Uses of Miaryl 2mg

Miaryl 2mg drug is prepared in the form of green tablets (can be broken in half), with the main ingredients including:
Active ingredient: Glimepiride 2 mg. Excipients: Microcrystalline cellulose 101, Lactose monohydrate, Povidone K30, Sodium starch glycolate, Sodium lauryl sulfate, Fast green, Yellow tartrazine, Magnesium stearate just enough 1 tablet 2 mg. Mechanism of Action Glimepiride is an orally administered sulfonamide belonging to the new generation of sulfonylurea hypoglycemic agents, used in the treatment of non-insulin dependent diabetes mellitus (type 2 diabetes mellitus). The main mechanism of action of Glimepiride in the pancreas is to bind to protein receptors in the beta cell membranes of the islets of Langerhans, thereby closing ATP-dependent potassium channels that depolarize the membrane. Then, the calcium channel will be opened to allow calcium ions to enter the cell, which stimulates the release of insulin from the beta cells.
In addition to the pancreas, Glimepiride increases the insulin sensitivity of peripheral cells, while reducing insulin reabsorption in the liver. In addition, Glimepiride increases the number of glucose transporters of fat and muscle membranes, thereby helping these tissues to increase glucose utilization.

Miaryl 2mg is indicated for the treatment of patients with non-insulin dependent diabetes mellitus (Type 2 diabetes mellitus), whose blood glucose levels cannot be controlled by diet, exercise or simple weight loss. pure.

Miaryl 2mg is contraindicated in the following cases:
Patients with insulin dependent diabetes mellitus (Type 1 diabetes) Diabetic patients with complications of ketoacidosis. Diabetic patients with pre-coma or coma complications. Severe liver and kidney dysfunction. Pregnant or lactating women. Hypersensitivity to any of the ingredients of the drug. History of allergy to other sulfa drugs. History of allergy to drugs containing the active ingredient Glimepiride.

4.1. How to use Patients need to drink before or during breakfast or the first main meal of the day. Do not chew the medicine. Do not make up for a missed dose or take an overdose. 4.2. Dosage Adults
Starting dose: Take 1⁄2 tablets (1mg)/time x 1 time/day. Up to 8 mg/day. After 1-2 weeks: Take 1 tablet (2mg)/time x 1 time/day if blood glucose is not controlled. People with impaired renal function: Usual dose: Take 1⁄2 tablets (1mg)/time x 1 time/day.
People with impaired liver function: Not recommended for use.
Users of Miaryl 2mg instead of other antidiabetic drugs: Usual dose: Take 1⁄2 tablets (1mg)/time x 1 time/day.
4.3. Recommendations After taking the usual dose of 1⁄2 tablets (1mg)/day, the blood glucose level should be lowered, the patient should switch to treatment with diet and exercise. Change the dose of Miaryl 2mg to avoid hypoglycemia when the patient's weight, lifestyle changes or when Miaryl 2mg is used with drugs that increase or decrease blood glucose. Miaryl 2mg should be used in combination with Metformin or Glitazone when a single dose does not control blood glucose. Miaryl 2mg should be used in combination with insulin when a single dose of 4 tablets (8mg)/day does not control blood glucose. Monitor blood glucose daily when deciding to use combination of blood glucose lowering drugs.

Side effects encountered when using Miaryl 2mg
Treatment with Miaryl 2mg drug in high doses or for a long time, can cause side effects as follows:
Common: Gastrointestinal disturbances such as nausea, vomiting, bloating, abdominal pain, diarrhea. Neurological symptoms such as headache, dizziness, dizziness. Symptoms of temporary visual disturbances. Uncommon: Systemic symptoms such as allergic reactions, urticaria, itching, severe erythema that may cause anaphylaxis Rare: Abnormalities in blood count such as hemolytic anemia, agranulocytosis, decreased 3 blood cell lines : Red blood cells, white blood cells, platelets. Skin symptoms such as hypersensitivity to light. Abnormal liver function such as increased liver enzymes, jaundice. Symptoms of allergic vasculitis. Patients should stop taking the drug as soon as they detect the above symptoms after using Miaryl 2mg or quickly notify the treating doctor and immediately go to the nearest medical facility for supportive treatment.
Note to use Miaryl 2mg in subjects
Be careful when using Miaryl 2mg in people with impaired liver function, severe kidney, adrenal insufficiency, hypopituitarism because it is easy to cause hypoglycemia. Monitor closely when using Miaryl 2mg drug on elderly patients, who use sympathomimetic drugs, Beta-blockers, because hypoglycemia is difficult to detect. Pregnant women: The active ingredient Glimepiride in Miaryl 2mg can cause fetal toxicity, teratogenicity, so it is contraindicated to use in this subject. Breastfeeding women: There are currently some studies showing that the active ingredient Glimepiride in Miaryl 2mg can be excreted in breast milk, thereby causing toxicity to the baby. Therefore, the use of Miaryl 2mg is contraindicated in this subject. Drivers or machine operators may experience side effects after using Miaryl 2mg. Therefore, extreme caution should be exercised when performing these tasks.

Interactions with other drugs
Drugs that increase the blood glucose-lowering effect of Miaryl 2mg:
Insulin Other glucose-lowering drugs. Chloramphenicol . Coumarin derivatives. Cyclophosphamide . Disopyramide. Ifosfamide . MAO inhibitors. Non-steroidal anti-inflammatory drugs (NSAIDs). Probenecid . Miconazole. Quinolone drugs. Sulfamide group drugs. Antihypertensive drugs such as beta blockers, ACE inhibitors. Anabolic steroids. Male sex hormone. Drugs that increase blood glucose when combined with Miaryl 2mg:
Diuretics such as Thiazides. Corticosteroid drugs. Diazoxide. Catecholamines and other sympathomimetic agents. Glucagon. Nicotinic acid. Medicines containing estrogen. Phenothiazines. Phenytoin . Medicines containing thyroid hormone. Rifampicin. Above is the general information and notes when using Miaryl 2mg. In order to bring the best treatment results for themselves and their families, patients should carefully read the instructions for use on the packaging of Miaryl 2mg product and strictly follow the instructions of the treating doctor.
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