Uses of Klamex

Klamex drug is prepared in the form of powder for oral suspension, with the main ingredients being Amoxicillin trihydrate equivalent to Amoxicillin 250mg, Clavulanate potassium and silicon dioxide equivalent to clavulanic acid 31.25mg and other excipients just enough for 1 tablet. The drug is used to treat respiratory infections. Below is detailed information about what Klamex is and what precautions to take.

1. What is Klamex?

The Amoxicillin component in Klamex is a semi-synthetic beta-lactam antibiotic with a broad spectrum of antibacterial activity against many Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. However, Amoxicillin is not effective against beta-lactamase-producing bacteria because the lactam ring is destroyed by this enzyme. Therefore, combining with clavulanic acid helps Amoxicillin not be destroyed by beta-lactamase, and at the same time expands the antibacterial spectrum of the drug to many beta-lactamase-producing bacteria without changing the drug's mechanism of action.
Amoxicillin is sensitive to gram-negative and gram-positive bacteria such as streptococcus, non-penicillinase-producing staphylococci, H. influenzae, E.coli, N.gonorrhoeae, Diplococcus pneumoniae and proteus mirabilis.
Amoxicillin is not sensitive to penicillinase-producing bacteria, especially methicillin-resistant staphylococcus, strains of Pseudomonas, Enterobarte and Klebsiella.

2. Uses of the drug Klamex

Klamex drug is used in the following cases:
Upper respiratory tract infections: tonsillitis, otitis media, sinusitis. Lower respiratory tract infections: acute/chronic bronchitis, bronchopneumonia, lobar pneumonia. Genitourinary tract infections: urethritis, cystitis, pyelonephritis. Skin and soft tissue infections: abscesses, boils, wound infections, cellulitis. Bone and joint infections: osteomyelitis. Dental infection: alveolar abscess. Other infections such as miscarriage, abortion, obstetric infections, and intra-abdominal infections. Do not use Klamex in the following cases:
History of allergy to beta-lactams (Penicillin and Cephalosporins). People with a history of liver dysfunction, jaundice caused by taking Amoxicillin and Clavulanate or other penicillins because Clavulanic Acid increases the risk of intrahepatic cholestasis.

3. Dosage and how to use Klamex

3.1. Dosage is calculated according to Amoxicillin in the compound. Adults and children over 40kg:
People with normal kidney function: 80mg/kg/day, divided into 3 times/day, the total dose should not exceed 3g/day.
People with impaired renal function:
Creatinine clearance > 30 ml/min: No dose adjustment is required. Creatinine clearance 10 - 30 ml/min: Dosage should not exceed 15mg/kg/time x 2 times/day. Creatinine clearance < 10 ml/min: Dosage should not exceed 15 mg/kg/day. People on hemodialysis: 15 mg/kg/day during and after hemodialysis. Children under 40kg: Take 20-40mg/kg/day, divided into 3 times/day, depending on the degree of infection.
3.2. How to use Take the drug with food to ensure tolerance in the gastrointestinal tract. The course of treatment can last from 5 to 10 days and not more than 14 days.

4. Klamex drug side effects

When using Klamex, patients may experience some of the following undesirable effects:
Commonly are digestive disorders (stomach pain, nausea, vomiting, diarrhea), fatigue, itching, hives. , rash on the skin; Uncommon: Eosinophilia, hepatitis, elevated liver enzymes, cholestatic jaundice, which can be severe and persist for several months; Rare: anaphylaxis, Quincke's edema, leukopenia, thrombocytopenia, hemolytic anemia, pseudomembranous colitis, exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, inflammation interstitial kidney. When using Klamex, if the patient experiences any side effects, stop taking the drug and contact the treating doctor or immediately go to a medical facility for timely treatment.

5. Interactions with drugs Klamex

When using Klamex simultaneously can interact with some of the following drugs:
Concomitant use with anticoagulants may prolong Prothrombin time, increase the risk of bleeding, so it is necessary to adjust the dose of anticoagulants. crowded when needed. Concomitant administration of Amoxicillin with Allopurino l may significantly increase the likelihood of rash in patients. The drug can affect the intestinal microflora, reduce the reabsorption of estrogen, and reduce the effectiveness of oral contraceptives containing estrogen and progesterone. Amoxicillin can cause a false-positive reaction for glucose in the urine. Concomitant use with Probenecid may reduce the renal tubular secretion of Amoxicillin, increasing the concentration of Amoxicillin in the blood. Nifedipine may increase the absorption of Amoxicillin. Methotrexate, when used in combination with Amoxicillin, can reduce excretion, increase toxicity of the drug on the gastrointestinal tract and hematopoietic system.

6. Notes and cautions when using Klamex

When using Klamex, caution should be exercised in the following cases:
Be careful with people with cholestatic jaundice, impaired liver and kidney function. Symptoms of cholestatic jaundice are rare but can be severe, but usually recover after 6 weeks of stopping the drug. Prolonged use of the drug can cause drug resistance. Use caution when using drugs for pregnant or lactating women, use only when absolutely necessary and under the guidance of the treating doctor. The ability to drive or use machines is not affected while taking the drug. The article has provided Klamex information, dosage and usage notes. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Klamex exactly as directed by your doctor.

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Bài viết này được viết cho người đọc tại Sài Gòn, Hà Nội, Hồ Chí Minh, Phú Quốc, Nha Trang, Hạ Long, Hải Phòng, Đà Nẵng.