What does Mexold 500 do?

What is the effect of the drug Mexold 500? Mexold 500mg is a drug belonging to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs. Medicines for the treatment of gout and joint diseases. The following article summarizes useful information to know more about what mexold 500 does and how to use it effectively.

Mexold drug's main ingredient is acetaminophen (paracetamol) 500mg, is prepared in many different forms of capsules, tablets, powder or soluble granules. Acetaminophen is used to relieve pain and reduce fever. Acetaminophen is used to treat mild to moderate pain, to treat moderate to severe pain associated with opioids, or to reduce fever. Conditions including headache, muscle pain, arthritis, backache, toothache, sore throat, cold, flu, and fever are common conditions where acetaminophen is used.
Acetaminophen is usually taken orally, but can also be given intravenously.
Orally, Paracetamol is absorbed directly from the gastrointestinal tract very quickly after oral administration. Paracetamol is rapidly and evenly distributed in many body tissues. About 25% of Paracetamol in the blood is bound to plasma proteins. The half-life is about 2 hours. The liver metabolizes the drug and is excreted in the urine, mostly as conjugates with glucuronic acid. Pharmacodynamics Paracetamol is the active metabolite of phenacetin. Paracetamol has an effective analgesic and antipyretic effect that can replace aspirin. However, it is not effective in treating inflammation. Drugs acting on the hypothalamus cause hypothermia, increased heat loss due to vasodilation and increased peripheral blood flow.
Paracetamol with therapeutic doses has little impact on cardiovascular and respiratory systems, does not change acid-base balance, does not cause irritation, scratches or stomach bleeding like salicylate because paracetamol does not affect systemic cyclooxygenase but Only affects cyclooxygenase/prostaglandin of the central nervous system. Pharmacokinetics Absorption: Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 30-60 minutes after oral administration of a therapeutic dose.
Distribution: Paracetamol is rapidly and evenly distributed in most body tissues. Approximately 26% of paracetamol in the blood is bound to plasma proteins.
Metabolism: Paracetamol is n - hydroxylated by cytochrome P450 to form n - acetyl - benzoquinonimine, a highly reactive intermediate. This metabolite reacts with the sulfhydryl (thiol) groups in glutathione and is inactivated. However, when high doses of paracetamol are taken, this metabolite is formed in sufficient quantities to deplete hepatic glutathione, in which condition its reaction with the sulfhydryl group of liver proteins is increased, which can lead to necrosis. liver death.

The drug mexcol 500 is indicated in cases of pain relief: headache, fever, toothache, muscle pain, menstrual pain, pain due to bone and joint diseases.
Phenacetin is the main active ingredient of acetaminophen. Paracetamol's analgesic and antipyretic effects can replace aspirin, but its effectiveness in treating inflammation is less. The drug acts on the hypothalamus - the temperature control area of ​​the body to cause hypothermia, vasodilation and increased peripheral blood flow, thereby increasing heat output.
Treatment with paracetamol has little effect on the cardiovascular and respiratory systems, does not change the intravascular acid-base balance, does not cause irritation, scratch or gastric bleeding like salicylate because paracetamol does not affect the whole cyclooxygenase only affects the cyclooxygenase/prostaglandin of the central nervous system. However, Paracetamol does not lower body temperature in people with normal body temperature. In addition, when overdose Paracetamol will produce a metabolite is n - acetyl - benzoquinonimine, the liver will not be able to eliminate it in time and cause severe toxicity to the liver.

3.1. How to take it – Acetaminophen dosage comes in different forms such as capsules, liquid tablets, chewable or disintegrating, and soluble powders or granules. Read and follow the instructions for use carefully. Ask your doctor or pharmacist if you need help.
Adults and adolescents at least 12 years old: 500 -1000 mg/time, about 4-6 hours apart. The maximum dose in 1 use is 1000 milligrams (mg) and the maximum is 4000 mg (4g) in 24 hours. Children under 12 years old: 250-500mg/time, 4-6 hours apart. Do not take more than 500mg of infant formula acetaminophen in 24 hours. Do not give too strong acetaminophen to children under 12 years of age without a prescription from a doctor.
Dosage for children is based on age and weight. Carefully follow the dosage instructions provided with acetaminophen. If you intend to use this medicine for children under 2 years old, you need to consult a specialist or have a doctor's prescription.
Acetaminophen made for infants comes with its own dropper or oral syringe. If the drug is used in the neonate, the dose should be carefully measured because the liver function of the neonate is still incomplete and measurement with an inappropriate device can cause an overdose. Use only the dosing device provided to measure infant dosing.
Acetaminophen made for infants is available in two different dosage concentrations and each comes with its own dropper or oral syringe. These dosing devices are not equal between different concentrations. Using the wrong device can cause you to give the wrong dose of infant acetaminophen. Do not mix and match dosing devices between different infant acetaminophen formulations. Shake the dropper can be applied before each use, but be sure to follow the instructions on the package of the medicine listed on the package.
Acetaminophen is also available in chewable tablet form, in which case you must chew it thoroughly before you swallow it. Make sure your hands are dry when handling acetaminophen disintegrating tablets. Place the pill on your tongue. It will begin to dissolve immediately. Do not swallow the tablet whole. Let the medicine dissolve in your mouth without chewing.
To use acetaminophen effervescent granules, dissolve one sachet of effervescent granules in at least 120ml of water. Stir the mixture well so that the medicine is completely dissolved in the water and drink the entire glass of water immediately. To make sure you've finished the dose, rinse the cup by adding some water to the glass you just took the pill, shake it gently, and continue drinking the entire glass of water.
Stop using and contact the nearest medical facility or your treating doctor if you experience the following:
After 2 days of use, still have symptoms of sore throat; After 3 days of use, the fever continues; If you still feel pain after 7 days of use (or 5 days in the case of children); you experience unwanted side effects such as skin rash, persistent headache, nausea, vomiting, redness or swelling; Your symptoms don't get better, they get worse or if you have new problems. What to do if you miss 1 dose?
If you forget a dose, take it again as soon as you remember if it is not near the time for the next dose, if it is almost time for the next dose according to the previous dosing schedule, skip the missed dose and take the next dose. next. Do not automatically increase the dose at the next dose if the previous dose has been skipped.
What to do if overdose?
Some symptoms if you overdose: loss of appetite, nausea, vomiting, stomach pain, sweating and confusion or weakness. After the above symptoms, you may also feel pain in your upper abdomen, dark urine, and yellowing of your skin or eyes.
Go to the nearest medical facility immediately if you experience symptoms of an overdose.
3.2. If you are taking any other cold, allergy, pain reliever or sleeping pills you need to list them all with your doctor or pharmacist and get advice on how to use them. Acetaminophen is an ingredient that can be found in many combination medications. When more than one drug is used in combination, the amount of acetaminophen absorbed into the body may be more than the prescribed dose, leading to an overdose that can cause unwanted effects and even death. Check the label of your medicine when you are taking more than one medicine to see if it contains acetaminophen.
Avoid drinking alcohol, beer, or alcoholic beverages while using acetaminophen because alcoholic beverages can increase the risk of liver damage while using acetaminophen.
Avoid using other medicines that contain acetaminophen, as this will increase the dose from the required dose.
Avoid using stimulants.
Mexold 500 is contraindicated for people who are sensitive to Acetaminophen, people with frequent anemia, people with heart disease, lung disease, liver failure, kidney failure, people with hereditary glucose - 6 - phosphate dehydrogenase deficiency.
3.3. Side effects of mexold Tell your doctor if you have signs of an allergic reaction to acetaminophen such as hives; shortness of breath; swelling of the face, lips, tongue, or throat.
In rare cases, acetaminophen can cause a serious skin reaction. can even cause death. This can happen even if you have had no reaction to the drugs when using them before. If you experience skin redness or a rash that shows signs of spreading, blistering, and peeling, stop using the medicine immediately and contact your treating physician immediately for an evaluation.
Here are some liver problems that need to be monitored when using the drug, which should be stopped immediately if you experience symptoms such as:
Yellow skin or eyes Dark urine or clay-colored stools Fatigue, itching Eat loss Eat well and watch out for stomach upset (upper right) Common side effects of acetaminophen use are usually less severe and you may not experience any side effects. The above is also not a complete list of side effects and other side effects that may occur when using this medicine. Please contact your treating doctor immediately for guidance, assessment and treatment of side effects when encountered.