not be used in children under 2 years of age.

Side effects of this drug are usually mild and appear transient as follows:
Gastrointestinal reactions: loss of appetite, nausea, vomiting, diarrhea,... Allergic reactions: itchy skin, In the process of using Falcidin, if you encounter any undesirable side effects, please stop using the drug and notify your doctor.

Avoid combining falcidin with substances with antioxidant effects such as vitamin C, vitamin E, glutathione, ... because these substances will reduce the anti-malarial effect of the drug.

Caution and note when using Falcidin drug in the following cases:
Caution when using the drug in pregnant women in the first 3 months of pregnancy and breastfeeding women. Eye examination should be performed before long-term use of falcidin and monitored during treatment. Store Falcidin in a dry place, the temperature does not exceed 30 degrees Celsius, away from direct light. Falcidin is a prescription drug belonging to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs. The drug is prescribed by doctors to treat most forms of malaria, especially strains that have been resistant to previous anti-malarial drugs. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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