Uses of Sizoca-5

Sizoca-5 medicine has the main active ingredient is Olanzapine with a strength of 5mg and other excipients in a sufficient amount. This is a psychotropic drug used to treat psychosis, treat schizophrenia.

Sizoca-5 drug has the active ingredient Olanzapine with and other excipients in sufficient quantities. This is a psychotropic drug used to treat psychosis, treat schizophrenia.
Sizoca-5 drug is prepared in the form of film-coated tablets, suitable for direct oral use. The packaging is a box of Sizoca-5 with 3 blisters, each blister contains 10 pills.
1.1. Pharmacokinetics of active ingredient Olanzapine: Active ingredient Olanzapine is an antipsychotic with broad pharmacological activity on several receptor systems.
1.2. Pharmacokinetics of the active substance Olanzapine Absorption: The active substance Olanzapine is well absorbed following the direct oral route. The drug reaches peak plasma concentrations within 5 to 8 hours. Food does not affect absorption. The absolute oral bioavailability of Olanzapine compared with intravenous administration has not been determined. Olanzapine plasma concentrations were linear and dose-proportional in clinical trials with doses ranging from 1 to 20 mg. Distribution: Active ingredient Olanzapine binds mainly to Albumin and a1-acid-glycoprotein. Metabolism: Olanzapine is metabolised in the liver by conjugation and oxidation. Elimination: Following oral administration, the mean half-life in healthy subjects varies with age and sex. 1.3. The action of the active ingredient Olanzapine The main active ingredient of the drug is Olanzapine, which belongs to the group of antipsychotics. The mechanism of action of the main active ingredient Olanzapine is due to the selective effect on certain neurons such as Dopamine and Serotonin (5 HT2A) without causing much effect on the motor function of the patient, from It has antipsychotic effects. In addition, this active ingredient also has antagonistic effects on Muscarinic receptors and H1 receptors of Histamine. This effect is related to undesirable effects including the possibility of somnolence or the risk of hypotension in the standing position.

Sizoca-5 drug is indicated for use in the treatment of:
Treatment of schizophrenia or treatment of other psychotic disorders with specific manifestations that have responded to the first treatment. Treatment of bipolar disorder: manic or mixed exacerbations, rapid cycling bipolar disease, acute agitation in schizophrenia or bipolar disorder.

3.1. Dosage of Sizoca-5 The dose of Sizoca-5 drug is prescribed by the treating doctor or refer to the specific treatment dose below:
Initial dose: take 1-2 tablets/day. In case of liver failure and kidney failure, the starting dose is 1 tablet per day. Maintenance dose: 2 tablets/day. Depending on the response of each specific user to adjust the dose, the dose is from 1 to 4 tablets / day and used at 1 week intervals. Doses of more than 2 tablets should be closely monitored before prescribing. 3.2. How to use Sizoca-5 effectively Sizoca-5 medicine is made in the form of film-coated tablets, so you need to use it orally. Take Sizoca-5 with an adequate amount of water. Do not crush, chew or break the tablet. You should take Sizoca-5 at the same time of day to achieve the best treatment effect and limit forgetting.

During the use of Sizoca-5 drug, patients may experience some of the following side effects:
Some unwanted effects may be encountered during the use of Sizoca-5 such as: hypersensitivity reactions , weight gain, peripheral edema, allergies, urticaria, boils, gastrointestinal disturbances, orthostatic hypotension, somnolence, dizziness, vertigo, extrapyramidalism, dry mouth, nausea, vomiting, .... Sometimes, Sizoca-5 users may experience cases of increased liver enzymes, eosinophils, ... When experiencing any abnormal symptoms during the use of Sizoca-5 drug. , you need to actively notify the treating doctor immediately for timely support, should not be subjective but ignore the signs and symptoms.

In the process of using Sizoca-5 drug concurrently with other drugs that can cause drug interactions:
Carbamazepine used together with Sizoca-5 drug reduces the bioavailability of the drug, the clearance of the drug increases by 40% and reduce the half-life by 20%. Central nervous system depressants cause a synergistic effect with the main active ingredient Olanzapine, which in turn may cause undesirable signs and symptoms, namely dizziness, lightheadedness, somnolence. The above symptoms also occur when used concurrently with alcohol-containing preparations such as alcohol. Activated charcoal can interfere with the absorption of Sizoca-5, reducing the AUC concentration by 50 - 60%. Note that the patient should not smoke during treatment with Sizoca-5. The reason is that the use of tobacco can increase the cumulative toxicity of the drug and increase the toxicity to the body. CYP1A2 inducers or inhibitors may affect the absorption and metabolism of Sizoca-5. Therefore, to ensure safety, before using Sizoca-5, you should actively list the drugs, functional foods as well as medical history for the treating doctor to know for advice on drug use. to be safe and effective.

6.1. Contraindications of the drug Sizoca-5 Contraindicated to use Sizoca-5 drug for people with hypersensitivity or sensitivity to any of the ingredients of the drug. Do not use Sizoca-5 for people with narrow-angle glaucoma. Sizoca-5 is not recommended for use by people under 18 years of age. Patients with dementia related to psychosis should not use Sizoca-5. 6.2. Note and caution when using Sizoca-5 drug During treatment with Sizoca-5 drug, you should not use it with alcohol, beer, stimulants because it can affect the effect of the drug. Sizoca-5 should be used with caution in people with a history of exacerbations of asthma. Use caution when treating people with liver or kidney disease. Monitor liver and kidney function in people with a family history of these diseases before giving the drug. Monitor blood sugar while using Sizoca-5, because the drug can affect blood sugar. Using Sizoca-5 can make you feel drowsy and tired. Therefore, caution should be exercised for those who often drive and operate machinery and equipment. Sizoca-5 is a prescription drug, used only when prescribed by the treating doctor. Patients do not arbitrarily buy drugs or change the dose without the consent of the treating doctor. 6.3. Note to use the drug with other people Pregnant women: There have not been enough studies to prove the safety of Sizoca-5 drug for these people. Therefore, pregnant women need to consult their medical doctor and consider carefully before using. Lactation: Some reports have shown that Olanzapine is excreted in breast milk, therefore breastfeeding should be discontinued if treatment is imperative. People who drive and operate machines: Sizoca-5 medicine may increase dizziness, somnolence, thereby affecting the ability to drive and use machines. During the use of Sizoca-5, you need to be careful when conducting activities that require alertness and concentration. 6.4. Store Sizoca-5 medicine Store Sizoca-5 medicine at room temperature, from 20 - 30 degrees C. Avoid storing Sizoca-5 in places with direct sunlight or high humidity. Keep Sizoca-5 out of reach of children or household pets. Above is all information about Sizoca-5 drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy Sizoca-5 to treat the disease at home, because there may be unwanted side effects on health.
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