Uses of Tipaprim

Tiphaprim is an antibiotic indicated in cases of infections caused by susceptible bacteria. Let's learn about the uses and notes when using Tiphaprim through the article below.

The drug Tiphaprim contains the active ingredients Sulfamethoxazole and Trimethoprim, which are manufactured in tablet form under two strengths of Tiphaprim 480 and Tipaprim 960.
Active ingredient Sulfamethoxazole is a broad-spectrum antibiotic that is active against many gram-positive and gram-negative aerobic bacteria including Streptococcus, Staphylococcus, Neisseria Gonorrhoeae, E.coli, Enterobacter, Proteus indol positive, Klebsiella, Haemophilus Influenzae... Bacterial strains resistant to Sulfamethoxazole include Campylobacter, Enterococcus, anaerobic bacteria... Mechanism of action of the drug is competition with para aminobenzoic acid (PABA) thanks to its high affinity for Dihydropteroate Synthetase (inhibiting the phase of bacterial synthesis of folic acid).
Active ingredient Trimethoprim has a bactericidal or bacteriostatic effect depending on the growth conditions of the bacteria. The drug acts by inhibiting the enzyme dihydrofolate - reductase, thereby inhibiting the conversion of bacterial dihydrofolic into tetrahydrofolic acid - a compound necessary for the biosynthesis of Purin, amino acids, thymidine, essential DNA.
Tiphaprim is indicated in the following cases:
Urinary tract infections; Infections caused by bacteria sensitive to Trimethoprim and Sulfamethoxazole; Respiratory tract infections; Chronic bronchitis exacerbation; Gastrointestinal infections. The use of Tiphaprim is contraindicated in the following cases:
Patients with hypersensitivity to Sulfamethoxazole, Trimethoprim or any component of the drug; Patients with liver parenchymal damage; Patients with severe renal failure; Pregnant women.

The dose of Tipaprim is prescribed by the treating doctor based on the patient's condition. Some recommendations on dosage in adults are as follows:
Treatment of urinary tract infections: Take 1-2 tablets of Tiphaprim 480 each time, 2 times a day. 10 days of treatment; Treatment of respiratory infections: Take 1-2 tablets of Tipaprim 480 each time, 2-3 times a day. 10 days of treatment; Treatment of gastrointestinal infections caused by bacillus dysentery: Take 1-2 tablets of Tiphaprim 480 each time, 2 times a day. 5 days of treatment.

Tipaprim may cause some unwanted effects as follows:
Digestive disorders; Stomatitis, skin reactions, tinnitus; Erythema multiforme; Stevens - Johnson syndrome ; Lyell's syndrome; Decrease in neutrophils; Decreased platelets. Patients should inform their doctor if they experience unwanted effects while taking Tipaprim.

Before being treated with Tiphaprim, the patient should inform the doctor about the history of allergy to the treatment drugs, the history of liver disease, kidney disease and blood disorders (anemia, Porphyrin metabolism disorders). , bronchial asthma, bone marrow dysfunction, metabolic disorders.
Tiphaprim may cause live bacterial vaccines not to work, so do not receive the vaccine during treatment with the drug.
Tiphaprim can increase sensitivity to sunlight, so while taking the drug, patients should limit sun exposure. Wear protective clothing and apply sunscreen when outdoors.

Tipaprim may interact with some drugs such as Methotrexate, Dofetilide, Warfarin, Methenamine...
Drug interactions occur increasing the risk of having effects and reducing the therapeutic effects of Tiphaprim, so to be sure Safe and effective in treatment, patients need to inform their doctor about the drugs and food they are using before taking Tiphaprim.