Uses of Simavas 10

Simavas 10 is used in combination with a cholesterol- and fat-reducing diet as prescribed by a doctor to effectively treat conditions such as: primary hypercholesterolemia, coronary events or atherosclerosis. . During treatment with Simavas 10, patients need to make sure to follow the doctor's instructions to soon reverse the disease.

Simavas 10 is a prescription drug, often combined with a cholesterol- and fat-restricted diet to help patients reduce total cholesterol and bad LDL cholesterol. Currently, Simavas drug is available in the form of film-coated tablets, each box includes 2 blisters x 15 tablets or 3 blisters x 10 tablets.
Simavas drug is distributed on the market with 2 main forms, including Simavas 10 and Simavas 20. Each Simavas tablet contains the following pharmaceutical ingredients:
Main active ingredient: Simvastatin 10mg or 20mg.
Other excipients just enough: Pregelatinized starch, Butylated Hydroxyanisole, Microcrystalline cellulose, Citric Acid, Sodium lauryl sulphate, Magnesium stearate, Ascorbic Acid, Povidon, Polymethacrylate, Talc, Colloidal Silicon Dioxide, Titanium dioxide, Triethyl citrate, Hypromellose, Polyethylene glycol , red iron oxide and yellow iron oxide.

2.1 Uses of the drug Simavas 10 Simvastatin active ingredient in the drug Simavas belongs to the group of cholesterol-lowering drugs, acting as a specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Simvastatin has the ability to lower normal and even elevated levels of LDL cholesterol in the blood. This effect of Simvastatin is due to the mechanism of lowering VLDL cholesterol levels as well as the induction of LDL receptors, leading to decreased production or increased catabolism of LDL cholesterol.
Currently, the active ingredient Simvastatin is commonly recommended by doctors as a dietary supplement for patients with primary hypercholesterolemia caused by increased levels of bad LDL cholesterol. Especially in people at risk for coronary artery disease unresponsive to current diets. In addition, Simvastatin is also used to reduce LDL cholesterol in patients with elevated both cholesterol and triglyceride levels in the blood.
2.2 Indications for use of Simavas 10 drug Simavas 10 is usually prescribed by doctors for the following cases:
Combination treatment with a cholesterol- and fat-reducing diet to reduce total cholesterol and bad cholesterol levels. LDL for patients with primary hypercholesterolemia type IIa and IIb. Primary primary prevention of coronary events for individuals with hypercholesterolemia without specific clinical symptoms of coronary artery disease. This reduces the risk of heart attack and death from cardiovascular disease. The treatment of atherosclerosis in patients with hypercholesterolemia with clinical signs associated with coronary artery disease, including previous myocardial infarction, helps to slow progression of coronary heart disease and reduce the risk of coronary heart disease. significant acute coronary events. 2.3 Contraindications to using Simavas 10 Do not arbitrarily use Simavas 10 for the following cases without a doctor's prescription:
Patients with hypersensitivity or allergy to HMG-CoA reductase inhibitors. Patients with progressive liver disease or persistent elevations of serum transaminases for unknown reasons. Pregnant women and nursing mothers.

Below is the dose of Simavas 10 according to the general recommendations of the doctor for each patient group:
Simavas dose for adults:
Take the starting dose of 5 - 10mg / time / day in the evening. A dose adjustment may be considered for the patient every 4 weeks of treatment. Use a maintenance dose of 5-40mg/day in the evening. Simavas dose for children:
Currently, the safety and effectiveness of Simavas 10 for children have not been specifically verified, so it should not be used in this person without the approval of a doctor.
Combination therapy:
Using Simavas 10 with Diltiazem, Dronedarone and Verapamil: Use Simavas not more than 10mg/day, Simavas 10 with Amlodipine, Ranolazin and Amiodarone: Use Simavas not more than 20mg/day.

Simavas 10 is in the form of tablets, so patients need to take it orally. Before treatment with Simavas 10, it is necessary to adopt a standard cholesterol-lowering diet, then continue the diet throughout the course of medication.
There have been a few cases of overdose with Simavas 10, but most of them are asymptomatic and most of the patients are able to recover without experiencing any serious sequelae. In the event of symptoms of an overdose of Simavas 10, the patient should immediately notify the doctor for treatment of the symptoms and the application of measures to support the general condition to help the body recover quickly.

During treatment with Simavas 10, patients may inadvertently experience some of the following side effects:
Constipation, heartburn or diarrhea. Stomach pain . Headache. Dizzy. Nausea or vomiting. Allergy. Myositis or muscle pain. Increased blood sugar. Globulinuria status. If any of the above mentioned side effects appear after taking Simavas 10, the patient should immediately contact the treating physician for advice and appropriate management.

Simavas 10 should be avoided at the same time with the following drugs to avoid the risk of an interaction reaction, including:
CYP3A4 enzyme inhibitors taken with Simavas 10 may increase the concentration of the active substance. Simvastatin in plasma, thereby leading to a high risk of myopathy or myopathy. The anticoagulant Indandione when taken with Simavas 10 may increase prothrombin time or bleeding time. Therefore, it is necessary to monitor the prothrombin time in patients receiving anticoagulants. Digoxin when co-administered with Simavas 10 may slightly increase the serum concentration of Digoxin. Using Simavas 10 in combination with other fibrinolytic drugs, gemfibrozil, high doses of Niacin (over 1g/day) or colchicine may increase the risk of muscle damage. Concomitant administration of Simavas 10 with hepatitis C and HIV protease inhibitors may result in conditions such as muscle damage, rhabdomyolysis, kidney failure, or death. Above is the important information about the drug Simavas 10, patients need to read the instructions carefully before using. If there are any other problems, you should contact your doctor for in-depth advice.