What is Thylmedi?

Thylmedi drug is made in the form of tablets, with the main ingredient being Methylprednisolone. The drug is indicated in the treatment of anti-inflammatory, immunosuppressive for some inflammatory and autoimmune diseases.

Thylmedi drug has the main ingredient Methylprednisolone 16mg. Methylprednisolone is a glucocorticoid with immunosuppressive, anti-allergic and anti-inflammatory effects.
Indications for use of Thylmedi:
Used in non-specific therapy requiring the anti-inflammatory, immunosuppressive effects of glucocorticoids such as: systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis, some forms of vasculitis positive and nodular periarteritis, bronchial asthma, hemolytic anemia, chronic ulcerative colitis, agranulocytosis, severe allergic diseases (including anaphylaxis); Treatment of primary nephrotic syndrome. Contraindications to using Thylmedi:
People who are sensitive or allergic to the ingredients and excipients of the drug; Patients with severe infections (except tuberculous meningitis and septic shock); Skin lesions caused by fungi, viruses or tuberculosis; Taking a live virus vaccine.

How to use: Take the whole Thylmedi tablet with water.
Dosage:
Treatment of acute asthma: Use a dose of 32 - 48mg / day for 5 days. After that, the patient received additional treatment with a lower dose for 1 week. After the acute attack, reduce the dose gradually; Severe rheumatic diseases: Initially use Methylprednisolone at a dose of 0.8mg/kg/day, divided into several small doses. Thereafter, consolidation treatment is achieved with a single daily dose. Next, gradually reduce to the minimum effective dose; Rheumatoid Arthritis: Start with 4mg/day. In the acute episode, use a higher dose of 16-32mg/day, then reduce the dose gradually and quickly; Chronic ulcerative colitis severe acute exacerbation: Use dose 8-24mg/day; Primary nephrotic syndrome: Start with a dose of 0.8 - 1.6mg/kg for 6 weeks. Then, gradually reduce the dose over 6-8 weeks of treatment; Immune hemolytic anemia: Use dose 64mg/day for 3 days, then gradually reduce dose in 6-8 weeks of treatment; Sarcoid disease: Use a dose of 0.8mg/kg/day to relieve the disease. After that, the patient took a maintenance dose of 8mg/day. *Note with the dose of Thylmedi:
It is necessary to determine the dose of the drug according to each patient. In acute indications, glucocorticoids should be used at the lowest dose for the shortest duration of clinical effect; Using a single dose a day will cause fewer side effects than divided doses. When using large doses of drugs for a long time, it is recommended to apply therapy every other day, using a single dose every 2 days in the morning; It is recommended to monitor and periodically evaluate the parameters of hematopoiesis, osteoporosis, glucose tolerance, eye effects and blood pressure of the patient; When taking high doses of Thylmedi, it is recommended to prevent gastric and duodenal ulcers with histamine H2-receptor antagonists; During long-term treatment with glucocorticoids, patients should be supplemented with calcium to prevent osteoporosis. Overdose: When using Thylmedi long-term, patients may have Cushing's syndrome, osteoporosis, muscle weakness,... If the drug is used in too high a dose for a long time, it can cause adrenal suppression and increase adrenocortical function. The treatment is to reduce the dose gradually rather than stopping abruptly. Patients should consult their doctor for appropriate treatment.
Missed dose: If you forget to take a dose of Thylmedi, you should take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time, no need to double the dose.

When using Thylmedi (especially when taking high doses and long-term), patients may experience some unwanted side effects such as:
Common: Increased appetite, indigestion, loss of appetite. sleep, nervous excitability, diabetes, joint pain, hirsutism, nosebleeds, cataracts, glaucoma; Uncommon: Convulsions, psychosis, dizziness, headache, brain pseudotumor, delirium, hallucinations, mood swings, euphoria, edema, acne, hypertension, skin atrophy, Cushing's syndrome , glucose intolerance, pituitary-adrenal suppression, hypokalemia, alkalosis, amenorrhea, hyperglycemia, sodium and water retention, nausea, vomiting, peptic ulcer, abdominal distention, pancreatitis, inflammation Esophageal ulcers, osteoporosis, muscle weakness, bone fractures, hypersensitivity reactions,... When experiencing side effects of Thylmedi, patients should stop taking the drug and immediately notify their doctor or go to the nearest hospital. to be examined and dealt with in a timely manner.

Some notes patients need to remember before and while taking Thylmedi include:
Caution when using Thylmedi in people with osteoporosis, mental disorders, heart failure, stomach ulcers, duodenal ulcers, new connections blood vessels, hypertension, diabetes, growing children, pregnant women, the elderly; The risk of acute adrenal insufficiency may occur if the drug is stopped suddenly after a long period of treatment with Thylmedi or under stress; When using Thylmedi in high doses, it may affect the effectiveness of vaccination; Do not use drugs to drive or operate machinery; Thylmedi is not recommended for use in children. If it is necessary to use, parents need to let the child use the drug according to the doctor's prescription; Long-term systemic administration of Thylmedi to a pregnant mother may slightly reduce the birth weight of the newborn. Therefore, caution should be exercised when this drug is used in pregnant women; Breast-feeding: There are no contraindications to taking Thylmedi, but caution should be exercised and consulted with your doctor.

Drug interactions can affect the effectiveness of medications you are taking or increase side effects. To avoid drug interactions, patients should inform their doctor about the medications they are taking. At the same time, patients should not arbitrarily take the drug, stop or change the dose of the drug without the consent of the doctor.
Some drug interactions of Thylmedi include:
Methylprednisolone (the main ingredient of the drug Thylmedi) is an inducer of cytochrome P450 enzyme, a substrate of the enzyme P450 3A. Therefore, this drug affects the metabolism of drugs such as phenobarbital, phenytoin, carbamazepine, cyclosporine, erythromycin, ketoconazole, rifampicin; Phenobarbital, rifampicin, phenytoin and hypokalemic diuretics may decrease the effectiveness of methylprednisolone; Avoid concomitant use of Methylprednisolone with non-steroidal anti-inflammatory drugs because of the risk of gastric ulcer; Methylprednisolone can cause hyperglycemia, so people with diabetes need to take higher doses of insulin. During the use of Thylmedi, patients most need to comply with all the instructions of the doctor to ensure comprehensive therapeutic effects and avoid unpredictable side effects.
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