What is Sintrom 4mg?

Sintrom 4mg is an anticoagulant, used mainly for the prevention and treatment of thromboembolic complications caused by myocardial infarction, mitral valve disease, atrial fibrillation or deep vein thrombosis,... In the process of using the drug, the patient must adhere to the correct dosage and method of use as instructed by the doctor to achieve the best effect.

Sintrom 4mg is an anticoagulant, antiplatelet and fibrinolytic drug. The drug is researched and manufactured in the form of tablets, manufactured by Novartis Farma S.P.A - Italy. The main ingredient of Sintrom 4 is Acenocoumarol (4 mg content), packaged in a box of 3 blisters x 10 tablets.

2.1. Indications for use of Sintrom 4mg Sintrom 4mg is mainly indicated for the following cases:
Prophylaxis of thromboembolic complications due to myocardial infarction, such as severe left ventricular dysfunction, Cardiac thrombus or embolic left ventricular dysrhythmias during continued treatment as an alternative to heparin. In addition, Sintrom 4mg is also used to prevent recurrent myocardial infarction in patients who cannot take aspirin. Used to prevent thromboembolic complications caused by prosthetic valve disease, mitral valve disease or atrial fibrillation. Treatment of pulmonary embolism, deep vein thrombosis and prevention of recurrence when continuing to replace Heparin. Prophylaxis of pulmonary embolism or venous thrombosis in hip surgery. Prophylaxis of intracatheter thrombosis. 2.2. Uses of the drug Sintrom 4mg serb Pharmacology and main mechanism of action of the ingredient Acenocoumarol:
Acenocoumarol (4mg content) has anticoagulant effect, helping to prevent and treat conditions with thrombosis in blood vessels. . The nature of Acenocoumarol is a vitamin K antagonist, which plays a role in interfering with the mechanism of vitamin K reduction in the liver and synthesizing 4 clotting factors (including II, VII, IX and X). Acenocoumarol's indirect anticoagulant effects work by blocking the synthesis of many clotting factors. After oral administration, Aacenocoumarol will lower blood prothrombin within 36-72 hours. After stopping the drug, the anticoagulant effect may continue for up to 2-3 days. In addition, Acenocoumarol also inhibits the formation and growth of pre-existing blood clots. As a result, secondary thromboembolic symptoms are prevented even though the active ingredient is not capable of direct thrombolysis. Pharmacokinetics: Acenocoumarol is rapidly absorbed from the gastrointestinal tract and peak plasma concentrations are reached in 1-3 hours. The drug is strongly bound to plasma proteins, up to 97%, the free part is active and metabolized. In addition, Acenocoumarol is also absorbed through the placenta and in breast milk. The half-life of the drug will take place within 8-11 hours. Acenocoumarol will be eliminated mainly in the form of metabolites in the urine and a small part in the bile (faeces).

3.1. Dosage of Sintrom 4mg The dose of Sintrom 4 will be determined based on the results of the patient's blood clotting time through the IRN test. Therefore, the dose of the drug will be prescribed by the doctor depending on each different patient, specifically:
Children: The use of Sintrom 4mg for children is still limited, but if necessary When taking medication, the doctor will have to monitor the patient from the beginning to get the right dose of the drug. Adults: Take 4mg/day (the first 2 days of use), the next day need to check with your doctor to determine the next appropriate dose. Elderly: Use less and only 3/4 or 1/2 of the adult dose initially. 3.2. How to use Sintrom 4mg Sintrom 4mg is usually taken orally. Patients should take the drug with water.
In addition, the patient should also take Sintrom 4 exactly as directed by the doctor and use it at a fixed time of the day. The best time to take Sintrom 4mg is in the evening. During the use of the drug, patients need to monitor IRN to adjust the appropriate dose.

How to handle an overdose of Sintrom 4mg:
In case of taking an overdose of Sintrom 4mg, the patient may experience symptoms such as coughing or vomiting blood, bruising, abdominal pain, headache, bleeding. nose, black or red stools, etc. When any of the above symptoms appear, immediately take the patient to the nearest local medical facility for timely examination and treatment. How to handle when you miss a dose of sintrom 4mg:
If you forget to take a dose of sintrom 4mg within 8 hours, the patient can take up the dose as soon as possible. However, if this time is exceeded, the patient should skip the missed dose and use the next dose as usual. If you miss a dose, you should also remember it and notify your doctor for advice and support.

When taking Sintrom 4mg, patients may experience some of the following common to rare side effects:
Common side effects include itching, fever, rash, hair loss, nausea, diarrhea bleeding, individual joint pain. Rare side effects include unusual pain and swelling, nosebleeds, paralysis, sudden shortness of breath, dizziness, localized skin necrosis, vasculitis, liver damage, etc. Also, report it immediately. Tell your doctor if you have any of the following symptoms:
Bleeding gums . Bleeding from the cut site takes a long time to stop bleeding. Menstrual cycle lasts longer than usual. Numbness and tingling of the face, feet or hands. Pain, swelling, or discomfort in the muscles. Signs of a serious allergic reaction such as difficulty breathing, low blood pressure, hives, swelling of the face or throat. Bleeding in the eye, vomiting black fluid that looks like coffee grounds. Fainting.

Sintrom 4mg serb is contraindicated for use in the following cases:
People who are allergic or hypersensitive to Coumarin derivatives or ingredients in the drug. People at high risk of bleeding, recent ocular and neurological surgery or likely to need re-surgery. People with severe liver failure. People with cerebrovascular accident. Patients with severe acute renal failure (with creatinine clearance less than 20ml/min). Patients with advanced peptic ulcer disease. People with esophageal varices. People who are taking high-dose aspirin, systemic/vaginal miconazole, non-steroidal anti-inflammatory drugs containing Pyrazole, Chloramphenicol, Phenylbutazone or Diflunisal. Some drugs can interact with Sintrom 4mg, including:
Drugs that increase the concentration/effect of Sintrom: Antibiotics (Norfloxacin, Ofloxacin, Ciprofloxacin, Tetracycline, Trimethoprim); antiarrhythmic drugs (Amiodarone); Acetaminophen (cold medicine, paracetamol); other anticoagulants (Enoxaparin, Calciparine, or Heparin); antiplatelet drugs (Clopidogrel, Aspirin); antifungal drugs (Fluconazole, Ketoconazole); the antihypertensive drug Nicardipine; non-steroidal anti-inflammatory drugs (NSAIDS) (Piroxicam, Voltarel); diabetes medicine (Pioglitazone, Sulfonamide); the anti-dyslipidemic drug Gemfibrozil. Drugs that decrease the concentration/effect of Sintrom: Anticonvulsants (Carbamazepine); sleeping pills (Secobarbital, Phenobarbital); tuberculosis medicine (Rifampin); Aminoglutethimide. During the use of Sintrom 4mg, patients should note the following:
Do not drink alcohol while using Sintrom. Follow the correct dose and use of the medicine prescribed by your doctor. Do not go on a diet or change your diet too much to adjust your body weight while taking this medicine. According to experts, women who are pregnant should not use Sintrom 4mg, because this drug can directly affect the fetus, especially in the first and last trimesters of pregnancy. The use of Sintrom 4mg may lead to an increased risk of fetal malformations or miscarriage. Women who are breastfeeding should also not use Sintrom 4mg. In case of necessity, children can be supplemented with vitamin K. People with specific jobs that require high concentration such as operating machinery or driving vehicles should be cautious when using Sintrom. Avoid excessive activity or collision that may cause injury/bleeding. Store Sintrom at room temperature, away from direct sunlight and out of reach of children. In summary, Sintrom 4mg is an anticoagulant, used mainly for the prevention and treatment of thromboembolic complications caused by a number of cardiovascular diseases. Patients need to take the drug exactly as prescribed by the doctor to increase the effectiveness of treatment and ensure safety for health.