Uses of Plariche

Plariche is made in the form of tablets with the main ingredient in each tablet is Glibenclamide 5mg. In order to use the drug effectively, patients need to learn some information about the uses, dosage and notes when using Plariche in the article below.

The main ingredient of Plariche is Glibenclamide, a sulfonylurea antidiabetic drug. Glibenclamide has the effect of reducing blood glucose levels, through increasing the sensitivity of pancreatic beta cells to glucose, thereby increasing insulin release.
The effect of Glibenclamide is dependent on the secretory function of beta cells. Glibenclamide may also increase blood insulin levels, reducing the clearance of insulin by the liver.
The mechanism of action of Glibenclamide in the treatment of diabetes is quite complicated. When first administered to patients with non-insulin dependent diabetes mellitus, Glibenclamide increases pancreatic insulin release. During the first months of treatment, sulfonylurea drugs increase insulin response. With long-term use of the drug, blood insulin levels will drop to pre-treatment levels, but blood glucose levels remain low.

Plariche is indicated in the following cases:
Type 2 diabetes. Plariche is contraindicated in the following cases:
Type 1 diabetes. Juvenile diabetes. Unstable diabetes. Diabetic coma. Acute symptoms of metabolic decompensation in infection or gangrene. Severe damage to the liver or kidneys. Lack of nutrition. Hypersensitivity to glibenclamide. Pregnant women. Women are breastfeeding. Pay attention to precautions when using Plariche in the following cases:
People with impaired renal function because the drug's metabolites also have a blood glucose lowering effect to a certain extent. People with cerebral arteriosclerosis. Elderly. People who are allergic to sulfonamides and sulfonamide derivatives may be cross-allergic to glibenclamide in Plariche. You need to stick to your diet and take your medication regularly for the treatment to be effective.

Plariche is used orally, taking it about 30 minutes before a meal. The dose of Plariche should be individualized to avoid hypoglycemia.
Dosage of Plariche drug should follow the doctor's prescription, the reference dose is as follows:
The usual starting dose is 2.5 - 5mg per day, taken 30 minutes before breakfast. If necessary, the dose should be adjusted, every 1-2 weeks, in increments of 2.5 mg, until the required blood glucose control is achieved. Maintenance dose is usually from 1.25 to 10mg/day. When using the drug with a dose higher than 10mg / day can be divided into 2 oral doses. The maximum dose is 15mg/day. When you are using other antidiabetic drugs and switch to Plariche: Start taking Plariche at a dose of 2.5 - 5mg immediately after stopping the previous drug. Then, if necessary, the dose of Plariche can be adjusted as above. In the elderly, malnourished, the dose should be reduced. Because the effects of glibenclamide in Plariche are relatively long-lasting, some argue that the use of this drug should be avoided in the elderly. People with liver or kidney damage, the first dose is 1.25mg/day. Above is information about uses, dosage and precautions when using Plariche. This is a prescription drug, so patients should not use it on their own, but need to consult and consult a doctor before using to ensure safety for health.