Uses of Modom's

Modom's drug, whose main ingredient is domperidone, is often used as an antiemetic but does not affect dopamine receptors in the brain, so it does not affect the mind and nerves. So what is Modom's drug?

What is Modom's drug Modom's drug has the main ingredient domperidone, which is a dopamine antagonist, with properties similar to metoclopramide hydrochloride, which helps to stimulate peristalsis of the gastrointestinal tract, increases the tone of the cardiac sphincter and increases the opening amplitude. expansion of the pyloric sphincter after a meal but does not affect gastric secretion. Modom's drug is often used for indications in the following cases:
Nausea, vomiting, loss of appetite, bloating, indigestion, heartburn, belching in chronic gastritis, gastroesophageal reflux disease (GERD) , symptoms after gastrectomy, taking anti-cancer drugs or L-dopa Children: periodic vomiting, upper respiratory infections, taking anti-cancer drugs Modom's drug is contraindicated in the following cases:
Ex: gastrointestinal bleeding, mechanical intestinal obstruction, intestinal perforation, vomiting after surgery Hypersensitivity to any component of Modom's drug Patients with severe and moderate hepatic impairment Patients with prolonged conduction time of cardiac impulses, especially QT interval Electrolyte disturbances with significant symptoms Patients with cardiovascular problems such as congestive heart failure Concomitant use of CYP3A4 inhibitors or drugs that prolong the QT interval

Modom's drug is usually used orally, patients should swallow the tablet whole with a full glass of water, absolutely do not chew or break the tablet, because it may affect the treatment effect. Patients should take the medicine before meals and at a fixed time of the day. The duration of each course of treatment should not exceed 1 week. Depending on the patient and the treatment goal, Modom's drug will be used in different doses, specifically as follows:
For nausea due to any cause:
Adults: 10-20 mg, every 4 -8 hours, maximum 30 mg/day Children: 0.2-0.4 mg/kg every 4-8 hours Modom's drug is not recommended for prophylactic use of postoperative vomiting
For indigestion symptoms:
Adults: 10-20 mg, 3 times/day before meals and 10-20 mg in the evening, the duration of use should not exceed 12 weeks. Special subjects:
Patients with hepatic impairment: mild cases do not require dose adjustment, Modom's drug is contraindicated in patients with severe and moderate hepatic impairment Patients with renal impairment: due to prolonged half-life of the drug. In patients with severe renal impairment, it is necessary to reduce the number of doses to 1-2 times/day and adjust the dose based on the degree of renal impairment.

In some patients when using Modom's, side effects may occur such as:
Headache, nervousness, drowsiness Itching, rash, transient allergic reaction Lactation, male enlargement of breasts, breasts tightness or pain Dry mouth, thirst, abdominal cramps Diarrhea Decreased libido Cardiovascular disturbances QT interval prolongation, ventricular arrhythmias, torsades de pointes

Some general notes when using Modom's drug include:
Use the drug at the lowest effective dose. It is necessary to stop treatment and report to the doctor when the patient has symptoms of arrhythmia Do not use the drug too much. 12 weeks in Parkinson's disease, use in this patient only when other safe antiemetic measures have not been effective. Do not use Modom's in pregnant women, because there are not enough safety data when used in this group. This drug is likely to be excreted in human milk and therefore may cause adverse effects on the cardiovascular system Some common drug interactions with Modom's:
Drugs that inhibit the effects of domperidone: anticholinergics , muscarinic drugs, opioid analgesics Drugs that prolong QT interval are dangerous when combined with Modom's: class IA, III antiarrhythmic drugs, antipsychotics, antibiotics (erythromycin, levofloxacin,... ), anti-malarial drugs such as Lumefantrine, protease inhibitors Modom's drug has the main ingredient domperidone which is an active ingredient. Dopamine resistance. The drug is effective in reducing the symptoms of nausea and other gastrointestinal diseases.