Uses of Nonfati

Nonfati is commonly used to treat the symptoms of osteoarthritis or rheumatoid arthritis. Nonfati is a prescription medication that carries a risk of adverse side effects. Therefore, the patient can only use the drug when specifically directed by the medical person in charge.

Nonfati is an anti-inflammatory drug, effective for cases of osteoarthritis. Nonfati medicine originated from Korea, is made in the form of film-coated tablets and packed in a box of 10 blisters x 10 tablets or a bottle of 30 tablets.
The main active ingredient of Nonfati is Nabumetone 500mg. In addition, the manufacturer also added a number of excipients to help increase the therapeutic effect of the active ingredient Nabumetone in the drug.

Uses of the active ingredient Nabumetone
Nabumetone belongs to the group of non-steroidal anti-inflammatory drugs, capable of inhibiting the synthesis of Prostaglandin. Some studies show that Nabumetone has no effect on the stomach lining. After oral administration, Nabumetone is rapidly absorbed from the gastrointestinal tract, followed by metabolism to the active metabolite 6-methoxy-2-naphthylacetic acid in the liver. This metabolite is known to effectively inhibit the synthesis of Prostaglandin.
In general, the active ingredient Nabumetone in Nonfati is largely absorbed in the small intestine. The metabolite 6-methoxy-2-naphthylacetic acid is strongly bound to plasma proteins and distributed throughout inflamed tissues. According to experts, Nabumetone has the ability to cross the placental barrier and enter breast milk. The half-life of Nabumetone in plasma is approximately 24 hours.
Because it is in the NSAIDS drug category, Nabumetone has effective analgesic, anti-inflammatory and antipyretic effects. However, Nabumetone is only capable of providing mild to moderate pain relief for conditions such as arthritis, trauma, menstrual cramps or other musculoskeletal conditions. Therefore, it is not addictive to use.
Indications and contraindications to using Nonfati drug
Nonfati drug is used according to a doctor's prescription to treat cases of painful swelling, stiffness due to rheumatoid arthritis or osteoarthritis. However, do not use Nonfati for the following patients:
People with a history of hypersensitivity or allergic reaction to the active ingredient Nabumetone or any of the excipients included in the drug formula. Nonfati is contraindicated in patients with a history of peptic ulcer disease or with this condition. Do not use Nonfati for people with severe liver failure, such as cirrhosis. Avoid using Nonfati for people with asthma attacks, acute rhinitis or urticaria caused by taking NSAIDs or Aspirin. Nonfati is contraindicated in patients undergoing or undergoing surgery. Nonfati drug is contraindicated for women in the last 3 months of pregnancy. Relative contraindications Nonfati for nursing mothers.

Nonfati is made in the form of tablets for oral use. Therefore, patients need to take the tablet whole with a glass of water about 240ml. Avoid taking Nonfati with other drinks containing alcohol, carbonated or containing other stimulants. Time to take Nonfati can be during or after meals, depending on the doctor's prescription for each patient.
During the treatment of osteoarthritis conditions with Nonfati, you need to adhere to the dose of the drug as prescribed by your doctor. Avoid arbitrarily adjusting or extending the use time without discussing with the medical person in charge. Below is the dose of Nonfati drug according to the general recommendation of the doctor:
Dosage for adults: Take 2 tablets / time / day. For cases of severe osteoarthritis, exacerbations or prolonged symptoms, you can take 4 more tablets twice a day. Dosage for the elderly: Do not take more than 2 tablets/day. In some cases, the doctor may prescribe a dose of 1 tablet / day is enough. Pediatric dose: Nonfati is not recommended for children because there are not enough studies on its safety in this population.

In addition to the treatment of osteoarthritis conditions, Nonfati drug also has the risk of causing some adverse side effects for patients during use, including:
Diarrhea, dry mouth, nausea , vomiting, bloody stools, digestive disorders and mouth ulcers. Constipation, flatulence, peptic ulcer/perforation, gastrointestinal bleeding, stomatitis or peptic ulcer. Loss of appetite, sudden weight gain, drowsiness, headache, tinnitus, visual impairment, paresthesia, edema and fatigue. Dizziness, weakness, jaundice, yellow eyes, pain in the right upper stomach, insomnia and low energy. Flu-like symptoms, hair loss, hives, sensitivity to light, swollen eyes, swollen throat, swollen lips, swollen ankles/feet/legs/hands, itching and fever. Tachycardia, increased sweating, pale urine, difficulty urinating, painful urination or back pain. Not all patients experienced these adverse reactions. Some side effects, although rare, can have serious consequences for the patient's health if not treated early. Therefore, if any of the above mentioned side effects occur during your treatment with Nonfati, you need to tell your doctor immediately to get a solution.

According to the doctor's recommendation, patients need to be cautious when treating with Nonfati if they are experiencing one of the following medical conditions:
People planning to become pregnant, pregnant or nursing mothers suck. You are taking any prescription or over-the-counter medications, supplements, herbs, or are on a special diet. People with a history of allergies to drugs, substances or foods. People with a history of liver disease, diabetes, kidney disease, stomach and intestinal problems such as perforation / ulceration / bleeding. People with a history of edema, swelling, nasal polyps, asthma or stomatitis. People with bleeding, blood disorders, blood vessel disease, blood clotting problems, high blood pressure heart disease (eg heart failure). People with dehydration, poor resistance, low sodium levels in the blood, alcoholism. In addition, patients should also note some of the following during the use of Nonfati:
Immediately notify the doctor if there are symptoms of Nonfati overdose, such as convulsions, difficulty breathing, sadness. vomiting, nausea, drowsiness, lack of energy or coma. Currently, measures to manage Nonfati drug overdose usually include gastric lavage, activated charcoal and a combination of other supportive therapies. Consider reducing the dose of Nonfati in patients with renal impairment with creatinine clearance less than 30ml/min. It is necessary to monitor the body's response when administering Nonfati to patients with liver failure. When taking Nonfati, patients are at risk of headaches, visual disturbances or dizziness. If these adverse symptoms are present, the patient should avoid driving or operating machinery. Using Nonfati for pregnant women and nursing mothers should consult a doctor carefully, avoid self-use. There is an increased risk of asthma attacks or angioedema with the use of Nonfati. Very rarely, Nonfati causes impaired liver function and nephrotic syndrome. Check the expiry date of Nonfati before using, if the medicine is past its expiration date and mold, deformation or watery appearance occurs, the medicine should be discarded according to the instructions.

In fact, some drugs can interact when taken at the same time with Nonfati and lead to certain disadvantages for the patient's treatment. Here are the drugs that interact with Nonfati that you should know about:
Aspirin, anticoagulant Warfarin, Heparin, Corticosteroids or selective Serotonin reuptake inhibitors increase the risk of stomach bleeding when taken together. with Nonfati. Probenecid used concurrently with Nonfati may increase the side effects of the active ingredient Nabumetone. Increases the side effects of Nabumetone when taking Nonfati with drugs such as Lithium, Cyclosporine, Quinolones and Methotrexate. Reducing the effectiveness of diuretics or ACE inhibitors when used with Nonfati Above is all information about Nonfati drug, patients should carefully read the instructions for use, consult your doctor / pharmacist doctor before use. Note, Nonfati is a prescription drug, patients absolutely cannot buy and treat at home because they may experience unwanted side effects.