Uses of Nalomel

Nalommel belongs to the group of gastrointestinal drugs, made in the form of capsules, the main ingredient is Esomeprazole. The drug is indicated in the treatment of gastroesophageal reflux in people with esophagitis, with severe reflux symptoms.

Nalomel belongs to the group of gastrointestinal drugs, made in the form of hard capsules containing enteric-soluble microparticles. The main ingredient of the drug is Esomeprazole (as esomeprazole magnesium dihydrate).
Nalomel is indicated in the treatment of gastroesophageal reflux disease in patients with esophagitis and/or severe reflux symptoms as an alternative when oral therapy is not appropriate.

Dosage for adults:
Treatment of erosive esophagitis: Use Nalomel 20 or Nalomel 40, once a day, continuously for 4-8 weeks; Maintenance treatment after recovering from esophagitis: Use Nalomel 20 ~ 20mg content, 1 time / day, for no more than 6 months; Treatment of gastro-oesophageal reflux: Nalomel 20mg dose, once a day, continuously for 4-8 weeks. Dosage for children 12-17 years old:
Short-term treatment of gastroesophageal reflux disease: Nalomel 20 or 40mg, once a day, continuously for 8 weeks. Dosage c children 1-11 years old:
Short-term treatment of gastroesophageal reflux: Nalomel 10mg dose, 1 time / day, continuously for 8 weeks; Treatment of erosive esophagitis: Children < 20 kg use 10mg/time, 1 time/day, continuously for 8 weeks; Children > 20 kg dose 10 or 20 mg/time, 1 time/day, continuously for 8 weeks. Dosage of Nalomel drug is used in other diseases:
Prophylaxis of gastric ulcers associated with non-steroidal anti-inflammatory drugs: Dose of 20 or 40 mg/time, 1 time/day, continuously for 6 months; H. pylori eradication reduces the risk of duodenal ulcer recurrence: Esomeprazole dose (40mg, once a day x 10 days); Amoxicillin (1000mg, twice a day x 10 days); Clarithromycin (500mg, twice daily for 10 days); Increased gastric acid secretion, including Zollinger-Ellison syndrome: 40mg/time, 2 times/day; Long-term treatment after using injection form to prevent recurrence of peptic ulcer bleeding: 40mg/day, 1 time/day, continuously for 4 weeks, people with severe liver failure should not use more than 20mg/day.

Nalomel is taken on an empty stomach, at least 1 hour before eating. When taking orally, swallow the tablet whole, do not chew or crush. For people with difficulty swallowing, put the tablet in a glass of non-carbonated water, stir it into tiny particles and drink it within 30 minutes. For people who cannot swallow, dissolve the drug as above and then give it through a nasogastric tube.

Nalomel is contraindicated in people with hypersensitivity to Esomeprazole, Benzimidazoles or any other ingredient of the drug. Note: Nalomel should not be taken together with Nelfinavir.

Some interactions that may occur when taking Nalomel with other drugs include:
Ketoconazole, iron salts, Digoxin: Nalomel inhibits acid secretion, so it increases gastric pH, affecting the bioavailability of these drugs. above drugs. Cilostazol : Increases concentrations of Cilostazol and its active metabolites, consider dose reduction of Cilostazol. Voriconazole: Increased exposure to Esomeprazole more than 2-fold, considered in patients receiving high doses of Esomeprazole (240 mg/day), eg in patients treated for Zollinger-Ellison syndrome. Inducers of CYP2C19 and CYP3A4 such as rifampin: Decreased concentrations of Esomeprazole. Drugs causing hypomagnesaemia such as thiazide diuretics or loop diuretics: Increased risk of hypomagnesaemia. Atazanavir : Reduces plasma drug concentrations, leading to a decrease in antiviral activity. Clopidogrel: Decreases plasma concentrations of the active metabolite of clopidogrel, reducing the antiplatelet effect. Digoxin: Prolonged use of Nalomel lowers blood magnesium, thereby making the myocardium more sensitive to Digoxin, increasing the risk of cardiotoxicity. Sucralfate: Administer Nalomel at least 30 minutes before taking sucralfate to limit the risk of inhibition of absorption and decrease the bioavailability of Nalomel. Tacrolimus: Increases serum concentrations of Tacrolimus. Warfarin: Increases INR and prothrombin time which can cause abnormal bleeding and death. Clarithromycin: Increases blood levels of Esomeprazole and 14-hydroxyclarithromycin. Diazepam: Decreased metabolism of Diazepam and increased plasma concentration of Diazepam.

Some possible side effects when taking Nalomel include:
Common: Headache, dizziness, skin rash, nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence, dry mouth. Uncommon: Fatigue, insomnia, somnolence, rash, pruritus, paresthesia, visual disturbances. Rare: Fever, sweating, peripheral edema, photosensitivity, alopecia, urticaria, angioedema, bronchospasm, anaphylaxis, agitation, depression, confusion, hallucinations, infection respiratory bacteria, pancytopenia, leukopenia, leukopenia, thrombocytopenia, increased liver enzymes, hepatitis, jaundice, impaired liver function, taste disturbance, stomatitis, hypomagnesaemia, hypomagnesaemia hyponatremia, porphyria, arthralgia, myalgia, osteoporosis, fracture, interstitial nephritis, gynecomastia, bullous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, dermatitis . Note, by reducing the acidity of the stomach, Nalomel may increase the risk of bacterial infections in the gastrointestinal tract.
In summary, Nalomel is indicated in the treatment of gastroesophageal reflux disease in people with esophagitis, with severe reflux symptoms. Because this is a prescription drug, patients should not use it on their own, but need to consult a doctor before using to ensure safety for health.