Uses of Farnatyl

Farnatyl has the main active ingredient Nizatidine, which is a competitive inhibitor of histamine H2 in gastric parietal cells. The drug is used in cases where it is necessary to reduce gastric acid secretion, thereby helping to relieve the symptoms of stomach pain, heartburn and heartburn caused by acid reflux.

Farnatyl has the main active ingredient, Nizatidine, because the drug has a formula similar to histamine, so the drug competes with histamine at the H2 receptor in the stomach parietal cells. The drug works by blocking the secretion of gastric juice, thereby helping to relieve the symptoms of stomach pain, heartburn and heartburn caused by acid reflux. Farnatyl has the effect of reducing both the amount and concentration of HCl in the gastric juice.
Farnatyl is prepared in the form of hard capsules, each containing 300mg Nizatidine.

Farnatyl is indicated for use in the following cases:
Benign progressive gastric ulcer. Progressive benign duodenal ulcer. Prophylactic treatment of duodenal ulcer or progressive gastric ulcer. Gastroesophageal reflux . Functional heartburn. Peptic ulcer disease caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs).

Farnatyl is contraindicated in the following cases:
Patients who are allergic to nizatidine or any of its components Because of cross-sensitization between compounds belonging to the H2 receptor antagonist group, it is contraindicated. Use Farnatyl in patients with a history of allergy to H2 antihistamines.

4.1. How to use Farnatyl Drug Farnatyl is made in the form of hard capsules, each containing 300mg nizatindin, for oral use. Before taking the drug, patients should consult their doctor or read the instructions for use to know the correct information about Farnatyl. When taking, swallow the tablet whole, take it with a glass of water before meals or at night before going to bed for the best effect.
For patients with dysphagia who cannot swallow capsules whole, Farnatyl capsules can be opened and mixed with water to drink.
4.2. Dosage of Farnatyl Progressive Duodenal Ulcer: The recommended adult dose is 300mg/day, taken once in the evening, or 150mg/time x 2 times/day, 30 minutes before meals. Progressive benign gastric ulcer: The recommended adult dose is 300mg/day, taken once before bedtime, or 150mg/time x 2 times/day, 30 minutes before meals. Before starting the drug, the patient should exclude the possibility of malignancy (stomach cancer, esophageal cancer, ..). Gastroesophageal reflux disease: Oral dose for adults to treat mucosal inflammation, gastric ulcer accompanied by heartburn sensation is 150mg/time x 02 times/day 30 minutes before meals, evening dose 600mg/day in 2 divided doses for 24 hours. Relieve symptoms of indigestion: 75mg each time, can be repeated if necessary, up to 150mg/day, for 14 days. Prophylaxis of progressive gastric and duodenal ulcers:: 75 mg orally 30-60 minutes before meals or once or twice daily (maximum dose 150 mg/day), for no more than 2 weeks. For patients with renal failure: adjust dose according to creatinine clearance. If clearance is less than 50 mL/min, the dose should be reduced. For patients with severe hepatic impairment: Dosage should be reduced (1/3 dose) and 150mg capsules, especially in combination with renal impairment (Farnatyl is partially metabolized in the liver).

Common undesirable effects
On the skin: Rash, itching, exfoliative dermatitis. Respiratory system: Cough, runny nose, sore throat, sinusitis. Cardiovascular system: chest pain. Uncommon side effects
Body as a whole: Fever, infection. Increased uric acid in the blood. On the skin: urticaria. Digestive system: Abdominal pain, diarrhea, constipation, dry mouth, vomiting. Rare adverse effects
Systemic and skin: Dizziness, fatigue, insomnia, headache, Hypersensitivity: Anaphylaxis, angioedema, laryngeal edema, bronchospasm, vasculitis, disease serum, Stevens-Johnson syndrome. Blood: Leukopenia, thrombocytopenia or all 3 lines. Cardiovascular system: Arrhythmia (tachycardia or bradycardia), orthostatic hypotension, syncope. On the liver: Hepatitis, jaundice, cholestasis, increased liver enzymes. Nervous system - Psychiatric: Restlessness, hallucinations, confusion. Endocrine system: Decreased libido, gynecomastia in men. Musculoskeletal system: Muscle pain, joint pain. On the eye: Visual disturbances.

When using Farnatyl, patients should note the following information:
Before using Farnatyl to treat stomach ulcers, the possibility of cancer must be excluded, because the drug can mask symptoms and slow down cancer diagnosis. Use with caution and reduce dose and/or prolong dosing intervals in patients with renal impairment (creatinine clearance < 50 ml/min) because the drug is eliminated primarily by the kidneys. Consider the risk/benefit of using Farnatyl in patients with cirrhosis or impaired liver function (which may require a dose reduction or an increase in dosing interval). Pregnant women: Farnatyl crosses the placenta. Studies using Farnatyl in pregnant women are incomplete, so use the drug only when clearly needed by your doctor and when it is found that the benefits outweigh the risk of unwanted side effects. Lactation: Farnatyl may be excreted in human milk. The mother should stop breastfeeding while taking the drug or stop taking the drug because it may cause unwanted side effects to the nursing infant. Effects of the drug on drivers and operating machines: When using Farnatyl in these subjects, the dosage should be cautious.

When using Farnatyl concomitantly with preparations, the following drugs may cause undesirable side effects:
Farntyl's nighttime inhibition of gastric acid secretion may be reduced by smoking. . Therefore, people with stomach ulcers should stop smoking or at least avoid smoking after taking the last dose of Farnatyl for the day. Farnatyl is used to increase gastric pH, so it may affect the absorption of some other drugs. Patients take other drugs 1-2 hours apart from Farnatyl. Concomitant use of Farnatyl with other drugs of the same class of H2 receptor antagonists may decrease drug absorption. Patients are advised not to take any antacids within 1/2-1 hour after taking Farnatyl. Drugs that cause myelosuppression: Chloramphenicol, cyclophosphamide... used together with Farnatyl may increase neutropenia or other hematopoietic disorders. The antifungals Itraconazole or ketoconazole, when taken with Farnatyl, will significantly reduce the absorption of these two drugs. Therefore, Farnatyl must be taken at least two hours after itraconazole or ketoconazole. Salicylate: Farnatyl may increase salicylate serum concentrations when co-administered with high doses of acetylsalicylic acid. Sucrafat: Reduces the absorption of Farnatyl, therefore, Farnatyl must be taken 2 hours before sucralfate. To ensure safety and avoid side effects of Farnatyl, patients should read the instructions carefully before using or follow the instructions of the doctor or pharmacist. In case the use of Farnatyl is not effective, the patient should not arbitrarily take the drug for a long time, should go to the medical facility for examination and appropriate treatment.