Uses of the drug Losium 50

Losium 50 belongs to the line of prescription drugs with the effect of lowering blood pressure. The drug has the main ingredient Losartan Potassium in the form of film-coated tablets. Made in Cadila Pharm., Ltd - INDIA. Let's learn more about the Losium 50 drug line through the following article.

The active ingredient Losartan has antihypertensive effect due to its antagonistic action with Angiotensin II. Lorsartan helps vasoconstriction and aldosterone secretion by selectively inhibiting Angiotensin II.
Losium 50 is well absorbed and first metabolized by the liver, bioavailability is only about 33%. Losium 50 is indicated for use in the treatment of mild to moderate hypertension and alone or in combination with other antihypertensive agents.

Losium 50 is used as prescribed by a doctor or pharmacist. The drug is for oral use and the patient should take the tablet whole (do not chew, crush, or crush) to avoid reducing the effect of the drug.
Depending on the condition of each person, there will be the most appropriate dose adjustment.
Initial dose: take 1 tablet / day Maintenance dose: use from 25 - 50 mg Losartan, 1 time a day. If necessary increase to 100 mg Losartan once daily. Elderly, renal insufficiency or reduced endothelial fluid: starting dose of Losartan 25mg, once a day. In case of overdose:
Symptoms: The patient may experience a drop in blood pressure and tachycardia or may experience bradycardia when overdosed. Treatment: Patients should immediately go to the nearest medical facility for examination and the most appropriate treatment measures. Hemodialysis is not effective in overdose of Losium 50.

Do not use Losium 50 in the following cases:
Patients with hypersensitivity or allergy to Lorsartan or any of its ingredients. Pregnant and lactating women. Children < 18 years old

Losium 50 when used in combination with some of the following drugs may cause drug interactions such as:
Barbiturates. Addictive sleeping pills. Rifampin drug. K-sparing diuretics Salt substitutes K Supplements K NSAIDs . Alcohol, ACTH, Corticosteroids, Muscle relaxants, Quinidine, Lithium. Anticoagulants Medicines for Gout. Anesthesia, vitamin D, Glycoside. Cholestyramine resin. Cimetidine may cause an increase in the area under the losartan curve of about 18%. Phenobarbital reduces the AUC for losartan by approximately 20%. To be safe, patients should inform their doctor or pharmacist about all the drugs, including supplements, they are taking to be considered for medication to avoid possible interactions.

During the use of Losium 50, patients may experience some unwanted side effects such as:
Orthostatic hypotension, hypotension, chest pain, Grade II A-V block, tachycardia , sinus bradycardia, facial edema, flushing. Insomnia, anxiety, dizziness, lightheadedness, ataxia, depression, confusion, migraine, headache, sleep disturbance, fever. Increased or decreased blood K. Gout. Diarrhea, constipation, loss of appetite, indigestion, flatulence, nausea/vomiting, loss of taste, gastritis, intestinal spasms. Lower hemoglobin and hematocrit. Leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia. Back pain, muscle pain, leg pain, bone pain, tremor, paresthesia, muscle weakness, joint edema, fibromyalgia. Hyperuricemia or hypouricemia, urinary tract infection, slight increase in creatinine or urea. Cough, shortness of breath, nasal congestion, sinusitis, bronchitis, nosebleeds, rhinitis, airway congestion, throat discomfort. Alopecia, erythema, dermatitis, dry skin, itching, photosensitivity, urticaria, bruises, rash. Impotence, renal failure, decreased libido, polyuria, nocturia, interstitial nephritis. Hepatitis, increased liver function, intrahepatic cholestatic jaundice, pancreatitis. Blurred vision, decreased vision, conjunctivitis, burning, eye pain. Tinnitus. Sweating. Hyperglycemia Increased blood lipids. Hypomagnesaemia and hyponatremia, hypophosphataemia, hypercalcemia, hypochloremic alkalosis. If there is an abnormality, the patient should immediately contact the doctor for advice and timely help.

Patients should carefully consult some of the following notes before taking Losium 50:
Using Losartan in pregnant women over 3 months has the risk of causing anuria, hypotension, oliguria, less amniotic fluid, deformity. craniofacial and infant mortality. Absolutely do not use Losartan while pregnant, if you find out that you are pregnant while using the drug, you should stop Losartan as soon as possible. There are no data to show whether Losartan is excreted in human milk. Therefore, losartan should be discontinued during breast-feeding due to the risk of harm in the nursing infant. Losartan can cause lightheadedness and dizziness when used. Do not drive or operate machinery when these side effects appear. It is necessary to carefully monitor the following subjects: dehydrated, treated with diuretics, at risk of hypotension, people with one kidney left, with renal artery stenosis. In these cases, the dose may be reduced. A dose reduction may be necessary in these cases. Patients with liver failure must take a lower dose of Losartan. Carefully read the information on the use of Losium 50 in the leaflet before use. Losium 50 belongs to the line of prescription drugs with the effect of lowering blood pressure. The drug has the main ingredient Losartan Potassium in the form of film-coated tablets. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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