Uses of Myopain 50

Myopain 50 has the main ingredient Tolperison, which belongs to the group of muscle relaxants and increases muscle tone. In order for the use of Myopain 50 to be highly effective, patients need to take the drug exactly as directed by the doctor or pharmacist.

What is Myopain 50? The drug Myopain 50 has the main ingredient Tolperison, which is prepared in the form of film-coated tablets and the packaging is a box of 5 blisters x 10 tablets.
Uses of the drug Myopain 50, which are:
Treatment of spasticity after stroke in adults; Treatment of pathological skeletal muscle hypertonia in organic neurologic disorders, hypertonia, muscle spasms and spasms associated with motor disease; Used in rehabilitation after trauma surgery - orthopedic; Treatment of thromboembolic diseases as well as syndromes that appear, because of impaired vascular nerve distribution.

2.1. How to use Myopain 50 is taken into the body through oral route. The patient can take the drug during or after a meal.
2.2. Dosage Normally, Myopain 50 is used with a dosage of 50-150mg x 3 times/day.
Dosage in patients with renal failure: Information on the use of Myopain 50 is limited, but there have been reports of an increase in the incidence of adverse health events in this group of patients. In patients with moderate renal impairment, it is necessary to determine the appropriate dose for each patient in combination with close monitoring of disease status and renal function. Patients with severe renal impairment are not recommended to use tolperison. Dosage in patients with hepatic impairment: Dosage information is limited, but an increased incidence of adverse health events has been reported in this patient population. In patients with moderate hepatic impairment, it is necessary to determine the appropriate dose for each patient in combination with close monitoring of disease status and liver function. Patients with severe hepatic impairment are not recommended to use tolperison; Dosage in children: The safety and effectiveness of tolperison in children have not been established.

3.1. Contraindications Do not use Myopain 50 with people who are hypersensitive to tolperison or its ingredients.
3.2.Side effects During the use of Myopain 50, patients may experience some of the following side effects:
Allergies appear on the skin and subcutaneous tissue; General disorders; Effects on the nervous system; Digestive disorders . Most of these side effects are minor and go away on their own once the medication is stopped. In addition, life-threatening hypersensitivity reactions are highly unlikely, e.g. confusional state, increased sweating.
3.3. Precautions while using Myopain 50 The most commonly reported adverse reactions with tolperisone are hypersensitivity reactions. Specifically as follows:
Mild skin reactions: Appearance of rash, redness, urticaria, itching; Severe systemic reactions: Anaphylaxis; Angioedema, tachycardia, low blood pressure, shortness of breath. Females have a higher risk of hypersensitivity reactions or patients with a history of allergy or hypersensitivity to other drugs.
Patients sensitive to lidocaine should use caution when using tolperisone because cross-reactivity may occur.
Before use, patients should be aware of the potential for side effects when using tolperison. If you experience side effects while using the drug, you need to stop taking the drug and inform your doctor about the situation, seek appropriate advice. In the event of an adverse reaction, tolperison should not be re-administered.
For pregnant women: Animal studies have shown that tolperison is not teratogenic. However, human studies are lacking in clinical data, so caution should be exercised when using the drug in pregnant women, carefully weighing the benefits and risks when using the drug. In particular, pregnant women in the first 3 months of pregnancy are not allowed to use tolperison. Lactation: There are no adequate studies on whether tolperison is excreted in human milk. Therefore, the use of drugs is not indicated for this group of subjects. For the ability to drive and use machines: The drug can cause dizziness, lightheadedness, difficulty concentrating, blurred vision, so consider using the drug before driving or operating machinery.

Pharmacokinetic interaction studies on the CYP2D6 metabolizing enzyme with the substrate dextromethorphan showed that concomitant use of tolperisone may increase blood concentrations of drugs metabolised mainly by CYP2D6 such as thioridazine, tolterodin, venlafaxine, desipramine , dextromethorphan, metoprolol, nebivolol, perphenazine.
In vitro studies in human liver lobules and hepatocytes have shown no inhibition or reaction on other CYP isoenzymes (CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP1A2, CYP3A4).
In contrast, tolperisone concentrations were not affected by co-administration with drugs metabolised via CYP2D6 because tolperisone may be metabolized by other pathways.
The bioavailability of tolperisone is reduced if the drug is not taken with a meal. Therefore, patients should take the drug with meals or immediately after eating.
Myopain 50 is a centrally acting muscle relaxant with little sedation. In the case of concomitant use of tolperisone with other centrally acting muscle relaxants, a dose reduction of tolperisone should be considered if necessary. Tolperisone may potentiate the effects of niflumic acid, so a dose reduction of niflumic acid or other NSAIDs should be considered when co-administered with tolperisone.
In summary, the drug Myopain 50 has the main ingredient Tolperison, which belongs to the group of muscle relaxants and increases muscle tone. In order for the use of Myopain 50 to be effective, patients need to take the drug exactly as directed by the doctor or pharmacist.
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