Uses of Penzobact

Penzobact belongs to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs and is prepared in powder form for injection. The main ingredients of the drug are piperacillin and tazobactam are indicated for the treatment of lower respiratory tract infections, urinary tract infections, abdominal cavity. What should patients pay attention to before using Penzobact?

The composition of the drug Penzobact piperacillin belongs to the group of semi-synthetic antibiotics with a fairly broad antibacterial spectrum against both anaerobic as well as aerobic bacteria. The action of Penzobact inhibits cell wall synthesis and synthesis. The compound Tazobactam in Penzobact also has a strong inhibitory effect on many betalactamases, especially plasmid-mediated enzymes, which often cause resistance to penicillins and 3rd generation cephalosporins. The presence of this compound in Penzobact drugs. may increase the antibacterial spectrum of penicillins, including beta-lactamase-producing bacteria normally resistant to other organisms in the class. Therefore, with the compound tazobactam is a combination of the action of a broad-spectrum antibiotic and possibly beta-lactamase inhibitor.

Penzobact is indicated in the treatment of systemic or local infections confirmed or suspected due to susceptible organisms or lower respiratory tract infections. Or infections of the urinary system, which may be accompanied by complications, intra-abdominal infections, skin and soft tissue infections, sepsis, infections of gynecological products, polymicrobial infections. Furthermore, Penzobact has a synergistic effect with aminoglycosides against some strains of pseudomonas. Therefore, combination therapy can be used successfully, especially in patients with reduced resistance.

Penzobact used for adults and children over 12 years old is recommended dose is 4g piperacillin/0.5g tazobactam and injected every 8 hours. The total daily dose can be varied in amounts from 2.25g to 4.5g every 6 to 8 hours.
For children under 12 years of age, caution should be exercised when using the drug because there are not enough data on the effects of Penzobact in this subject
For patients with renal failure, using Penzobact should be adjusted according to creatinine clearance : Creatinine clearance 20-80 ml/min: Penzobact dosage is 12 g/1.5 g/day divided into 4 g/500 mg every 8 hours. For patients on hemodialysis, the maximum total daily dose of Penzobact is 8 g Piperacillin/ 1 g Tazobactam.
In addition, because a 4-hour dialysis cycle can remove 30-50% of piperacillin, after each dialysis cycle add Penzobact at a dose of 2 g/250 mg Piperacillin/ Tazobactam.
Duration of treatment for acute infections, Penzobact must be continued for at least 48 hours after the fever has stopped or the patient's clinical symptoms have been resolved.
Note: The recommended Penzobact dosage above is for reference only. Therefore, before using Penzobact, patients should follow the doctor's instructions.

Penzobact can cause some unwanted side effects during treatment. However, with each case of Penzobact side effects can occur in varying degrees from mild to severe.
Possible treatment-related reported side effects of Penzobact are phlebitis and thrombophlebitis. The most common clinical systemic adverse reactions may be related to the two components piperacillin and tazobactam with signs such as diarrhea, rash, erythema, pruritus, vomiting, allergic reactions, urticaria, infection, maculopapular rash, stomatitis, constipation, muscle weakness, hallucinations, dry mouth, hypotension, myalgia, superficial phlebitis, fever, flushing, edema, fatigue,... In some cases, more serious side effects may occur including eosinophilia, thrombocytosis, thrombocytopenia, hypokalemia, transient elevations of serum liver enzymes, and functional parameters. of the kidney
Some notes during the use of Penzobact:
For women who are pregnant and breastfeeding, caution should be exercised when using Penzobact. Patients should be advised to use Penzobact from their doctor, and carefully analyze the benefits and risks before using the drug. Penzobact may change how it works and increase its side effects. Therefore, to avoid Penzobact drug interactions, the patient should provide the doctor with a list of previously used drugs, including prescription and non-prescription drugs, herbs,... Short-term antibiotic use with High doses that can treat gonorrhea can mask and slow the onset of symptoms of syphilis. Although Penzobact has low toxicity to penicillin family of antibiotics, it is still necessary to periodically check the function of organs such as kidney, liver, hematopoiesis during long-term treatment with Penzobact The above is important information. About Penzobact, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.