Uses of Rolnadez

Rolnadez drug is made in the form of film-coated tablets with the main ingredient in each tablet is Tamoxifen citrate equivalent to Tamoxifen 20mg. So what is Rolnadez drug effective and how to use it?

The main ingredient in Rolnadez is Tamoxifen, which is a non-steroidal anti-oestrogen. Tamoxifen acts primarily as an anti-oestrogen, inhibiting the effect of endogenous oestrogens, presumably by binding to the oestrogen-receptor.
However, clinical results show that Tamoxifen is effective even in tumors that are not related to the estrogen receptor, which suggests that there are some other mechanisms of action of the drug that are not known yet. Currently, scientists acknowledge that tamoxifen also has some estrogen-like effects on certain body parts such as the endometrium, bones and blood lipids.
Rolnadez is indicated in the following cases:
Treatment of breast cancer in oestrogen-dependent women that has metastasized. Adjuvant treatment of breast cancer in oestrogen-dependent women has been supplemented with chemotherapy in select cases. Adjuvant treatment for women at high risk of recurrence after primary breast cancer treatment. It is also used to stimulate ovulation in women with infertility due to anovulation. Rolnadez is contraindicated in the following cases:
People with hypersensitivity to tamoxifen. Porphyrin metabolism disorder. Spontaneous miscarriage, birth defects, fetal death, and vaginal bleeding have been reported with the use of tamoxifen during pregnancy. Therefore, Rolnadez should not be used by pregnant women. It is advisable to check if you are pregnant before using Rolnadez. Are using any other infertility treatments. Are being treated with Anastrozole - another breast cancer medicine. People with a personal or family history of idiopathic venous thrombosis. People with genetic diseases that increase the risk of blood clots. Pay attention to precautions when using Rolnadez in the following cases:
Patients with leukopenia, thrombocytopenia. Patient has pre-existing hyperlipoproteinemia. Liver failure. Pediatric patients, as the safety and effectiveness of Rolnadez have not been established in this population. When using Rolnadez for premenopausal women, the patient should be carefully monitored because the drug causes ovulation. Currently, it is not known whether the tamoxifen in Rolnadez is excreted in human milk, so Rolnadez should not be used in nursing women. A decision should be made whether to discontinue breast-feeding while taking or to discontinue Rolnadez, taking into account the importance of the drug to a nursing woman. Be careful when driving or operating machinery, because Rolnadez has side effects such as drowsiness, dizziness, blurred vision, ...

Rolnadez drug is used orally, taking the tablet whole with water, it can be taken with or without food.
Treatment of breast cancer: Use a dose of 20mg per day, can be divided into 1 or 2 times. Doses of up to 40 mg per day may be used, but no additional benefit has been observed. Treatment of infertility due to anovulation: In case of regular menstrual cycle but no ovulation: Use the starting dose of 20mg/day, taking the drug on the 2nd, 3rd, 4th and 5th days of the menstrual cycle. If there are no results, the drug can be used up to 40mg and then 80mg / day in the following courses of treatment. In case of irregular menstruation, in the first course of treatment can start using the drug on any day of the cycle. If there is no evidence of ovulation, continue with a second course, starting 45 days after the first course, with the dose increased as above. If there is a response, the next course of treatment will begin on day 2 of the menstrual cycle. If you forget a dose of Rolnadez, take it as soon as possible, unless it is almost time for your next dose. Do not take a double dose of Rolnadez prescribed.
Symptoms of Rolnadez overdose are acute neurotoxicity with manifestations such as tremor, unsteadiness, hyperreflexia, fatigue, and dizziness. These symptoms usually occur within 3 - 5 days of starting Rolnadez and resolve within 2 - 5 days after stopping the drug.
There is no specific treatment for Rolnadez overdose, mainly symptomatic and supportive treatment.

In general, Rolnadez is well tolerated, with much less side effects than oestrogens and androgens. The most common side effects of Rolnadez are hot flushes, nausea, and vomiting, which may affect up to 25% of users and are rarely severe enough to require discontinuation.
Very common side effects of Rolnadez include:
Vaginal bleeding. Increased vaginal discharge. Flushed red. Skin rash. Feeling tired. Swollen hands or feet. Common side effects of Rolnadez include:
Severe allergic symptoms such as sudden difficulty breathing, hives, or hives-like rash, dizziness, swelling in the mouth, face or throat, Blood a mass in a small or large vessel. Sudden confusion. Weakness, loss of strength on one side of the body. Loss of language. Reduced red blood cells. Increased triglycerides. Dizzy. Headache . Tingling or pins-and-needles sensation in the hands and feet. Taste change. Diarrhea. Constipation. Hair loss. Pain from cancer. Cataract. Changes in liver enzyme levels. Steatosis. Leg cramps. Muscle pain. Itching genitals Uterine fibroids. The uterine lining thickens. Less common side effects of Rolnadez include:
Endometrial cancer. Leukopenia. Myelitis. Pneumonia A blood disorder that causes bruising or bleeding more easily, or unexplained bleeding. Cirrhosis. Increased blood calcium levels. Rare side effects of Rolnadez include:
Stevens-Johnson syndrome. Uterine cancer. Swelling of the optic nerve at the back of the eye can lead to progressive blurred vision. Damage to the optic nerve. Liver disorders such as cholestasis, hepatitis or liver failure. Short-term decrease in platelet count. Changes in the cornea. Irregular menstrual cycle. Ovarian inflammation. Endometrial optimism . Vaginal polyps. Inflammation of the small blood vessels can lead to cyanosis. Cancer gets worse or flares up. Very rare side effects of Rolnadez include:
Lupus erythematosus of the skin. Venous thromboembolism. Transient thrombocytopenia. If you see any unusual symptoms while using Rolnadez, you should immediately notify your doctor or go to a medical facility for timely treatment.

Rolnadez may interact with the following drugs: Rolnadez may interact with the following drugs:
Paroxetin. Fluoxetine. Bupropion. Quinidine. Cinacalcet. Anticoagulants such as warfarin. Cytotoxic drugs (used in cancer treatment). Rifampicin . Aromatase inhibitors. Bromocriptine. Allopurinol. Aminoglutethimide. Letrozole. Estrogen-type drugs. To make sure it is safe to take Rolnadez, you need to tell your doctor about all the medicines you are taking, including prescription and over-the-counter medicines.